ID   NCI-N417
AC   CVCL_1602
SY   NCI-N-417; NCI N417; N-417; N417; NCIN417; NCI417N; NCI-H417; H-417; H417; NCI-N417D; N417D; N417d
DR   BTO; BTO:0003028
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ATCC; CRL-5809
DR   BioSample; SAMN03471029
DR   cancercelllines; CVCL_1602
DR   ChEMBL-Cells; CHEMBL3307265
DR   ChEMBL-Targets; CHEMBL613287
DR   ChEMBL-Targets; CHEMBL613517
DR   Cosmic; 688033
DR   Cosmic; 801612
DR   Cosmic; 844553
DR   Cosmic; 844812
DR   Cosmic; 876161
DR   Cosmic; 918016
DR   Cosmic; 929977
DR   Cosmic; 934543
DR   Cosmic; 1006528
DR   Cosmic; 1021862
DR   Cosmic; 1212191
DR   Cosmic; 1219095
DR   Cosmic; 1239933
DR   Cosmic; 1571754
DR   Cosmic; 1656909
DR   Cosmic; 2125205
DR   Cosmic; 2648016
DR   Cosmic; 2668270
DR   Cosmic; 2668343
DR   EGA; EGAS00001000610
DR   GEO; GSM784263
DR   GEO; GSM845555
DR   GEO; GSM844663
DR   GEO; GSM986187
DR   IARC_TP53; 1407
DR   KCLB; 90417
DR   PharmacoDB; NCIN417_1150_2019
DR   Progenetix; CVCL_1602
DR   PubChem_Cell_line; CVCL_1602
DR   Wikidata; Q54908212
RX   PubMed=1320893;
RX   PubMed=1563005;
RX   PubMed=1565469;
RX   PubMed=1845952;
RX   PubMed=2473086;
RX   PubMed=2540905;
RX   PubMed=2574988;
RX   PubMed=2985257;
RX   PubMed=2985258;
RX   PubMed=3034934;
RX   PubMed=6148444;
RX   PubMed=6270685;
RX   PubMed=6713399;
RX   PubMed=7972006;
RX   PubMed=8626706;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9744504;
RX   PubMed=10037197;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=11030152;
RX   PubMed=11414198;
RX   PubMed=12712436;
RX   PubMed=19394761;
RX   PubMed=19472407;
RX   PubMed=20164919;
RX   PubMed=20557307;
RX   PubMed=21750403;
RX   PubMed=22313637;
RX   PubMed=23716474;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26589293;
RX   PubMed=31803961;
WW   https://www.atcc.org/en/support/technical-support/faqs/nci-h60-atcc-crl-5821
CC   Characteristics: Established from a nude mouse xenograft.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=21750403).
CC   Doubling time: 26 hours (PubMed=2985258).
CC   HLA typing: A*26:01,23:01; B*08:01,08:01; C*07:01 (PubMed=25960936).
CC   HLA typing: A*23:01,26:01; B*08:01,08:01; C*07:01,07:01 (PubMed=26589293).
CC   Sequence variation: Gene fusion; HGNC; 23139; CLVS1 + HGNC; 9709; PVT1; Name(s)=PVT1-CLVS1 (PubMed=23716474).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Lys (c.1636C>A); ClinVar=VCV000013657; Zygosity=Heterozygous (PubMed=19394761).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Unspecified (PubMed=1565469; PubMed=10536175; PubMed=20557307).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: NCI-417N; Cosmic=2648016.
CC   Discontinued: ATCC; CRL-5809; true.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ATCC=CRL-5809; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10
ST   D16S539: 9
ST   D18S51: 12,13
ST   D21S11: 30,31
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 11,12
ST   D8S1179: 11,14
ST   FGA: 21
ST   Penta D: 9,13
ST   Penta E: 5
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A788 ! NCI-N231
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 39
//
RX   PubMed=1320893; DOI=10.1159/000163712;
RA   Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M.,
RA   Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M.,
RA   Burbach J.P.H.;
RT   "Expression of the vasopressin and gastrin-releasing peptide genes in
RT   small cell lung carcinoma cell lines.";
RL   Pathobiology 60:136-142(1992).
//
RX   PubMed=1563005;
RA   Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.;
RT   "Neuromedin B is present in lung cancer cell lines.";
RL   Cancer Res. 52:2732s-2736s(1992).
//
RX   PubMed=1565469;
RA   Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P.,
RA   Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F.,
RA   Linnoila R.I.;
RT   "Expression of mutant p53 proteins in lung cancer correlates with the
RT   class of p53 gene mutation.";
RL   Oncogene 7:743-749(1992).
//
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
//
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
//
RX   PubMed=2540905;
RA   Takahashi T., Obata Y., Sekido Y., Hida T., Ueda R., Watanabe H.,
RA   Ariyoshi Y., Sugiura T., Takahashi T.;
RT   "Expression and amplification of myc gene family in small cell lung
RT   cancer and its relation to biological characteristics.";
RL   Cancer Res. 49:2683-2688(1989).
//
RX   PubMed=2574988; DOI=10.1038/bjc.1989.376;
RA   Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M.,
RA   Skovsgaard T., Hansen H.H.;
RT   "In vitro evaluation of the potential of aclarubicin in the treatment
RT   of small cell carcinoma of the lung (SCCL).";
RL   Br. J. Cancer 60:838-844(1989).
//
RX   PubMed=2985257;
RA   Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J.,
RA   Moody T.W., Zweig M.H., Minna J.D.;
RT   "Establishment and identification of small cell lung cancer cell lines
RT   having classic and variant features.";
RL   Cancer Res. 45:2913-2923(1985).
//
RX   PubMed=2985258;
RA   Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.;
RT   "Characterization of variant subclasses of cell lines derived from
RT   small cell lung cancer having distinctive biochemical, morphological,
RT   and growth properties.";
RL   Cancer Res. 45:2924-2930(1985).
//
RX   PubMed=3034934; DOI=10.1002/jcb.240330405;
RA   Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.;
RT   "Oncogene amplification and chromosomal abnormalities in small cell
RT   lung cancer.";
RL   J. Cell. Biochem. 33:267-288(1987).
//
RX   PubMed=6148444; DOI=10.1093/jnci/73.4.801;
RA   Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H. Jr.,
RA   Mitchell J.B.;
RT   "Heterogeneity in the radiation survival curves and biochemical
RT   properties of human lung cancer cell lines.";
RL   J. Natl. Cancer Inst. 73:801-807(1984).
//
RX   PubMed=6270685; DOI=10.1073/pnas.78.7.4591;
RA   Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.;
RT   "Monoclonal antibodies that demonstrate specificity for several types
RT   of human lung cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981).
//
RX   PubMed=6713399;
RA   Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N.,
RA   Gazdar A.F., Minna J.D.;
RT   "Analysis of human small cell lung cancer differentiation antigens
RT   using a panel of rat monoclonal antibodies.";
RL   Cancer Res. 44:2052-2061(1984).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8626706; DOI=10.1074/jbc.271.19.11477;
RA   Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M.,
RA   Grimley C., Battey J., Mulshine J.L., Cuttitta F.;
RT   "Insulin-like growth factor expression in human cancer cell lines.";
RL   J. Biol. Chem. 271:11477-11483(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
//
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553;
RA   Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N.,
RA   Poulsen H.S.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
//
RX   PubMed=10037197;
RA   Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.;
RT   "Coexpression of transcripts encoding EPHB receptor protein tyrosine
RT   kinases and their ephrin-B ligands in human small cell lung
RT   carcinoma.";
RL   Clin. Cancer Res. 5:455-460(1999).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=12712436; DOI=10.1002/ijc.11106;
RA   Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.;
RT   "The role of RAD51 in etoposide (VP16) resistance in small cell lung
RT   cancer.";
RL   Int. J. Cancer 105:472-479(2003).
//
RX   PubMed=19394761; DOI=10.1016/j.canlet.2009.03.038;
RA   Shibata T., Kokubu A., Tsuta K., Hirohashi S.;
RT   "Oncogenic mutation of PIK3CA in small cell lung carcinoma: a
RT   potential therapeutic target pathway for chemotherapy-resistant lung
RT   cancer.";
RL   Cancer Lett. 283:203-211(2009).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=21750403; DOI=10.4161/cbt.12.7.15955;
RA   Zhang Y.-A., Maitra A., Hsieh J.-T., Rudin C.M., Peacock C.D.,
RA   Karikari C., Brekken R.A., Stastny V.A., Gao B.-N., Girard L.,
RA   Wistuba I.I., Frenkel E.P., Minna J.D., Gazdar A.F.;
RT   "Frequent detection of infectious xenotropic murine leukemia virus
RT   (XMLV) in human cultures established from mouse xenografts.";
RL   Cancer Biol. Ther. 12:617-628(2011).
//
RX   PubMed=22313637; DOI=10.4161/cbt.19238;
RA   Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A.,
RA   Igishi T., Burioka N., Nanba E., Shimizu E.;
RT   "Lack of AKT activation in lung cancer cells with EGFR mutation is a
RT   novel marker of cetuximab sensitivity.";
RL   Cancer Biol. Ther. 13:369-378(2012).
//
RX   PubMed=23716474; DOI=10.1002/gcc.22076;
RA   Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T.,
RA   Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S.,
RA   Yokota J.;
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//