ID NCI-N417 AC CVCL_1602 SY NCI-N-417; NCI N417; N-417; N417; NCIN417; NCI417N; NCI-H417; H-417; H417; NCI-N417D; N417D; N417d DR BTO; BTO_0003028 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ATCC; CRL-5809 DR BioSample; SAMN03471029 DR cancercelllines; CVCL_1602 DR ChEMBL-Cells; CHEMBL3307265 DR ChEMBL-Targets; CHEMBL613287 DR ChEMBL-Targets; CHEMBL613517 DR Cosmic; 688033 DR Cosmic; 801612 DR Cosmic; 844553 DR Cosmic; 844812 DR Cosmic; 876161 DR Cosmic; 918016 DR Cosmic; 929977 DR Cosmic; 934543 DR Cosmic; 1006528 DR Cosmic; 1021862 DR Cosmic; 1212191 DR Cosmic; 1219095 DR Cosmic; 1239933 DR Cosmic; 1571754 DR Cosmic; 1656909 DR Cosmic; 2125205 DR Cosmic; 2648016 DR Cosmic; 2668270 DR Cosmic; 2668343 DR EGA; EGAS00001000610 DR GEO; GSM784263 DR GEO; GSM844663 DR GEO; GSM845555 DR GEO; GSM986187 DR IARC_TP53; 1407 DR KCLB; 90417 DR PharmacoDB; NCIN417_1150_2019 DR Progenetix; CVCL_1602 DR PubChem_Cell_line; CVCL_1602 DR Wikidata; Q54908212 RX PubMed=1320893; RX PubMed=1563005; RX PubMed=1565469; RX PubMed=1845952; RX PubMed=2473086; RX PubMed=2540905; RX PubMed=2574988; RX PubMed=2985257; RX PubMed=2985258; RX PubMed=3034934; RX PubMed=6148444; RX PubMed=6270685; RX PubMed=6713399; RX PubMed=7972006; RX PubMed=8626706; RX PubMed=8806092; RX PubMed=8806103; RX PubMed=9744504; RX PubMed=10037197; RX PubMed=10536175; RX PubMed=11005564; RX PubMed=11030152; RX PubMed=11414198; RX PubMed=12712436; RX PubMed=19394761; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20557307; RX PubMed=21750403; RX PubMed=22313637; RX PubMed=23716474; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25960936; RX PubMed=26589293; RX PubMed=31803961; WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/nci-h60-atcc-crl-5821 CC Characteristics: Established from a nude mouse xenograft. CC Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=21750403). CC Doubling time: 26 hours (PubMed=2985258). CC HLA typing: A*26:01,23:01; B*08:01,08:01; C*07:01 (PubMed=25960936). CC HLA typing: A*23:01,26:01; B*08:01,08:01; C*07:01,07:01 (PubMed=26589293). CC Sequence variation: Gene fusion; HGNC; HGNC:23139; CLVS1 + HGNC; HGNC:9709; PVT1; Name(s)=PVT1-CLVS1 (PubMed=23716474). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Lys (c.1636C>A); ClinVar=VCV000013657; Zygosity=Heterozygous (PubMed=19394761). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Unspecified (PubMed=1565469; PubMed=10536175; PubMed=20557307). CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Misspelling: NCI-417N; Cosmic=2648016. CC Discontinued: ATCC; CRL-5809; true. CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): ATCC=CRL-5809; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 10 ST D16S539: 9 ST D18S51: 12,13 ST D21S11: 30,31 ST D3S1358: 16 ST D5S818: 13 ST D7S820: 11,12 ST D8S1179: 11,14 ST FGA: 21 ST Penta D: 9,13 ST Penta E: 5 ST TH01: 6 ST TPOX: 8 ST vWA: 17,18 DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_A788 ! NCI-N231 SX Female AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 CH CVCL_A592 ! NCI-H60 // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=8806103; DOI=10.1002/jcb.240630516; RA Johnson, Bruce E. RA Russell, Edward RA Simmons, Alfreda M. RA Phelps, Ruby M. RA Steinberg, Seth M. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RT "MYC family DNA amplification in 126 tumor cell lines from patients RT with small cell lung cancer."; RL J. Cell. Biochem. Suppl. 24:210-217(1996). // RX PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065; RA Damstrup, Lars RA Voldborg, Bjorn Gunnar Rude RA Spang-Thomsen, Mogens RA Brunner, Nils RA Poulsen, Hans Skovgaard RT "In vitro invasion of small-cell lung cancer cell lines correlates RT with expression of epidermal growth factor receptor."; RL Br. J. Cancer 78:631-640(1998). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. 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RT "Analysis of human small cell lung cancer differentiation antigens RT using a panel of rat monoclonal antibodies."; RL Cancer Res. 44:2052-2061(1984). // RX PubMed=22313637; DOI=10.4161/cbt.19238; RA Takata, Miyako RA Chikumi, Hiroki RA Miyake, Naomi RA Adachi, Kaori RA Kanamori, Yasunobu RA Yamasaki, Akira RA Igishi, Tadashi RA Burioka, Naoto RA Nanba, Eiji RA Shimizu, Eiji RT "Lack of AKT activation in lung cancer cells with EGFR mutation is a RT novel marker of cetuximab sensitivity."; RL Cancer Biol. Ther. 13:369-378(2012). // RX PubMed=11414198; DOI=10.1007/s004320000207; RA Lahm, Harald RA Andre, Sabine RA Hoeflich, Andreas RA Fischer, Jurgen R. RA Sordat, Bernard RA Kaltner, Herbert RA Wolf, Eckhard RA Gabius, Hans-Joachim RT "Comprehensive galectin fingerprinting in a panel of 61 human tumor RT cell lines by RT-PCR and its implications for diagnostic and RT therapeutic procedures."; RL J. Cancer Res. Clin. 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RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=10536175; DOI=10.3892/ijo.15.5.927; RA Fujita, Takeshi RA Kiyama, Masaharu RA Tomizawa, Yoshio RA Kohno, Takashi RA Yokota, Jun RT "Comprehensive analysis of p53 gene mutation characteristics in lung RT carcinoma with special reference to histological subtypes."; RL Int. J. Oncol. 15:927-934(1999). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=10037197; RA Tang, Xao X. RA Brodeur, Garrett M. RA Campling, Barbara G. RA Ikegaki, Naohiko RT "Coexpression of transcripts encoding EPHB receptor protein tyrosine RT kinases and their ephrin-B ligands in human small cell lung RT carcinoma."; RL Clin. Cancer Res. 5:455-460(1999). // RX PubMed=12712436; DOI=10.1002/ijc.11106; RA Hansen, Lasse Tengbjerg RA Lundin, Cecilia RA Spang-Thomsen, Mogens RA Petersen, Lone Norgard RA Helleday, Thomas RT "The role of RAD51 in etoposide (VP16) resistance in small cell lung RT cancer."; RL Int. J. 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RT "Novel antigens characteristic of neuroendocrine malignancies."; RL Cancer 67:619-633(1991). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=2985257; RA Carney, Desmond Niall RA Gazdar, Adi F. RA Bepler, Gerold RA Guccion, John G. RA Marangos, Paul J. RA Moody, Terry W. RA Zweig, Mark H. RA Minna, John D. RT "Establishment and identification of small cell lung cancer cell lines RT having classic and variant features."; RL Cancer Res. 45:2913-2923(1985). // RX PubMed=1320893; DOI=10.1159/000163712; RA Verbeeck, Marken A.E. 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RT "Frequent detection of infectious xenotropic murine leukemia virus RT (XMLV) in human cultures established from mouse xenografts."; RL Cancer Biol. Ther. 12:617-628(2011). // RX PubMed=6270685; DOI=10.1073/pnas.78.7.4591; PMCID=PMC319839; RA Cuttitta, Frank RA Rosen, Steven T. RA Gazdar, Adi F. RA Minna, John D. RT "Monoclonal antibodies that demonstrate specificity for several types RT of human lung cancer."; RL Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel, Sebastian RA Lower, Martin RA Bukur, Thomas RA Sahin, Ugur RA Castle, John C. RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=2473086; DOI=10.1242/jcs.91.1.91; RA Broers, Jos L.V. RA Rot, Mirjam Klein RA Oostendorp, Tineke RA Bepler, Gerold RA de Leij, Lou F.M.H. 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