ID   NCI-H841
AC   CVCL_1595
SY   H841; H-841; NCI-841; NCIH841
DR   CLO; CLO_0008122
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-5845
DR   BioSample; SAMN03471025
DR   BioSample; SAMN10988536
DR   cancercelllines; CVCL_1595
DR   Cell_Model_Passport; SIDM01134
DR   Cosmic; 801616
DR   Cosmic; 844564
DR   Cosmic; 876162
DR   Cosmic; 897511
DR   Cosmic; 918013
DR   Cosmic; 1021871
DR   Cosmic; 1032404
DR   Cosmic; 1219092
DR   Cosmic; 1239941
DR   Cosmic; 1891907
DR   Cosmic; 2125187
DR   Cosmic-CLP; 1240192
DR   DepMap; ACH-000292
DR   EGA; EGAS00001000978
DR   GDSC; 1240192
DR   GEO; GSM171888
DR   GEO; GSM171889
DR   GEO; GSM794303
DR   GEO; GSM827488
DR   GEO; GSM844661
DR   GEO; GSM845552
DR   GEO; GSM887449
DR   GEO; GSM888529
DR   GEO; GSM986177
DR   GEO; GSM1670269
DR   GEO; GSM1887922
DR   GEO; GSM1888004
DR   IARC_TP53; 11886
DR   KCLB; 90841
DR   LiGeA; CCLE_365
DR   LINCS_LDP; LCL-1819
DR   PharmacoDB; NCIH841_1143_2019
DR   Progenetix; CVCL_1595
DR   Wikidata; Q54908131
RX   PubMed=8784480;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=11030152;
RX   PubMed=19472407;
RX   PubMed=20215515;
RX   PubMed=20557307;
RX   PubMed=22460905;
RX   PubMed=22961666;
RX   PubMed=23716474;
RX   PubMed=25877200;
RX   PubMed=27247353;
RX   PubMed=27397505;
RX   PubMed=28766886;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31803961;
RX   PubMed=32586373;
RX   PubMed=38180245;
RX   PubMed=39154123;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Lys934Ter (c.2800A>T); Zygosity=Homozygous (Cosmic-CLP=1240192; DepMap=ACH-000292).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Ser (c.725G>C); ClinVar=VCV000647334; Zygosity=Homozygous (PubMed=10536175; PubMed=20557307; Cosmic-CLP=1240192; DepMap=ACH-000292).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.52%; Native American=0%; East Asian, North=2.66%; East Asian, South=0%; South Asian=0%; European, North=55.47%; European, South=40.35% (PubMed=30894373).
CC   Caution: Originally classified as originating from a lung small cell carcinoma, but is reclassified as a thoracic SMARCA4-deficient undifferentiated tumor based on a number of criteria (PubMed=38180245).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ATCC=CRL-5845; Cosmic-CLP=1240192; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 13
ST   D18S51: 14,18
ST   D19S433: 12,13
ST   D21S11: 29,30
ST   D2S1338: 24
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 10,13
ST   D8S1179: 8,16
ST   FGA: 22
ST   Penta D: 9,16
ST   Penta E: 5,10
ST   TH01: 6,9
ST   TPOX: 11,12
ST   vWA: 16,17
DI   NCIt; C183115; Thoracic SMARCA4-deficient undifferentiated tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 38
//
RX   PubMed=8784480; DOI=10.1159/000227600;
RA   Shinohara, Akinori
RA   Shimizu, Eiji
RA   Takada, Minoru
RA   Sone, Saburo
RT   "Lack of c-mpl proto-oncogene transcripts and growth-stimulatory
RT   effects of thrombopoietin on human small cell lung cancer cell
RT   lines.";
RL   Oncology 53:426-434(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel C.
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson, Bruce E.
RA   Russell, Edward
RA   Simmons, Alfreda M.
RA   Phelps, Ruby M.
RA   Steinberg, Seth M.
RA   Ihde, Daniel C.
RA   Gazdar, Adi F.
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita, Takeshi
RA   Kiyama, Masaharu
RA   Tomizawa, Yoshio
RA   Kohno, Takashi
RA   Yokota, Jun
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293;
RA   Kohno, Takashi
RA   Sato, Takako
RA   Takakura, Satoshi
RA   Takei, Kimiko
RA   Inoue, Kaoru
RA   Nishioka, Michiho
RA   Yokota, Jun
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922;
RA   Byers, Lauren Averett
RA   Wang, Jing
RA   Nilsson, Monique B.
RA   Fujimoto, Junya
RA   Saintigny, Pierre
RA   Yordy, John Stuart
RA   Giri, Uma
RA   Peyton, Michael
RA   Fan, You-Hong
RA   Diao, Li-Xia
RA   Masrorpour, Fatemeh
RA   Shen, Li
RA   Liu, Wen-Bin
RA   Duchemann, Boris
RA   Tumula, Praveen
RA   Bhardwaj, Vikas
RA   Welsh, James
RA   Weber, Stephanie
RA   Glisson, Bonnie S.
RA   Kalhor, Neda
RA   Wistuba, Ignacio Ivan
RA   Girard, Luc
RA   Lippman, Scott M.
RA   Mills, Gordon B.
RA   Coombes, Kevin Robert
RA   Weinstein, John N.
RA   Minna, John D.
RA   Heymach, John Victor
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277;
RA   Iwakawa, Reika
RA   Takenaka, Masataka
RA   Kohno, Takashi
RA   Shimada, Yoko
RA   Totoki, Yasushi
RA   Shibata, Tatsuhiro
RA   Tsuta, Koji
RA   Nishikawa, Ryo
RA   Noguchi, Masayuki
RA   Sato-Otsubo, Aiko
RA   Ogawa, Seishi
RA   Yokota, Jun
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Fer, Nicole
RA   Sonkin, Dmitriy
RA   Kaur, Gurmeet
RA   Monks, Anne
RA   Malik, Shakun
RA   Morris, Joel
RA   Teicher, Beverly A.
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher, Beverly A.
RA   Silvers, Thomas E.
RA   Selby, Michael
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Parchment, Ralph E.
RA   Krushkal, Julia
RA   Sonkin, Dmitriy
RA   Rubinstein, Lawrence
RA   Morris, Joel
RA   Evans, David
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal, Julia
RA   Silvers, Thomas E.
RA   Reinhold, William C.
RA   Sonkin, Dmitriy
RA   Vural, Suleyman
RA   Connelly, John
RA   Varma, Sudhir
RA   Meltzer, Paul S.
RA   Kunkel, Mark W.
RA   Rapisarda, Annamaria
RA   Evans, David
RA   Pommier, Yves
RA   Teicher, Beverly A.
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//
RX   PubMed=38180245; DOI=10.1158/1078-0432.CCR-23-2360; PMCID=PMC11061608;
RA   Ng, Jin
RA   Cai, Ling
RA   Girard, Luc
RA   Prall, Owen W.J.
RA   Rajan, Neeha Sulakshi
RA   Khoo, Christine
RA   Batrouney, Ahida
RA   Byrne, David J.
RA   Boyd, Danielle K.
RA   Kersbergen, Ariena J.
RA   Christie, Michael
RA   Minna, John D.
RA   Burr, Marian L.
RA   Sutherland, Kate D.
RT   "Molecular and pathologic characterization of YAP1-expressing small
RT   cell lung cancer cell lines leads to reclassification as
RT   SMARCA4-deficient malignancies.";
RL   Clin. Cancer Res. 30:1846-1858(2024).
//
RX   PubMed=39154123; DOI=10.1038/s41388-024-03125-x; PMCID=PMC11405284;
RA   Nguyen, Aiden
RA   Nunez, Clarissa G.
RA   Tran, Tram Anh
RA   Girard, Luc
RA   Peyton, Michael
RA   Catalan, Rodrigo
RA   Guerena, Cristina D.
RA   Avila, Kimberley
RA   Drapkin, Benjamin J.
RA   Chandra, Raghav
RA   Minna, John D.
RA   Martinez, Elisabeth D.
RT   "Jumonji histone demethylases are therapeutic targets in small cell
RT   lung cancer.";
RL   Oncogene 43:2885-2899(2024).
//