ID NCI-H841 AC CVCL_1595 SY H841; H-841; NCI-841; NCIH841 DR CLO; CLO_0008122 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-5845 DR BioSample; SAMN03471025 DR BioSample; SAMN10988536 DR cancercelllines; CVCL_1595 DR Cell_Model_Passport; SIDM01134 DR Cosmic; 801616 DR Cosmic; 844564 DR Cosmic; 876162 DR Cosmic; 897511 DR Cosmic; 918013 DR Cosmic; 1021871 DR Cosmic; 1032404 DR Cosmic; 1219092 DR Cosmic; 1239941 DR Cosmic; 1891907 DR Cosmic; 2125187 DR Cosmic-CLP; 1240192 DR DepMap; ACH-000292 DR EGA; EGAS00001000978 DR GDSC; 1240192 DR GEO; GSM171888 DR GEO; GSM171889 DR GEO; GSM794303 DR GEO; GSM827488 DR GEO; GSM844661 DR GEO; GSM845552 DR GEO; GSM887449 DR GEO; GSM888529 DR GEO; GSM986177 DR GEO; GSM1670269 DR GEO; GSM1887922 DR GEO; GSM1888004 DR IARC_TP53; 11886 DR KCLB; 90841 DR LiGeA; CCLE_365 DR LINCS_LDP; LCL-1819 DR PharmacoDB; NCIH841_1143_2019 DR Progenetix; CVCL_1595 DR Wikidata; Q54908131 RX PubMed=8784480; RX PubMed=8806092; RX PubMed=8806103; RX PubMed=10536175; RX PubMed=11005564; RX PubMed=11030152; RX PubMed=19472407; RX PubMed=20215515; RX PubMed=20557307; RX PubMed=22460905; RX PubMed=22961666; RX PubMed=23716474; RX PubMed=25877200; RX PubMed=27247353; RX PubMed=27397505; RX PubMed=28766886; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=32586373; RX PubMed=38180245; RX PubMed=39154123; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Lys934Ter (c.2800A>T); Zygosity=Homozygous (Cosmic-CLP=1240192; DepMap=ACH-000292). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Ser (c.725G>C); ClinVar=VCV000647334; Zygosity=Homozygous (PubMed=10536175; PubMed=20557307; Cosmic-CLP=1240192; DepMap=ACH-000292). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.52%; Native American=0%; East Asian, North=2.66%; East Asian, South=0%; South Asian=0%; European, North=55.47%; European, South=40.35% (PubMed=30894373). CC Caution: Originally classified as originating from a lung small cell carcinoma, but is reclassified as a thoracic SMARCA4-deficient undifferentiated tumor based on a number of criteria (PubMed=38180245). CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): ATCC=CRL-5845; Cosmic-CLP=1240192; PubMed=25877200 ST Amelogenin: X,Y ST CSF1PO: 11 ST D13S317: 12 ST D16S539: 13 ST D18S51: 14,18 ST D19S433: 12,13 ST D21S11: 29,30 ST D2S1338: 24 ST D3S1358: 17 ST D5S818: 11,12 ST D7S820: 10,13 ST D8S1179: 8,16 ST FGA: 22 ST Penta D: 9,16 ST Penta E: 5,10 ST TH01: 6,9 ST TPOX: 11,12 ST vWA: 16,17 DI NCIt; C183115; Thoracic SMARCA4-deficient undifferentiated tumor OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 51Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 38 // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=8806103; DOI=10.1002/jcb.240630516; RA Johnson, Bruce E. RA Russell, Edward RA Simmons, Alfreda M. RA Phelps, Ruby M. RA Steinberg, Seth M. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RT "MYC family DNA amplification in 126 tumor cell lines from patients RT with small cell lung cancer."; RL J. Cell. Biochem. Suppl. 24:210-217(1996). // RX PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526; RA Krushkal, Julia RA Silvers, Thomas E. RA Reinhold, William C. RA Sonkin, Dmitriy RA Vural, Suleyman RA Connelly, John RA Varma, Sudhir RA Meltzer, Paul S. RA Kunkel, Mark W. RA Rapisarda, Annamaria RA Evans, David RA Pommier, Yves RA Teicher, Beverly A. RT "Epigenome-wide DNA methylation analysis of small cell lung cancer RT cell lines suggests potential chemotherapy targets."; RL Clin. Epigenetics 12:93.1-93.28(2020). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277; RA Iwakawa, Reika RA Takenaka, Masataka RA Kohno, Takashi RA Shimada, Yoko RA Totoki, Yasushi RA Shibata, Tatsuhiro RA Tsuta, Koji RA Nishikawa, Ryo RA Noguchi, Masayuki RA Sato-Otsubo, Aiko RA Ogawa, Seishi RA Yokota, Jun RT "Genome-wide identification of genes with amplification and/or fusion RT in small cell lung cancer."; RL Genes Chromosomes Cancer 52:802-816(2013). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=10536175; DOI=10.3892/ijo.15.5.927; RA Fujita, Takeshi RA Kiyama, Masaharu RA Tomizawa, Yoshio RA Kohno, Takashi RA Yokota, Jun RT "Comprehensive analysis of p53 gene mutation characteristics in lung RT carcinoma with special reference to histological subtypes."; RL Int. J. Oncol. 15:927-934(1999). // RX PubMed=8784480; DOI=10.1159/000227600; RA Shinohara, Akinori RA Shimizu, Eiji RA Takada, Minoru RA Sone, Saburo RT "Lack of c-mpl proto-oncogene transcripts and growth-stimulatory RT effects of thrombopoietin on human small cell lung cancer cell RT lines."; RL Oncology 53:426-434(1996). // RX PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882; RA Teicher, Beverly A. RA Silvers, Thomas E. RA Selby, Michael RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Parchment, Ralph E. RA Krushkal, Julia RA Sonkin, Dmitriy RA Rubinstein, Lawrence RA Morris, Joel RA Evans, David RT "Small cell lung carcinoma cell line screen of etoposide/carboplatin RT plus a third agent."; RL Cancer Med. 6:1952-1964(2017). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa, Reika RA Kohno, Takashi RA Enari, Masatoshi RA Kiyono, Tohru RA Yokota, Jun RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293; RA Kohno, Takashi RA Sato, Takako RA Takakura, Satoshi RA Takei, Kimiko RA Inoue, Kaoru RA Nishioka, Michiho RA Yokota, Jun RT "Mutation and expression of the DCC gene in human lung cancer."; RL Neoplasia 2:300-305(2000). // RX PubMed=39154123; DOI=10.1038/s41388-024-03125-x; PMCID=PMC11405284; RA Nguyen, Aiden RA Nunez, Clarissa G. RA Tran, Tram Anh RA Girard, Luc RA Peyton, Michael RA Catalan, Rodrigo RA Guerena, Cristina D. RA Avila, Kimberley RA Drapkin, Benjamin J. RA Chandra, Raghav RA Minna, John D. RA Martinez, Elisabeth D. RT "Jumonji histone demethylases are therapeutic targets in small cell RT lung cancer."; RL Oncogene 43:2885-2899(2024). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco, Raquel RA Iwakawa, Reika RA Tang, Mo-Ying RA Kohno, Takashi RA Angulo, Barbara RA Pio, Ruben RA Montuenga, Luis M. RA Minna, John D. RA Yokota, Jun RA Sanchez-Cespedes, Montse RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers, Lauren Averett RA Wang, Jing RA Nilsson, Monique B. RA Fujimoto, Junya RA Saintigny, Pierre RA Yordy, John Stuart RA Giri, Uma RA Peyton, Michael RA Fan, You-Hong RA Diao, Li-Xia RA Masrorpour, Fatemeh RA Shen, Li RA Liu, Wen-Bin RA Duchemann, Boris RA Tumula, Praveen RA Bhardwaj, Vikas RA Welsh, James RA Weber, Stephanie RA Glisson, Bonnie S. RA Kalhor, Neda RA Wistuba, Ignacio Ivan RA Girard, Luc RA Lippman, Scott M. RA Mills, Gordon B. RA Coombes, Kevin Robert RA Weinstein, John N. RA Minna, John D. RA Heymach, John Victor RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282; RA Polley, Eric C. RA Kunkel, Mark W. RA Evans, David RA Silvers, Thomas E. RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Selby, Michael RA Connelly, John RA Harris, Erik RA Fer, Nicole RA Sonkin, Dmitriy RA Kaur, Gurmeet RA Monks, Anne RA Malik, Shakun RA Morris, Joel RA Teicher, Beverly A. RT "Small cell lung cancer screen of oncology drugs, investigational RT agents, and gene and microRNA expression."; RL J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016). // RX PubMed=11030152; DOI=10.1038/sj.onc.1203815; RA Modi, Sanjay RA Kubo, Akihito RA Oie, Herbert Kazuto RA Coxon, Amy B. RA Rehmatulla, Ahad RA Kaye, Frederic J. RT "Protein expression of the RB-related gene family and SV40 large T RT antigen in mesothelioma and lung cancer."; RL Oncogene 19:4632-4639(2000). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=38180245; DOI=10.1158/1078-0432.CCR-23-2360; PMCID=PMC11061608; RA Ng, Jin RA Cai, Ling RA Girard, Luc RA Prall, Owen W.J. RA Rajan, Neeha Sulakshi RA Khoo, Christine RA Batrouney, Ahida RA Byrne, David J. RA Boyd, Danielle K. RA Kersbergen, Ariena J. RA Christie, Michael RA Minna, John D. RA Burr, Marian L. RA Sutherland, Kate D. RT "Molecular and pathologic characterization of YAP1-expressing small RT cell lung cancer cell lines leads to reclassification as RT SMARCA4-deficient malignancies."; RL Clin. Cancer Res. 30:1846-1858(2024). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //