ID   NCI-H735
AC   CVCL_1585
SY   H735; H-735
DR   CLO; CLO_0008112
DR   ATCC; CRL-5978
DR   BioSample; SAMN03472630
DR   cancercelllines; CVCL_1585
DR   Cosmic; 688029
DR   Cosmic; 844559
DR   Cosmic; 877363
DR   Cosmic; 1152475
DR   GDSC; 688029
DR   GEO; GSM986184
DR   GEO; GSM1887938
DR   GEO; GSM1888027
DR   PharmacoDB; NCIH735_1134_2019
DR   Progenetix; CVCL_1585
DR   Wikidata; Q54908115
RX   PubMed=8626706;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=11030152;
RX   PubMed=27247353;
RX   PubMed=28766886;
RX   PubMed=31803961;
RX   PubMed=32586373;
CC   Population: Caucasian.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
ST   Source(s): ATCC=CRL-5978
ST   Amelogenin: X
ST   CSF1PO: 12,14
ST   D13S317: 11,14
ST   D16S539: 14
ST   D18S51: 12
ST   D19S433: 13,14
ST   D21S11: 29,30.2
ST   D2S1338: 17,23
ST   D3S1358: 16
ST   D5S818: 9,11
ST   D7S820: 8,11
ST   D8S1179: 13,15
ST   FGA: 23
ST   Penta D: 10,16
ST   Penta E: 5
ST   TH01: 8,9.3
ST   TPOX: 11
ST   vWA: 18,19
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=8626706; DOI=10.1074/jbc.271.19.11477;
RA   Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M.,
RA   Grimley C., Battey J., Mulshine J.L., Cuttitta F.;
RT   "Insulin-like growth factor expression in human cancer cell lines.";
RL   J. Biol. Chem. 271:11477-11483(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J.,
RA   Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N.,
RA   Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.;
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C.,
RA   Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L.,
RA   Morris J., Evans D.;
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal J., Silvers T.E., Reinhold W.C., Sonkin D., Vural S.,
RA   Connelly J., Varma S., Meltzer P.S., Kunkel M.W., Rapisarda A.,
RA   Evans D., Pommier Y., Teicher B.A.;
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//