ID   NCI-H719
AC   CVCL_1582
SY   H719; H-719
DR   CLO; CLO_0008109
DR   ATCC; CRL-5837
DR   BioSample; SAMN03471750
DR   cancercelllines; CVCL_1582
DR   ChEMBL-Cells; CHEMBL3308551
DR   ChEMBL-Targets; CHEMBL2366184
DR   Cosmic; 688028
DR   Cosmic; 844558
DR   Cosmic; 877362
DR   Cosmic; 924242
DR   Cosmic; 980934
DR   Cosmic; 1032401
DR   Cosmic; 1152474
DR   Cosmic; 2125256
DR   GDSC; 924242
DR   GEO; GSM1887919
DR   GEO; GSM1888001
DR   IARC_TP53; 27194
DR   KCLB; 90719
DR   LINCS_LDP; LCL-1860
DR   PharmacoDB; NCIH719_1131_2019
DR   PubChem_Cell_line; CVCL_1582
DR   Wikidata; Q54908111
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=11030152;
RX   PubMed=20164919;
RX   PubMed=27247353;
RX   PubMed=28766886;
RX   PubMed=31803961;
RX   PubMed=32586373;
CC   Part of: Small cell lung cancer p53 hotspot mutation cell panel (ATCC TCP-2040).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (ATCC=CRL-5837).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Donor information: Established from a 100 packs per year smoker (ATCC=CRL-5837).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-5837; KCLB=90719
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 9
ST   D18S51: 14,15
ST   D19S433: 13,14
ST   D21S11: 30,32.2
ST   D2S1338: 16,20
ST   D3S1358: 14
ST   D5S818: 13
ST   D7S820: 10
ST   D8S1179: 11
ST   FGA: 20
ST   Penta D: 13,14
ST   Penta E: 16,17
ST   TH01: 8,9
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J.,
RA   Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N.,
RA   Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.;
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C.,
RA   Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L.,
RA   Morris J., Evans D.;
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal J., Silvers T.E., Reinhold W.C., Sonkin D., Vural S.,
RA   Connelly J., Varma S., Meltzer P.S., Kunkel M.W., Rapisarda A.,
RA   Evans D., Pommier Y., Teicher B.A.;
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//