ID NCI-H69 AC CVCL_1579 SY NCI-H-69; NCI H69; H69; H-69; NCIH69; NCI-HUT-69; H69/P; NCI-H69C; H69C; H69c DR BTO; BTO_0003022 DR CLO; CLO_0003609 DR CLO; CLO_0008105 DR EFO; EFO_0002300 DR CLDB; cl1552 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; HTB-119 DR BioSample; SAMN03473085 DR BioSample; SAMN10988132 DR cancercelllines; CVCL_1579 DR CCRID; 1101HUM-PUMC000358 DR Cell_Model_Passport; SIDM01121 DR ChEMBL-Cells; CHEMBL3307712 DR ChEMBL-Targets; CHEMBL614805 DR CLS; 300185 DR Cosmic; 688027 DR Cosmic; 713879 DR Cosmic; 755459 DR Cosmic; 801610 DR Cosmic; 808518 DR Cosmic; 844545 DR Cosmic; 844817 DR Cosmic; 876167 DR Cosmic; 877351 DR Cosmic; 918010 DR Cosmic; 929160 DR Cosmic; 1006522 DR Cosmic; 1021849 DR Cosmic; 1152461 DR Cosmic; 1175859 DR Cosmic; 1212189 DR Cosmic; 1219096 DR Cosmic; 1239934 DR Cosmic; 1434964 DR Cosmic; 1571755 DR Cosmic; 1609516 DR Cosmic; 1995588 DR Cosmic; 1998272 DR Cosmic; 2125215 DR Cosmic; 2239080 DR Cosmic; 2648017 DR Cosmic; 2668341 DR Cosmic-CLP; 688027 DR DepMap; ACH-000358 DR ECACC; 91091802 DR EGA; EGAS00001000978 DR GDSC; 688027 DR GEO; GSM169443 DR GEO; GSM380498 DR GEO; GSM536334 DR GEO; GSM784197 DR GEO; GSM794269 DR GEO; GSM827305 DR GEO; GSM844659 DR GEO; GSM845550 DR GEO; GSM887442 DR GEO; GSM888522 DR GEO; GSM1670258 DR GEO; GSM1887950 DR GEO; GSM1887978 DR IARC_TP53; 328 DR IGRhCellID; NCIH69 DR IZSLER; BS TCL 172 DR KCLB; 30119 DR LiGeA; CCLE_927 DR LINCS_LDP; LCL-1859 DR NCI-DTP; NCI-H69 DR PharmacoDB; NCIH69_1129_2019 DR PRIDE; PXD011896 DR PRIDE; PXD015270 DR PRIDE; PXD030304 DR Progenetix; CVCL_1579 DR PubChem_Cell_line; CVCL_1579 DR Wikidata; Q38568854 RX PubMed=1662924; RX PubMed=1845952; RX PubMed=1847845; RX PubMed=2388294; RX PubMed=2473086; RX PubMed=2574988; RX PubMed=2594029; RX PubMed=2985257; RX PubMed=2985258; RX PubMed=2986243; RX PubMed=3034934; RX PubMed=3335022; RX PubMed=6108156; RX PubMed=6148444; RX PubMed=6270685; RX PubMed=6272398; RX PubMed=6713399; RX PubMed=7736387; RX PubMed=7903701; RX PubMed=8263009; RX PubMed=8626706; RX PubMed=8712684; RX PubMed=8784480; RX PubMed=8806092; RX PubMed=8806103; RX PubMed=9212023; RX PubMed=9413215; RX PubMed=9559344; RX PubMed=9744504; RX PubMed=9815546; RX PubMed=10037197; RX PubMed=10358721; RX PubMed=10536175; RX PubMed=11005564; RX PubMed=11030152; RX PubMed=11414198; RX PubMed=12569360; RX PubMed=17426248; RX PubMed=19394761; RX PubMed=19446745; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20557307; RX PubMed=20615970; RX PubMed=22460905; RX PubMed=22961666; RX PubMed=23716474; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27247353; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=28766886; RX PubMed=30038707; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=32351780; RX PubMed=32586373; RX PubMed=34439128; RX PubMed=35839778; RX PubMed=39154123; WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/htb-119-morphology-and-culture-conditions WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Doubling time: 56.0 hours (PubMed=1662924). CC HLA typing: A*02:01,23:01; B*42:02,58:05; C*07:01,14:02 (PubMed=26589293). CC HLA typing: A*02:01:01,23:01:01; B*01:01:01,51:01:01; C*07:01:01,14:02:01; DPB1*01:01:01G,03:01:01G; DQA1*03:01:01;03:03:01; DQB1*03:02:01; DRB1*04:04:01,04:05:01 (CLS=300185). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (PubMed=19394761; ATCC=HTB-119). CC Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (PubMed=8263009; PubMed=2594029; ATCC=HTB-119). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (PubMed=8263009; PubMed=10536175; PubMed=20557307; ATCC=HTB-119). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.79%; Native American=0%; East Asian, North=1.48%; East Asian, South=0%; South Asian=0.42%; European, North=61.96%; European, South=35.34% (PubMed=30894373). CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): ATCC=HTB-119; CCRID=1101HUM-PUMC000358; CLS=300185; Cosmic-CLP=688027; ECACC=91091802; KCLB=30119; PubMed=25877200 ST Amelogenin: X (CLS=300185) ST Amelogenin: X,Y (ATCC=HTB-119; CCRID=1101HUM-PUMC000358; Cosmic-CLP=688027; ECACC=91091802; KCLB=30119; PubMed=25877200) ST CSF1PO: 10,12 (CLS=300185; ECACC=91091802; KCLB=30119) ST CSF1PO: 10,12,13 (ATCC=HTB-119; CCRID=1101HUM-PUMC000358) ST CSF1PO: 10,13 (Cosmic-CLP=688027; PubMed=25877200) ST D13S317: 12 ST D16S539: 11 ST D18S51: 12 (CLS=300185) ST D18S51: 12,15 (ATCC=HTB-119; CCRID=1101HUM-PUMC000358; PubMed=25877200) ST D19S433: 15,15.2 ST D21S11: 30,31.2 ST D2S1338: 17 ST D3S1358: 16 ST D5S818: 11,13 ST D7S820: 9 ST D8S1179: 13 ST FGA: 24 ST Penta D: 9,11 ST Penta E: 12 ST TH01: 8,9 ST TPOX: 10 ST vWA: 16,17 (ATCC=HTB-119; CCRID=1101HUM-PUMC000358; CLS=300185; ECACC=91091802; KCLB=30119) ST vWA: 17 (Cosmic-CLP=688027; PubMed=25877200) DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 55Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 50 CH CVCL_0B21 ! H69/BCNU CH CVCL_0B22 ! H69/DAU CH CVCL_X029 ! H69/Txl CH CVCL_AZ78 ! H69/VDS CH CVCL_0B23 ! H69/VP CH CVCL_RS65 ! H69R CH CVCL_2466 ! H69V CH CVCL_S830 ! H69VZ CH CVCL_A537 ! NCI-H249 CH CVCL_2137 ! NCI-H69/CPR CH CVCL_E4CP ! NCI-H69/IFN-gamma CH CVCL_E4CQ ! NCI-H69/IL2 CH CVCL_2138 ! NCI-H69/LX10 CH CVCL_2139 ! NCI-H69/LX20 CH CVCL_2140 ! NCI-H69/LX4 CH CVCL_3513 ! NCI-H69AR CH CVCL_3058 ! NCI-H69VCR/R CH CVCL_A590 ! NCI-N592 // RX PubMed=32351780; DOI=10.7717/peerj.8779; PMCID=PMC7183755; RA Wu, Jing-Yu RA Hao, Zhi-Fang RA Ma, Chen RA Li, Peng-Fei RA Dang, Liu-Yi RA Sun, Shi-Sheng RT "Comparative proteogenomics profiling of non-small and small lung RT carcinoma cell lines using mass spectrometry."; RL PeerJ 8:e8779.1-e8779.19(2020). // RX PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0; RA Mulligan, Lois M. RA Timmer, Tineke RA Ivanchuk, Stacey M. RA Campling, Barbara G. RA Young, Leah C. RA Rabbitts, Pamela Helen RA Sundaresan, Vasi RA Hofstra, Robert M.W. RA Eng, Charis RT "Investigation of the genes for RET and its ligand complex, GDNF/GFR RT alpha-I, in small cell lung carcinoma."; RL Genes Chromosomes Cancer 21:326-332(1998). // RX PubMed=19446745; DOI=10.1016/j.cancergencyto.2009.01.016; RA Salido, Marta RA Arriola, Edurne RA Carracedo, Alma RA Canadas, Israel RA Rovira, Ana RA Espinet, Blanca RA Rojo, Federico RA Arumi-Uria, Montserrat RA Serrano, Sergi RA Albanell, Joan RA Sole, Francesc RT "Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung RT cancer cell lines by spectral karyotyping."; RL Cancer Genet. Cytogenet. 191:97-101(2009). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=30038707; DOI=10.18632/oncotarget.25642; PMCID=PMC6049873; RA Du, Li-Qin RA Zhao, Zhen-Ze RA Suraokar, Milind Bhalchandra RA Shelton, Spencer S. RA Ma, Xiu-Ye RA Hsiao, Tzu-Hung RA Minna, John D. RA Wistuba, Ignacio Ivan RA Pertsemlidis, Alexander RT "LMO1 functions as an oncogene by regulating TTK expression and RT correlates with neuroendocrine differentiation of lung cancer."; RL Oncotarget 9:29601-29618(2018). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=8806103; DOI=10.1002/jcb.240630516; RA Johnson, Bruce E. RA Russell, Edward RA Simmons, Alfreda M. RA Phelps, Ruby M. RA Steinberg, Seth M. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RT "MYC family DNA amplification in 126 tumor cell lines from patients RT with small cell lung cancer."; RL J. Cell. Biochem. Suppl. 24:210-217(1996). // RX PubMed=1847845; DOI=10.1007/BF00685110; RA Sasaki, Yasutsuna RA Shinkai, Tetsu RA Eguchi, Kenji RA Tamura, Tomohide RA Ohe, Yuichiro RA Ohmori, Tohru RA Saijo, Nagahiro RT "Prediction of the antitumor activity of new platinum analogs based on RT their ex vivo pharmacodynamics as determined by bioassay."; RL Cancer Chemother. Pharmacol. 27:263-270(1991). // RX PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526; RA Krushkal, Julia RA Silvers, Thomas E. RA Reinhold, William C. RA Sonkin, Dmitriy RA Vural, Suleyman RA Connelly, John RA Varma, Sudhir RA Meltzer, Paul S. RA Kunkel, Mark W. RA Rapisarda, Annamaria RA Evans, David RA Pommier, Yves RA Teicher, Beverly A. RT "Epigenome-wide DNA methylation analysis of small cell lung cancer RT cell lines suggests potential chemotherapy targets."; RL Clin. Epigenetics 12:93.1-93.28(2020). // RX PubMed=2388294; DOI=10.1093/jnci/82.17.1420; RA McLemore, Theodore L. RA Litterst, Charles L. RA Coudert, Bruno P. RA Liu, Mark C. RA Hubbard, Walter C. RA Adelberg, Steven RA Czerwinski, Maciej J. RA McMahon, Noreen A. RA Eggleston, Joseph C. RA Boyd, Michael R. RT "Metabolic activation of 4-ipomeanol in human lung, primary pulmonary RT carcinomas, and established human pulmonary carcinoma cell lines."; RL J. Natl. Cancer Inst. 82:1420-1426(1990). // RX PubMed=6272398; DOI=10.1126/science.6272398; RA Moody, Terry W. RA Pert, Candace Beebe RA Gazdar, Adi F. RA Carney, Desmond Niall RA Minna, John D. RT "High levels of intracellular bombesin characterize human small-cell RT lung carcinoma."; RL Science 214:1246-1248(1981). // RX PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065; RA Damstrup, Lars RA Voldborg, Bjorn Gunnar Rude RA Spang-Thomsen, Mogens RA Brunner, Nils RA Poulsen, Hans Skovgaard RT "In vitro invasion of small-cell lung cancer cell lines correlates RT with expression of epidermal growth factor receptor."; RL Br. J. Cancer 78:631-640(1998). // RX PubMed=3335022; RA Alley, Michael Curtis RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=6713399; RA Rosen, Steven T. RA Mulshine, James L. RA Cuttitta, Frank RA Fedorko, Joseph RA Carney, Desmond Niall RA Gazdar, Adi F. RA Minna, John D. RT "Analysis of human small cell lung cancer differentiation antigens RT using a panel of rat monoclonal antibodies."; RL Cancer Res. 44:2052-2061(1984). // RX PubMed=11414198; DOI=10.1007/s004320000207; RA Lahm, Harald RA Andre, Sabine RA Hoeflich, Andreas RA Fischer, Jurgen R. RA Sordat, Bernard RA Kaltner, Herbert RA Wolf, Eckhard RA Gabius, Hans-Joachim RT "Comprehensive galectin fingerprinting in a panel of 61 human tumor RT cell lines by RT-PCR and its implications for diagnostic and RT therapeutic procedures."; RL J. Cancer Res. Clin. Oncol. 127:375-386(2001). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=2574988; DOI=10.1038/bjc.1989.376; PMCID=PMC2247271; RA Jensen, Peter Buhl RA Vindelov, Lars L. RA Roed, Henrik RA Demant, Erland Johannes Frederik RA Sehested, Maxwell RA Skovsgaard, Torben RA Hansen, Heine Hoi RT "In vitro evaluation of the potential of aclarubicin in the treatment RT of small cell carcinoma of the lung (SCCL)."; RL Br. J. Cancer 60:838-844(1989). // RX PubMed=10358721; DOI=10.18926/AMO/31626; RA Matsushita, Akio RA Tabata, Masahiro RA Ueoka, Hiroshi RA Kiura, Katsuyuki RA Shibayama, Takuo RA Aoe, Keisuke RA Kohara, Hiroyuki RA Harada, Mine RT "Establishment of a drug sensitivity panel using human lung cancer RT cell lines."; RL Acta Med. Okayama 53:67-75(1999). // RX PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277; RA Iwakawa, Reika RA Takenaka, Masataka RA Kohno, Takashi RA Shimada, Yoko RA Totoki, Yasushi RA Shibata, Tatsuhiro RA Tsuta, Koji RA Nishikawa, Ryo RA Noguchi, Masayuki RA Sato-Otsubo, Aiko RA Ogawa, Seishi RA Yokota, Jun RT "Genome-wide identification of genes with amplification and/or fusion RT in small cell lung cancer."; RL Genes Chromosomes Cancer 52:802-816(2013). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=34439128; DOI=10.3390/cancers13163972; PMCID=PMC8391533; RA Fahrmann, Johannes Francois RA Katayama, Hiroyuki RA Irajizad, Ehsan RA Chakraborty, Ashish RA Kato, Taketo RA Mao, Xiang-Ying RA Park, Soyoung RA Murage, Eunice RA Rusling, Leona A. RA Yu, Chuan-Yih RA Cai, Yi-Ning RA Hsiao, Fu-Chung RA Dennison, Jennifer B. RA Tran, Hai T. RA Ostrin, Edwin Justin RA Wilson, David Oscar RA Yuan, Jian-Min RA Vykoukal, Jody V. RA Hanash, Samir M. RT "Plasma based protein signatures associated with small cell lung RT cancer."; RL Cancers (Basel) 13:3972.1-3972.17(2021). // RX PubMed=10536175; DOI=10.3892/ijo.15.5.927; RA Fujita, Takeshi RA Kiyama, Masaharu RA Tomizawa, Yoshio RA Kohno, Takashi RA Yokota, Jun RT "Comprehensive analysis of p53 gene mutation characteristics in lung RT carcinoma with special reference to histological subtypes."; RL Int. J. Oncol. 15:927-934(1999). // RX PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367; RA Olejniczak, Edward T. RA Van Sant, Charles RA Anderson, Mark G. RA Wang, Gang RA Tahir, Stephen K. RA Sauter, Guido RA Lesniewski, Rick RA Semizarov, Dimitri RT "Integrative genomic analysis of small-cell lung carcinoma reveals RT correlates of sensitivity to bcl-2 antagonists and uncovers novel RT chromosomal gains."; RL Mol. Cancer Res. 5:331-339(2007). // RX PubMed=8712684; RA Khan, Muhammad Zalaan RA McNicol, Anne Marie RA Freshney, Robert Ian RT "Tumorigenicity, invasion and metastasis of the small cell lung cancer RT cell line NCI-H69 and two derivative lines MOG-H69V and MOG-H69VZ."; RL Anticancer Res. 16:1659-1669(1996). // RX PubMed=8784480; DOI=10.1159/000227600; RA Shinohara, Akinori RA Shimizu, Eiji RA Takada, Minoru RA Sone, Saburo RT "Lack of c-mpl proto-oncogene transcripts and growth-stimulatory RT effects of thrombopoietin on human small cell lung cancer cell RT lines."; RL Oncology 53:426-434(1996). // RX PubMed=2594029; DOI=10.1056/NEJM198912213212501; RA Yandell, David William RA Campbell, Tracey A. RA Dayton, Siri H. RA Petersen, Robert RA Walton, David RA Little, John Bertram RA McConkie-Rosell, Allyn RA Buckley, Edward G. RA Dryja, Thaddeus Peter RT "Oncogenic point mutations in the human retinoblastoma gene: their RT application to genetic counseling."; RL N. Engl. J. Med. 321:1689-1695(1989). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=10037197; RA Tang, Xao X. RA Brodeur, Garrett M. RA Campling, Barbara G. RA Ikegaki, Naohiko RT "Coexpression of transcripts encoding EPHB receptor protein tyrosine RT kinases and their ephrin-B ligands in human small cell lung RT carcinoma."; RL Clin. Cancer Res. 5:455-460(1999). // RX PubMed=9815546; RA Campling, Barbara G. RA Young, Leah C. RA Baer, Kathy A. RA Lam, Yuk-Miu RA Deeley, Roger G. RA Cole, Susan P.C. RA Gerlach, James H. RT "Expression of the MRP and MDR1 multidrug resistance genes in small RT cell lung cancer."; RL Clin. Cancer Res. 3:115-122(1997). // RX PubMed=8263009; DOI=10.1007/BF01202192; RA Kashii, Tatsuhiko RA Mizushima, Yutaka RA Monno, Satoshi RA Nakagawa, Keiko RA Kobayashi, Masashi RT "Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility RT genes in human lung cancer cell lines by the polymerase chain RT reaction/single-strand conformation polymorphism method."; RL J. Cancer Res. Clin. Oncol. 120:143-148(1994). // RX PubMed=7736387; DOI=10.1002/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q; RA Campling, Barbara G. RA Sarda, Inder R. RA Baer, Kathy A. RA Pang, Stephen C. RA Baker, Heather M. RA Lofters, Wycliffe S. RA Flynn, T. Geoffrey RT "Secretion of atrial natriuretic peptide and vasopressin by small cell RT lung cancer."; RL Cancer 75:2442-2451(1995). // RX PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882; RA Teicher, Beverly A. RA Silvers, Thomas E. RA Selby, Michael RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Parchment, Ralph E. RA Krushkal, Julia RA Sonkin, Dmitriy RA Rubinstein, Lawrence RA Morris, Joel RA Evans, David RT "Small cell lung carcinoma cell line screen of etoposide/carboplatin RT plus a third agent."; RL Cancer Med. 6:1952-1964(2017). // RX PubMed=1662924; RA Khan, Muhammad Zalaan RA Freshney, Robert Ian RA Moir, Alison M.B. RA Merry, Stephen RA Plumb, John A. RA McNicol, Anne Marie RT "Identification and characterisation in vitro of cells with a non-SCLC RT cell-like phenotype derived from a continuous SCLC cell line."; RL Anticancer Res. 11:1687-1695(1991). // RX PubMed=9413215; RA Yamane, Hiromishi RA Kiura, Katsuyuki RA Tabata, Masahiro RA Bessho, Akihiro RA Tsuchida, Tadashi RA Motoda, Kinya RA Hiraki, Akio RA Ueoka, Hiroshi RA Harada, Mine RT "Small cell lung cancer can express CD34 antigen."; RL Anticancer Res. 17:3627-3632(1997). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293; RA Kohno, Takashi RA Sato, Takako RA Takakura, Satoshi RA Takei, Kimiko RA Inoue, Kaoru RA Nishioka, Michiho RA Yokota, Jun RT "Mutation and expression of the DCC gene in human lung cancer."; RL Neoplasia 2:300-305(2000). // RX PubMed=3034934; DOI=10.1002/jcb.240330405; RA Ibson, J.M. RA Waters, Jonathan J. RA Twentyman, Peter Roy RA Bleehen, Norman Montague RA Rabbitts, Pamela Helen RT "Oncogene amplification and chromosomal abnormalities in small cell RT lung cancer."; RL J. Cell. Biochem. 33:267-288(1987). // RX PubMed=2986243; DOI=10.1007/978-3-642-82372-5_4; RA Whang-Peng, Jacqueline RA Lee, Elaine C. RT "Cytogenetics of human small cell lung cancer."; RL Recent Results Cancer Res. 97:37-46(1985). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa, Reika RA Kohno, Takashi RA Enari, Masatoshi RA Kiyono, Tohru RA Yokota, Jun RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=8626706; DOI=10.1074/jbc.271.19.11477; RA Quinn, Kathryn A. RA Treston, Anthony M. RA Unsworth, Edward J. RA Miller, Mae-Jean RA Vos, Michele RA Grimley, Chris RA Battey, James RA Mulshine, James L. RA Cuttitta, Frank RT "Insulin-like growth factor expression in human cancer cell lines."; RL J. Biol. Chem. 271:11477-11483(1996). // RX PubMed=6108156; RA Gazdar, Adi F. RA Carney, Desmond Niall RA Russell, Edward K. RA Sims, Harvie Lee RA Baylin, Stephen Bruce RA Bunn, Paul A. Jr. RA Guccion, John G. RA Minna, John D. RT "Establishment of continuous, clonable cultures of small-cell RT carcinoma of lung which have amine precursor uptake and RT decarboxylation cell properties."; RL Cancer Res. 40:3502-3507(1980). // RX PubMed=19394761; DOI=10.1016/j.canlet.2009.03.038; RA Shibata, Tatsuhiro RA Kokubu, Akiko RA Tsuta, Koji RA Hirohashi, Setsuo RT "Oncogenic mutation of PIK3CA in small cell lung carcinoma: a RT potential therapeutic target pathway for chemotherapy-resistant lung RT cancer."; RL Cancer Lett. 283:203-211(2009). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco, Raquel RA Iwakawa, Reika RA Tang, Mo-Ying RA Kohno, Takashi RA Angulo, Barbara RA Pio, Ruben RA Montuenga, Luis M. RA Minna, John D. RA Yokota, Jun RA Sanchez-Cespedes, Montse RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=39154123; DOI=10.1038/s41388-024-03125-x; PMCID=PMC11405284; RA Nguyen, Aiden RA Nunez, Clarissa G. RA Tran, Tram Anh RA Girard, Luc RA Peyton, Michael RA Catalan, Rodrigo RA Guerena, Cristina D. RA Avila, Kimberley RA Drapkin, Benjamin J. RA Chandra, Raghav RA Minna, John D. RA Martinez, Elisabeth D. RT "Jumonji histone demethylases are therapeutic targets in small cell RT lung cancer."; RL Oncogene 43:2885-2899(2024). // RX PubMed=6148444; DOI=10.1093/jnci/73.4.801; RA Morstyn, George RA Russo, Angelo RA Carney, Desmond Niall RA Karawya, Essam RA Wilson, Samuel H. Jr. RA Mitchell, James B. RT "Heterogeneity in the radiation survival curves and biochemical RT properties of human lung cancer cell lines."; RL J. Natl. Cancer Inst. 73:801-807(1984). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers, Lauren Averett RA Wang, Jing RA Nilsson, Monique B. RA Fujimoto, Junya RA Saintigny, Pierre RA Yordy, John Stuart RA Giri, Uma RA Peyton, Michael RA Fan, You-Hong RA Diao, Li-Xia RA Masrorpour, Fatemeh RA Shen, Li RA Liu, Wen-Bin RA Duchemann, Boris RA Tumula, Praveen RA Bhardwaj, Vikas RA Welsh, James RA Weber, Stephanie RA Glisson, Bonnie S. RA Kalhor, Neda RA Wistuba, Ignacio Ivan RA Girard, Luc RA Lippman, Scott M. RA Mills, Gordon B. RA Coombes, Kevin Robert RA Weinstein, John N. RA Minna, John D. RA Heymach, John Victor RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y; RA Broers, Jos L.V. RA Mijnheere, Eddy P. RA Rot, Mirjam Klein RA Schaart, Gert RA Sijlmans, Alfred RA Boerman, Otto C. RA Ramaekers, Frans C.S. RT "Novel antigens characteristic of neuroendocrine malignancies."; RL Cancer 67:619-633(1991). // RX PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9; RA Krarup, Marianne RA Poulsen, Hans Skovgaard RA Spang-Thomsen, Mogens RT "Cellular radiosensitivity of small-cell lung cancer cell lines."; RL Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282; RA Polley, Eric C. RA Kunkel, Mark W. RA Evans, David RA Silvers, Thomas E. RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Selby, Michael RA Connelly, John RA Harris, Erik RA Fer, Nicole RA Sonkin, Dmitriy RA Kaur, Gurmeet RA Monks, Anne RA Malik, Shakun RA Morris, Joel RA Teicher, Beverly A. RT "Small cell lung cancer screen of oncology drugs, investigational RT agents, and gene and microRNA expression."; RL J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016). // RX PubMed=2985257; RA Carney, Desmond Niall RA Gazdar, Adi F. RA Bepler, Gerold RA Guccion, John G. RA Marangos, Paul J. RA Moody, Terry W. RA Zweig, Mark H. RA Minna, John D. RT "Establishment and identification of small cell lung cancer cell lines RT having classic and variant features."; RL Cancer Res. 45:2913-2923(1985). // RX PubMed=11030152; DOI=10.1038/sj.onc.1203815; RA Modi, Sanjay RA Kubo, Akihito RA Oie, Herbert Kazuto RA Coxon, Amy B. RA Rehmatulla, Ahad RA Kaye, Frederic J. RT "Protein expression of the RB-related gene family and SV40 large T RT antigen in mesothelioma and lung cancer."; RL Oncogene 19:4632-4639(2000). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=12569360; DOI=10.1038/sj.onc.1206106; RA Funakoshi, Toshiki RA Tachibana, Isao RA Hoshida, Yoshihiko RA Kimura, Hiromi RA Takeda, Yoshito RA Kijima, Takashi RA Nishino, Kazumi RA Goto, Hiroyuki RA Yoneda, Tsutomu RA Kumagai, Toru RA Osaki, Tadashi RA Hayashi, Seiji RA Aozasa, Katsuyuki RA Kawase, Ichiro RT "Expression of tetraspanins in human lung cancer cells: frequent RT downregulation of CD9 and its contribution to cell motility in small RT cell lung cancer."; RL Oncogene 22:674-687(2003). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=6270685; DOI=10.1073/pnas.78.7.4591; PMCID=PMC319839; RA Cuttitta, Frank RA Rosen, Steven T. RA Gazdar, Adi F. RA Minna, John D. RT "Monoclonal antibodies that demonstrate specificity for several types RT of human lung cancer."; RL Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=2473086; DOI=10.1242/jcs.91.1.91; RA Broers, Jos L.V. RA Rot, Mirjam Klein RA Oostendorp, Tineke RA Bepler, Gerold RA de Leij, Lou F.M.H. RA Carney, Desmond Niall RA Vooijs, Gijsbert Peter RA Ramaekers, Frans C.S. RT "Spontaneous changes in intermediate filament protein expression RT patterns in lung cancer cell lines."; RL J. Cell Sci. 91:91-108(1988). // RX PubMed=7903701; DOI=10.1093/jnci/86.2.110; RA Barrand, Margery A. RA Heppell-Parton, Amanda C. RA Wright, Karen A. RA Rabbitts, Pamela Helen RA Twentyman, Peter Roy RT "A 190-kilodalton protein overexpressed in RT non-P-glycoprotein-containing multidrug-resistant cells and its RT relationship to the MRP gene."; RL J. Natl. Cancer Inst. 86:110-117(1994). // RX PubMed=2985258; RA Gazdar, Adi F. RA Carney, Desmond Niall RA Nau, Marion M. RA Minna, John D. RT "Characterization of variant subclasses of cell lines derived from RT small cell lung cancer having distinctive biochemical, morphological, RT and growth properties."; RL Cancer Res. 45:2924-2930(1985). // RX PubMed=20615970; DOI=10.1073/pnas.1008132107; PMCID=PMC2919980; RA Voortman, Johannes RA Lee, Jih-Hsiang RA Killian, Jonathan Keith RA Suuriniemi, Miia RA Wang, Yong-Hong RA Lucchi, Marco RA Smith, William I. Jr. RA Meltzer, Paul S. RA Wang, Yi-Song RA Giaccone, Giuseppe RT "Array comparative genomic hybridization-based characterization of RT genetic alterations in pulmonary neuroendocrine tumors."; RL Proc. Natl. Acad. Sci. 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