ID   NCI-H69
AC   CVCL_1579
SY   NCI-H-69; NCI H69; H69; H-69; NCIH69; NCI-HUT-69; H69/P; NCI-H69C; H69C; H69c
DR   BTO; BTO:0003022
DR   CLO; CLO_0003609
DR   CLO; CLO_0008105
DR   EFO; EFO_0002300
DR   CLDB; cl1552
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-119
DR   BioSample; SAMN03473085
DR   BioSample; SAMN10988132
DR   CCRID; 1101HUM-PUMC000358
DR   Cell_Model_Passport; SIDM01121
DR   ChEMBL-Cells; CHEMBL3307712
DR   ChEMBL-Targets; CHEMBL614805
DR   CLS; 300185
DR   Cosmic; 688027
DR   Cosmic; 713879
DR   Cosmic; 755459
DR   Cosmic; 801610
DR   Cosmic; 808518
DR   Cosmic; 844545
DR   Cosmic; 844817
DR   Cosmic; 876167
DR   Cosmic; 877351
DR   Cosmic; 918010
DR   Cosmic; 929160
DR   Cosmic; 1006522
DR   Cosmic; 1021849
DR   Cosmic; 1152461
DR   Cosmic; 1175859
DR   Cosmic; 1212189
DR   Cosmic; 1219096
DR   Cosmic; 1239934
DR   Cosmic; 1434964
DR   Cosmic; 1571755
DR   Cosmic; 1609516
DR   Cosmic; 1995588
DR   Cosmic; 1998272
DR   Cosmic; 2125215
DR   Cosmic; 2239080
DR   Cosmic; 2648017
DR   Cosmic; 2668341
DR   Cosmic-CLP; 688027
DR   DepMap; ACH-000358
DR   ECACC; 91091802
DR   EGA; EGAS00001000978
DR   GDSC; 688027
DR   GEO; GSM169443
DR   GEO; GSM380498
DR   GEO; GSM536334
DR   GEO; GSM784197
DR   GEO; GSM794269
DR   GEO; GSM827305
DR   GEO; GSM845550
DR   GEO; GSM844659
DR   GEO; GSM887442
DR   GEO; GSM888522
DR   GEO; GSM1670258
DR   IARC_TP53; 328
DR   KCLB; 30119
DR   LiGeA; CCLE_927
DR   PharmacoDB; NCIH69_1129_2019
DR   PRIDE; PXD011896
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1579
DR   PubChem_Cell_line; CVCL_1579
DR   Wikidata; Q38568854
RX   PubMed=1662924;
RX   PubMed=1845952;
RX   PubMed=1847845;
RX   PubMed=2388294;
RX   PubMed=2473086;
RX   PubMed=2574988;
RX   PubMed=2594029;
RX   PubMed=2985257;
RX   PubMed=2985258;
RX   PubMed=2986243;
RX   PubMed=3034934;
RX   PubMed=3335022;
RX   PubMed=6108156;
RX   PubMed=6148444;
RX   PubMed=6270685;
RX   PubMed=6713399;
RX   PubMed=7736387;
RX   PubMed=7903701;
RX   PubMed=8626706;
RX   PubMed=8712684;
RX   PubMed=8784480;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9212023;
RX   PubMed=9413215;
RX   PubMed=9559344;
RX   PubMed=9744504;
RX   PubMed=9815546;
RX   PubMed=10037197;
RX   PubMed=10358721;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=11030152;
RX   PubMed=11414198;
RX   PubMed=12569360;
RX   PubMed=17426248;
RX   PubMed=19394761;
RX   PubMed=19472407;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20557307;
RX   PubMed=22460905;
RX   PubMed=22961666;
RX   PubMed=23716474;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30038707;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31803961;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Doubling time: 56.0 hours (PubMed=1662924).
CC   HLA typing: A*02:01:01,23:01:01; B*01:01:01,51:01:01; C*07:01:01,14:02:01; DPB1*01:01:01G,03:01:01G; DQA1*03:01:01;03:03:01; DQB1*03:02:01; DRB1*04:04:01,04:05:01 (CLS).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (PubMed=19394761; ATCC).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (PubMed=2594029; ATCC).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (PubMed=10536175; PubMed=20557307; ATCC).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.79%; Native American=0%; East Asian, North=1.48%; East Asian, South=0%; South Asian=0.42%; European, North=61.96%; European, South=35.34% (PubMed=30894373).
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): ATCC; CCRID; CLS; Cosmic-CLP; ECACC; KCLB; PubMed=25877200
ST   Amelogenin: X (CLS)
ST   Amelogenin: X,Y (ATCC; CCRID; Cosmic-CLP; ECACC; KCLB; PubMed=25877200)
ST   CSF1PO: 10,12,13 (CCRID)
ST   CSF1PO: 10,13 (Cosmic-CLP; PubMed=25877200)
ST   D13S317: 12
ST   D16S539: 11
ST   D18S51: 12 (CLS)
ST   D18S51: 12,15 (CCRID; PubMed=25877200)
ST   D19S433: 15,15.2
ST   D21S11: 30,31.2
ST   D2S1338: 17
ST   D3S1358: 16
ST   D5S818: 11,13
ST   D7S820: 9
ST   D8S1179: 13
ST   FGA: 24
ST   Penta D: 9,11
ST   Penta E: 12
ST   TH01: 8,9
ST   TPOX: 10
ST   vWA: 17 (Cosmic-CLP; PubMed=25877200)
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 15-12-22; Version: 41
RX   PubMed=1662924;
RA   Khan M.Z., Freshney R.I., Murray A.M.B., Merry S., Plumb J.A.,
RA   McNicol A.M.;
RT   "Identification and characterisation in vitro of cells with a non-SCLC
RT   cell-like phenotype derived from a continuous SCLC cell line.";
RL   Anticancer Res. 11:1687-1695(1991).
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T.,
RA   Saijo N.;
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
RX   PubMed=2388294; DOI=10.1093/jnci/82.17.1420;
RA   McLemore T.L., Litterst C.L., Coudert B.P., Liu M.C., Hubbard W.C.,
RA   Adelberg S., Czerwinski M.J., McMahon N.A., Eggleston J.C., Boyd M.R.;
RT   "Metabolic activation of 4-ipomeanol in human lung, primary pulmonary
RT   carcinomas, and established human pulmonary carcinoma cell lines.";
RL   J. Natl. Cancer Inst. 82:1420-1426(1990).
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
RX   PubMed=2574988; DOI=10.1038/bjc.1989.376;
RA   Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M.,
RA   Skovsgaard T., Hansen H.H.;
RT   "In vitro evaluation of the potential of aclarubicin in the treatment
RT   of small cell carcinoma of the lung (SCCL).";
RL   Br. J. Cancer 60:838-844(1989).
RX   PubMed=2594029; DOI=10.1056/NEJM198912213212501;
RA   Yandell D.W., Campbell T.A., Dayton S.H., Petersen R., Walton D.,
RA   Little J.B., McConkie-Rosell A., Buckley E.G., Dryja T.P.;
RT   "Oncogenic point mutations in the human retinoblastoma gene: their
RT   application to genetic counseling.";
RL   N. Engl. J. Med. 321:1689-1695(1989).
RX   PubMed=2985257;
RA   Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J.,
RA   Moody T.W., Zweig M.H., Minna J.D.;
RT   "Establishment and identification of small cell lung cancer cell lines
RT   having classic and variant features.";
RL   Cancer Res. 45:2913-2923(1985).
RX   PubMed=2985258;
RA   Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.;
RT   "Characterization of variant subclasses of cell lines derived from
RT   small cell lung cancer having distinctive biochemical, morphological,
RT   and growth properties.";
RL   Cancer Res. 45:2924-2930(1985).
RX   PubMed=2986243; DOI=10.1007/978-3-642-82372-5_4;
RA   Whang-Peng J., Lee E.C.;
RT   "Cytogenetics of human small cell lung cancer.";
RL   Recent Results Cancer Res. 97:37-46(1985).
RX   PubMed=3034934; DOI=10.1002/jcb.240330405;
RA   Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.;
RT   "Oncogene amplification and chromosomal abnormalities in small cell
RT   lung cancer.";
RL   J. Cell. Biochem. 33:267-288(1987).
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
RX   PubMed=6108156;
RA   Gazdar A.F., Carney D.N., Russell E.K., Sims H.L., Baylin S.B.,
RA   Bunn P.A. Jr., Guccion J.G., Minna J.D.;
RT   "Establishment of continuous, clonable cultures of small-cell
RT   carcinoma of lung which have amine precursor uptake and
RT   decarboxylation cell properties.";
RL   Cancer Res. 40:3502-3507(1980).
RX   PubMed=6148444; DOI=10.1093/jnci/73.4.801;
RA   Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H.,
RA   Mitchell J.B.;
RT   "Heterogeneity in the radiation survival curves and biochemical
RT   properties of human lung cancer cell lines.";
RL   J. Natl. Cancer Inst. 73:801-807(1984).
RX   PubMed=6270685; DOI=10.1073/pnas.78.7.4591;
RA   Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.;
RT   "Monoclonal antibodies that demonstrate specificity for several types
RT   of human lung cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981).
RX   PubMed=6713399;
RA   Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N.,
RA   Gazdar A.F., Minna J.D.;
RT   "Analysis of human small cell lung cancer differentiation antigens
RT   using a panel of rat monoclonal antibodies.";
RL   Cancer Res. 44:2052-2061(1984).
RX   PubMed=7736387; DOI=10.1002/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q;
RA   Campling B.G., Sarda I.R., Baer K.A., Pang S.C., Baker H.M.,
RA   Lofters W.S., Flynn T.G.;
RT   "Secretion of atrial natriuretic peptide and vasopressin by small cell
RT   lung cancer.";
RL   Cancer 75:2442-2451(1995).
RX   PubMed=7903701; DOI=10.1093/jnci/86.2.110;
RA   Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H.,
RA   Twentyman P.R.;
RT   "A 190-kilodalton protein overexpressed in
RT   non-P-glycoprotein-containing multidrug-resistant cells and its
RT   relationship to the MRP gene.";
RL   J. Natl. Cancer Inst. 86:110-117(1994).
RX   PubMed=8626706; DOI=10.1074/jbc.271.19.11477;
RA   Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M.,
RA   Grimley C., Battey J., Mulshine J.L., Cuttitta F.;
RT   "Insulin-like growth factor expression in human cancer cell lines.";
RL   J. Biol. Chem. 271:11477-11483(1996).
RX   PubMed=8712684;
RA   Khan M.Z., McNicol A.M., Freshney R.I.;
RT   "Tumorigenicity, invasion and metastasis of the small cell lung cancer
RT   cell line NCI-H69 and two derivative lines MOG-H69V and MOG-H69VZ.";
RL   Anticancer Res. 16:1659-1669(1996).
RX   PubMed=8784480; DOI=10.1159/000227600;
RA   Shinohara A., Shimizu E., Takada M., Sone S.;
RT   "Lack of c-mpl proto-oncogene transcripts and growth-stimulatory
RT   effects of thrombopoietin on human small cell lung cancer cell
RT   lines.";
RL   Oncology 53:426-434(1996).
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
RX   PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9;
RA   Krarup M., Poulsen H.S., Spang-Thomsen M.;
RT   "Cellular radiosensitivity of small-cell lung cancer cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997).
RX   PubMed=9413215;
RA   Yamane H., Kiura K., Tabata M., Bessho A., Tsuchida T., Motoda K.,
RA   Hiraki A., Ueoka H., Harada M.;
RT   "Small cell lung cancer can express CD34 antigen.";
RL   Anticancer Res. 17:3627-3632(1997).
RX   PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0;
RA   Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C.,
RA   Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.;
RT   "Investigation of the genes for RET and its ligand complex, GDNF/GFR
RT   alpha-I, in small cell lung carcinoma.";
RL   Genes Chromosomes Cancer 21:326-332(1998).
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553;
RA   Damstrup L., Rude Voldborg B., Spang-Thomsen M., Brunner N.,
RA   Skovgaard Poulsen H.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
RX   PubMed=9815546;
RA   Campling B.G., Young L.C., Baer K.A., Lam Y.-M., Deeley R.G.,
RA   Cole S.P.C., Gerlach J.H.;
RT   "Expression of the MRP and MDR1 multidrug resistance genes in small
RT   cell lung cancer.";
RL   Clin. Cancer Res. 3:115-122(1997).
RX   PubMed=10037197;
RA   Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.;
RT   "Coexpression of transcripts encoding EPHB receptor protein tyrosine
RT   kinases and their ephrin-B ligands in human small cell lung
RT   carcinoma.";
RL   Clin. Cancer Res. 5:455-460(1999).
RX   PubMed=10358721; DOI=10.18926/AMO/31626;
RA   Matsushita A., Tabata M., Ueoka H., Kiura K., Shibayama T., Aoe K.,
RA   Kohara H., Harada M.;
RT   "Establishment of a drug sensitivity panel using human lung cancer
RT   cell lines.";
RL   Acta Med. Okayama 53:67-75(1999).
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
RX   PubMed=12569360; DOI=10.1038/sj.onc.1206106;
RA   Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y.,
RA   Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T.,
RA   Hayashi S., Aozasa K., Kawase I.;
RT   "Expression of tetraspanins in human lung cancer cells: frequent
RT   downregulation of CD9 and its contribution to cell motility in small
RT   cell lung cancer.";
RL   Oncogene 22:674-687(2003).
RX   PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367;
RA   Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K.,
RA   Sauter G., Lesniewski R., Semizarov D.;
RT   "Integrative genomic analysis of small-cell lung carcinoma reveals
RT   correlates of sensitivity to bcl-2 antagonists and uncovers novel
RT   chromosomal gains.";
RL   Mol. Cancer Res. 5:331-339(2007).
RX   PubMed=19394761; DOI=10.1016/j.canlet.2009.03.038;
RA   Shibata T., Kokubu A., Tsuta K., Hirohashi S.;
RT   "Oncogenic mutation of PIK3CA in small cell lung carcinoma: a
RT   potential therapeutic target pathway for chemotherapy-resistant lung
RT   cancer.";
RL   Cancer Lett. 283:203-211(2009).
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112;
RA   Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P.,
RA   Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F.,
RA   Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J.,
RA   Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L.,
RA   Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D.,
RA   Heymach J.V.;
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
RX   PubMed=23716474; DOI=10.1002/gcc.22076;
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