ID NCI-H508 AC CVCL_1564 SY NCI H508; NCIH508; H508; H-508 DR CLO; CLO_0008091 DR EFO; EFO_0002294 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ATCC; CCL-253 DR BioSample; SAMN03471384 DR BioSample; SAMN10987662 DR cancercelllines; CVCL_1564 DR CCRID; 1101HUM-PUMC000411 DR Cell_Model_Passport; SIDM00777 DR ChEMBL-Cells; CHEMBL4632323 DR ChEMBL-Targets; CHEMBL4632330 DR CLS; 305107 DR ColonAtlas; NCIH508 DR Cosmic; 685870 DR Cosmic; 908442 DR Cosmic; 1479606 DR Cosmic; 1565529 DR Cosmic; 1708418 DR Cosmic; 2647533 DR Cosmic; 2841372 DR Cosmic-CLP; 908442 DR DepMap; ACH-000360 DR GDSC; 908442 DR GEO; GSM513916 DR GEO; GSM514303 DR GEO; GSM741253 DR GEO; GSM887431 DR GEO; GSM888511 DR GEO; GSM1448142 DR GEO; GSM1670245 DR GEO; GSM2550010 DR IARC_TP53; 21574 DR IZSLER; BS TCL 214 DR KCLB; 10253 DR LiGeA; CCLE_864 DR PharmacoDB; NCIH508_1115_2019 DR PRIDE; PXD005235 DR PRIDE; PXD030304 DR Progenetix; CVCL_1564 DR PubChem_Cell_line; CVCL_1564 DR SKY/M-FISH/CGH; 5012 DR Wikidata; Q54908070 RX PubMed=3479249; RX PubMed=8806092; RX PubMed=8806095; RX PubMed=12068308; RX PubMed=19927377; RX PubMed=20164919; RX PubMed=20570890; RX PubMed=20606684; RX PubMed=22460905; RX PubMed=24042735; RX PubMed=25623215; RX PubMed=25926053; RX PubMed=25984343; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28683746; RX PubMed=28854368; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Doubling time: 32 hours (PubMed=25984343). CC HLA typing: A*01:01,02:01; B*08:01,51:01; C*07:01,14:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; PubMed=28683746; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly596Arg (c.1786G>C); ClinVar=VCV000375943; Zygosity=Heterozygous (PubMed=12068308; PubMed=20570890; PubMed=24042735; PubMed=28683746; ATCC=CCL-253). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (PubMed=28683746; ATCC=CCL-253). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=28683746). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.01%; Native American=0%; East Asian, North=3.05%; East Asian, South=0%; South Asian=0%; European, North=58.76%; European, South=38.18% (PubMed=30894373). CC Discontinued: CLS; 305107; true. CC Derived from site: Metastatic; Abdominal wall; UBERON=UBERON_0003697. ST Source(s): ATCC=CCL-253; Cosmic-CLP=908442; KCLB=10253; PubMed=25926053 ST Amelogenin: X ST CSF1PO: 11,12 ST D13S317: 8,12 ST D16S539: 12 ST D18S51: 18 ST D19S433: 14 ST D21S11: 29,32.2 (PubMed=25926053) ST D21S11: 29,32.2,33.2 (ATCC=CCL-253) ST D2S1338: 18,19,27 ST D3S1358: 14,17 ST D5S818: 12 ST D7S820: 8,12 ST D8S1179: 12 ST FGA: 24,25 ST Penta D: 12 ST Penta E: 10,12 ST TH01: 9,9.3 ST TPOX: 8,11 ST vWA: 15,16 DI NCIt; C5543; Cecum adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 55Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 39 CH CVCL_A2CF ! NCI-H508 R1 Cetux CH CVCL_A2CG ! NCI-H508 R2 Cetux // RX PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028; RA Bracht, Karin RA Nicholls, Angela M. RA Liu, Ying RA Bodmer, Walter Fred RT "5-fluorouracil response in a large panel of colorectal cancer cell RT lines is associated with mismatch repair deficiency."; RL Br. J. Cancer 103:340-346(2010). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010; PMCID=PMC5583477; RA Roumeliotis, Theodoros I. RA Williams, Steven P. RA Goncalves, Emanuel RA Alsinet, Clara RA Del Castillo Velasco-Herrera, Martin RA Aben, Nanne RA Ghavidel, Fatemeh Zamanzad RA Michaut, Magali RA Schubert, Michael RA Price, Stacey RA Wright, James C. RA Yu, Lu RA Yang, Mi RA Dienstmann, Rodrigo RA Guinney, Justin H. RA Beltrao, Pedro RA Brazma, Alvis RA Pardo, Mercedes RA Stegle, Oliver RA Adams, David J. RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Choudhary, Jyoti S. RT "Genomic determinants of protein abundance variation in colorectal RT cancer cells."; RL Cell Rep. 20:2201-2214(2017). // RX PubMed=25926053; DOI=10.1038/ncomms8002; RA Medico, Enzo RA Russo, Mariangela RA Picco, Gabriele RA Cancelliere, Carlotta RA Valtorta, Emanuele RA Corti, Giorgio RA Buscarino, Michela RA Isella, Claudio RA Lamba, Simona RA Martinoglio, Barbara RA Veronese, Silvio RA Siena, Salvatore RA Sartore-Bianchi, Andrea RA Beccuti, Marco RA Mottolese, Marcella RA Linnebacher, Michael RA Cordero, Francesca RA Di Nicolantonio, Federica RA Bardelli, Alberto RT "The molecular landscape of colorectal cancer cell lines unveils RT clinically actionable kinase targets."; RL Nat. Commun. 6:7002.1-7002.10(2015). // RX PubMed=3479249; RA Park, Jae-Gahb RA Oie, Herbert Kazuto RA Sugarbaker, Paul Hendrick RA Henslee, Jerry G. RA Chen, Tchaw-Ren RA Johnson, Bruce E. RA Gazdar, Adi F. RT "Characteristics of cell lines established from human colorectal RT carcinoma."; RL Cancer Res. 47:6710-6718(1987). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathryn RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne Margaret RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514; RA Janakiraman, Manickam RA Vakiani, Efsevia RA Zeng, Zhao-Shi RA Pratilas, Christine A. RA Taylor, Barry Stephen RA Chitale, Dhananjay RA Halilovic, Ensar RA Wilson, Manda RA Huberman, Kety RA Ricarte Filho, Julio Cezar Marques RA Persaud, Yogindra RA Levine, Douglas A. RA Fagin, James Alexander RA Jhanwar, Suresh C. RA Mariadason, John M. RA Lash, Alex RA Ladanyi, Marc RA Saltz, Leonard B. RA Heguy, Adriana RA Paty, Philip B. RA Solit, David B. RT "Genomic and biological characterization of exon 4 KRAS mutations in RT human cancer."; RL Cancer Res. 70:5901-5911(2010). // RX PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225; RA Ahmed, Deeqa RA Eide, Peter W. RA Eilertsen, Ina A. RA Danielsen, Stine A. RA Eknaes, Mette RA Hektoen, Merete RA Lind, Guro Elisabeth RA Lothe, Ragnhild Adelheid RT "Epigenetic and genetic features of 24 colon cancer cell lines."; RL Oncogenesis 2:e71.1-e71.8(2013). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350; RA Knutsen, Turid RA Padilla-Nash, Hesed Maria RA Wangsa, Danny RA Barenboim-Stapleton, Linda RA Camps, Jordi RA McNeil, Nicole E. RA Difilippantonio, Michael J. RA Ried, Thomas RT "Definitive molecular cytogenetic characterization of 15 colorectal RT cancer cell lines."; RL Genes Chromosomes Cancer 49:204-223(2010). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=8806095; DOI=10.1002/jcb.240630508; RA Park, Jae-Gahb RA Gazdar, Adi F. RT "Biology of colorectal and gastric cancer cell lines."; RL J. Cell. Biochem. Suppl. 24:131-141(1996). // RX PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998; RA Berg, Kaja Christine Graue RA Eide, Peter W. RA Eilertsen, Ina A. RA Johannessen, Bjarne RA Bruun, Jarle RA Danielsen, Stine A. RA Bjornslett, Merete RA Meza-Zepeda, Leonardo Andres RA Eknaes, Mette RA Lind, Guro Elisabeth RA Myklebost, Ola RA Skotheim, Rolf Inge RA Sveen, Anita RA Lothe, Ragnhild Adelheid RT "Multi-omics of 34 colorectal cancer cell lines -- a resource for RT biomedical studies."; RL Mol. Cancer 16:116.1-116.16(2017). // RX PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821; RA Arena, Sabrina RA Bellosillo, Beatriz RA Siravegna, Giulia RA Martinez, Alejandro RA Canadas, Israel RA Lazzari, Luca RA Ferruz, Noelia RA Russo, Mariangela RA Misale, Sandra RA Gonzalez, Iria RA Iglesias, Mar RA Gavilan, Elena RA Corti, Giorgio RA Hobor, Sebastijan RA Crisafulli, Giovanni RA Salido, Marta RA Sanchez, Juan RA Dalmases, Alba RA Bellmunt, Joaquim RA De Fabritiis, Gianni RA Rovira, Ana RA Di Nicolantonio, Federica RA Albanell, Joan RA Bardelli, Alberto RA Montagut, Clara RT "Emergence of multiple EGFR extracellular mutations during cetuximab RT treatment in colorectal cancer."; RL Clin. Cancer Res. 21:2157-2166(2015). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). //