ID NCI-H226 AC CVCL_1544 SY NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 DR BTO; BTO_0003008 DR CLO; CLO_0008068 DR EFO; EFO_0002285 DR AddexBio; C0016011/4916 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-5826 DR BioGRID_ORCS_Cell_line; 960 DR BioSample; SAMN03471987 DR BioSample; SAMN10987668 DR cancercelllines; CVCL_1544 DR CCRID; 3101HUMTCHu235 DR CCRID; 4201HUM-CCTCC00634 DR Cell_Model_Passport; SIDM00139 DR ChEMBL-Cells; CHEMBL3307697 DR ChEMBL-Targets; CHEMBL614740 DR CLS; 305091 DR Cosmic; 733816 DR Cosmic; 875850 DR Cosmic; 877259 DR Cosmic; 877402 DR Cosmic; 886388 DR Cosmic; 903570 DR Cosmic; 905941 DR Cosmic; 931374 DR Cosmic; 974291 DR Cosmic; 980961 DR Cosmic; 1006539 DR Cosmic; 1028953 DR Cosmic; 1032433 DR Cosmic; 1047100 DR Cosmic; 1092618 DR Cosmic; 1152497 DR Cosmic; 1175863 DR Cosmic; 1188585 DR Cosmic; 1219111 DR Cosmic; 1239951 DR Cosmic; 1305346 DR Cosmic; 1312331 DR Cosmic; 1436011 DR Cosmic; 1481544 DR Cosmic; 1802319 DR Cosmic; 1870270 DR Cosmic; 1963326 DR Cosmic; 1995565 DR Cosmic; 1998460 DR Cosmic; 2060522 DR Cosmic; 2560228 DR Cosmic; 2664122 DR Cosmic; 2772152 DR Cosmic-CLP; 905941 DR DepMap; ACH-000367 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR ENCODE; ENCBS328RVB DR ENCODE; ENCBS986NWY DR FANTOM5_SSTAR; 10846-111E9 DR GDSC; 905941 DR GEO; GSM2123 DR GEO; GSM50213 DR GEO; GSM50276 DR GEO; GSM62965 DR GEO; GSM206486 DR GEO; GSM274785 DR GEO; GSM274821 DR GEO; GSM743452 DR GEO; GSM750820 DR GEO; GSM794278 DR GEO; GSM799340 DR GEO; GSM799403 DR GEO; GSM844640 DR GEO; GSM844641 DR GEO; GSM844642 DR GEO; GSM847074 DR GEO; GSM887416 DR GEO; GSM888495 DR GEO; GSM1153411 DR GEO; GSM1178441 DR GEO; GSM1178442 DR GEO; GSM1178443 DR GEO; GSM1181351 DR GEO; GSM1374728 DR GEO; GSM1374729 DR GEO; GSM1374730 DR GEO; GSM1670227 DR GEO; GSM2124673 DR IARC_TP53; 515 DR IARC_TP53; 21406 DR IARC_TP53; 23624 DR IGRhCellID; NCIH226 DR KCLB; 90226 DR LiGeA; CCLE_131 DR LINCS_LDP; LCL-1597 DR Lonza; 839 DR NCI-DTP; NCI-H226 DR PharmacoDB; NCIH226_1082_2019 DR PRIDE; PXD005942 DR PRIDE; PXD005946 DR PRIDE; PXD030304 DR Progenetix; CVCL_1544 DR PubChem_Cell_line; CVCL_1544 DR SKY/M-FISH/CGH; 2802 DR Wikidata; Q54907948 RX PubMed=1311061; RX PubMed=1568228; RX PubMed=2041050; RX PubMed=2386953; RX PubMed=3335022; RX PubMed=6272398; RX PubMed=8806092; RX PubMed=8806101; RX PubMed=8956792; RX PubMed=9331090; RX PubMed=9488600; RX PubMed=9649128; RX PubMed=10700174; RX PubMed=11030152; RX PubMed=11369051; RX PubMed=15748285; RX PubMed=16187286; RX PubMed=17088437; RX PubMed=17332333; RX PubMed=17458138; RX PubMed=18083107; RX PubMed=19372543; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20557307; RX PubMed=22068913; RX PubMed=22336246; RX PubMed=22347499; RX PubMed=22384151; RX PubMed=22460905; RX PubMed=22628656; RX PubMed=22961666; RX PubMed=23856246; RX PubMed=23933261; RX PubMed=24002593; RX PubMed=24279929; RX PubMed=24670534; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25902174; RX PubMed=26589293; RX PubMed=27377824; RX PubMed=27397505; RX PubMed=27807467; RX PubMed=28196595; RX PubMed=29681454; RX PubMed=29718670; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=31978347; RX PubMed=35839778; RX PubMed=38861359; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm WW Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=10 WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/nci-h226-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR39 cancer cell line panel. CC Part of: KuDOS 95 cell line panel. CC Part of: MD Anderson Cell Lines Project. CC Part of: NCI-60 cancer cell line panel. CC Part of: NCI-7 clinical proteomics reference material cell line panel. CC Population: Caucasian. CC Doubling time: 43 hours (PubMed=9488600); 52 hours (PubMed=29681454); 61 hours (NCI-DTP=NCI-H226). CC HLA typing: A*01:01:01,24:02:01; B*07,39; C*07:02:01,12:03:01; DPB1*02:01:02,04:01; DQB1*05:02:01,06:02; DRB1*15:01:01,16:01:01 (PubMed=15748285). CC HLA typing: A*01:01,24:02; B*07:02,39:01; C*07:02,12:03; DQB1*06:13,06:13; DRB1*15:01,15:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (ATCC=CRL-5826). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=1568228; PubMed=20557307). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Metabolomics. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; Fluorescent probe library screening. CC Omics: Proteomics. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; CNV analysis. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=0.16%; East Asian, South=0.88%; South Asian=1.48%; European, North=65.62%; European, South=31.86% (PubMed=30894373). CC Caution: Indicated to have a TP53 p.Arg158Leu (c.473G>T) mutation according to PubMed=1311061, but no TP53 mutation detected according to PubMed=20557307, CCLE and Cosmic-CLP. CC Discontinued: KCLB; 90226; probable. CC Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): AddexBio=C0016011/4916; ATCC=CRL-5826; CCRID; Cosmic-CLP=905941; PubMed=19372543; PubMed=25877200 ST Amelogenin: X,Y ST CSF1PO: 10,11 ST D12S391: 22 ST D13S317: 13,14 ST D16S539: 9,12 ST D18S51: 16 ST D19S433: 15 ST D21S11: 29,32.2 ST D2S1338: 25 ST D2S441: 14 ST D3S1358: 16 ST D5S818: 11,12 ST D6S1043: 13,18 ST D7S820: 8,10 ST D8S1179: 14,15 ST FGA: 20,23 ST Penta D: 9,10 ST Penta E: 12,15 ST TH01: 8,9.3 ST TPOX: 8 (PubMed=19372543) ST TPOX: 8,11 (AddexBio=C0016011/4916; ATCC=CRL-5826; CCRID; Cosmic-CLP=905941; PubMed=25877200) ST vWA: 17 DI NCIt; C45662; Pleural epithelioid mesothelioma DI ORDO; Orphanet_50251; Pleural mesothelioma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 48 CH CVCL_VK08 ! NCI-H226b CH CVCL_AX73 ! NCI-H226Br // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786; RA Varma, Sudhir RA Pommier, Yves RA Sunshine, Margot RA Weinstein, John N. RA Reinhold, William C. RT "High resolution copy number variation data in the NCI-60 cancer cell RT lines from whole genome microarrays accessible through CellMiner."; RL PLoS ONE 9:e92047.1-e92047.15(2014). // RX PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832; RA Ikediobi, Ogechi N. RA Davies, Helen R. RA Bignell, Graham Robert RA Edkins, Sarah RA Stevens, Claire RA O'Meara, Sarah RA Santarius, Thomas RA Avis, Tim RA Barthorpe, Syd RA Brackenbury, Lisa RA Buck, Gemma RA Butler, Adam P. RA Clements, Jody RA Cole, Jennifer RA Dicks, Ed RA Forbes, Simon RA Gray, Kristian RA Halliday, Kelly RA Harrison, Rachel RA Hills, Katy RA Hinton, Jonathan RA Hunter, Chris RA Jenkinson, Andy RA Jones, David RA Kosmidou, Vivian RA Lugg, Richard RA Menzies, Andrew RA Mironenko, Tatiana RA Parker, Adrian RA Perry, Janet RA Raine, Keiran Martin RA Richardson, David RA Shepherd, Rebecca RA Small, Alex RA Smith, Raffaella RA Solomon, Helen RA Stephens, Philip J. RA Teague, Jon W. RA Tofts, Calli RA Varian, Jennifer RA Webb, Tony RA West, Sofie RA Widaa, Sara RA Yates, Andy RA Reinhold, William C. RA Weinstein, John N. RA Stratton, Michael Rudolf RA Futreal, P. Andrew RA Wooster, Richard RT "Mutation analysis of 24 known cancer genes in the NCI-60 cell line RT set."; RL Mol. Cancer Ther. 5:2606-2612(2006). // RX PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339; RA Okabe, Takafumi RA Okamoto, Isamu RA Tamura, Kenji RA Terashima, Masaaki RA Yoshida, Takeshi RA Satoh, Taroh RA Takada, Minoru RA Fukuoka, Masahiro RA Nakagawa, Kazuhiko RT "Differential constitutive activation of the epidermal growth factor RT receptor in non-small cell lung cancer cells bearing EGFR gene RT mutation and amplification."; RL Cancer Res. 67:2046-2053(2007). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=2386953; RA Gazdar, Adi F. RA Linnoila, Ritva Ilona RA Kurita, Yukio RA Oie, Herbert Kazuto RA Mulshine, James L. RA Clark, Jean C. RA Whitsett, Jeffrey A. RT "Peripheral airway cell differentiation in human lung cancer cell RT lines."; RL Cancer Res. 50:5481-5487(1990). // RX PubMed=8956792; DOI=10.1038/bjc.1996.629; PMCID=PMC2077222; RA Fang, Kang RT "An enhanced and sensitive autocrine stimulation by transforming RT growth factor-alpha is acquired in the brain metastatic variant of a RT human non-small-cell lung cancer cell line."; RL Br. J. Cancer 74:1776-1782(1996). // RX PubMed=18083107; DOI=10.1016/j.cell.2007.11.025; RA Rikova, Klarisa RA Guo, Ai-Lan RA Zeng, Qing-Fu RA Possemato, Anthony RA Yu, Jian RA Haack, Herbert RA Nardone, Julie RA Lee, Kimberly RA Reeves, Cynthia RA Li, Yu RA Hu, Ye-Rong RA Tan, Zhi-Ping RA Stokes, Matthew P. RA Sullivan, Laura RA Mitchell, Jeffrey RA Wetzel, Randy RA MacNeill, Joan RA Ren, Jian-Min RA Yuan, Jin RA Bakalarski, Corey E. RA Villen, Judit RA Kornhauser, Jon M. RA Smith, Bradley RA Li, Dai-Qiang RA Zhou, Xin-Min RA Gygi, Steven P. RA Gu, Ting-Lei RA Polakiewicz, Roberto D. RA Rush, John RA Comb, Michael J. RT "Global survey of phosphotyrosine signaling identifies oncogenic RT kinases in lung cancer."; RL Cell 131:1190-1203(2007). // RX PubMed=11030152; DOI=10.1038/sj.onc.1203815; RA Modi, Sanjay RA Kubo, Akihito RA Oie, Herbert Kazuto RA Coxon, Amy B. RA Rehmatulla, Ahad RA Kaye, Frederic J. RT "Protein expression of the RB-related gene family and SV40 large T RT antigen in mesothelioma and lung cancer."; RL Oncogene 19:4632-4639(2000). // RX PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961; RA Abaan, Ogan Demir RA Polley, Eric C. RA Davis, Sean R. RA Zhu, Yue-Lin J. RA Bilke, Sven RA Walker, Robert L. RA Pineda, Marbin A. RA Gindin, Yevgeniy RA Jiang, Yuan RA Reinhold, William C. RA Holbeck, Susan L. RA Simon, Richard M. RA Doroshow, James H. RA Pommier, Yves RA Meltzer, Paul S. RT "The exomes of the NCI-60 panel: a genomic resource for cancer biology RT and systems pharmacology."; RL Cancer Res. 73:4372-4382(2013). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa, Reika RA Kohno, Takashi RA Enari, Masatoshi RA Kiyono, Tohru RA Yokota, Jun RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742; RA Adams, Sharon RA Robbins, Fu-Meei RA Chen, Deborah RA Wagage, Devika RA Holbeck, Susan L. RA Morse, Herbert Carpenter 3rd RA Stroncek, David RA Marincola, Francesco M. RT "HLA class I and II genotype of the NCI-60 cell lines."; RL J. Transl. Med. 3:11.1-11.8(2005). // RX PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356; RA Lorenzi, Philip L. RA Reinhold, William C. RA Varma, Sudhir RA Hutchinson, Amy A. RA Pommier, Yves RA Chanock, Stephen Jacob RA Weinstein, John N. RT "DNA fingerprinting of the NCI-60 cell line panel."; RL Mol. Cancer Ther. 8:713-724(2009). // RX PubMed=1311061; RA Mitsudomi, Tetsuya RA Steinberg, Seth M. RA Nau, Marion M. RA Carbone, David P. RA D'Amico, Domenico RA Bodner, Sara M. RA Oie, Herbert Kazuto RA Linnoila, Ritva Ilona RA Mulshine, James L. RA Minna, John D. RA Gazdar, Adi F. RT "p53 gene mutations in non-small-cell lung cancer cell lines and their RT correlation with the presence of ras mutations and clinical RT features."; RL Oncogene 7:171-180(1992). // RX PubMed=16187286; DOI=10.1002/ijc.21491; RA Garnis, Cathie RA Lockwood, William W. RA Vucic, Emily RA Ge, Ying RA Girard, Luc RA Minna, John D. RA Gazdar, Adi F. RA Lam, Stephen RA MacAulay, Calum RA Lam, Wan L. RT "High resolution analysis of non-small cell lung cancer cell lines by RT whole genome tiling path array CGH."; RL Int. J. Cancer 118:1556-1564(2006). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=8806101; DOI=10.1002/jcb.240630514; RA Lokshin, Anna E. RA Levitt, Mark L. RT "Effect of suramin on squamous differentiation and apoptosis in three RT human non-small-cell lung cancer cell lines."; RL J. Cell. Biochem. Suppl. 24:186-197(1996). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers, Lauren Averett RA Wang, Jing RA Nilsson, Monique B. RA Fujimoto, Junya RA Saintigny, Pierre RA Yordy, John Stuart RA Giri, Uma RA Peyton, Michael RA Fan, You-Hong RA Diao, Li-Xia RA Masrorpour, Fatemeh RA Shen, Li RA Liu, Wen-Bin RA Duchemann, Boris RA Tumula, Praveen RA Bhardwaj, Vikas RA Welsh, James RA Weber, Stephanie RA Glisson, Bonnie S. RA Kalhor, Neda RA Wistuba, Ignacio Ivan RA Girard, Luc RA Lippman, Scott M. RA Mills, Gordon B. RA Coombes, Kevin Robert RA Weinstein, John N. RA Minna, John D. RA Heymach, John Victor RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=17458138; RA Zhang, Hao RA Li, Na RA Chen, Yue RA Huang, Ling-Yun RA Wang, Yi-Ching RA Fang, Gang RA He, Da-Cheng RA Xiao, Xue-Yuan RT "Protein profile of human lung squamous carcinoma cell line RT NCI-H226."; RL Biomed. Environ. Sci. 20:24-32(2007). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=3335022; RA Alley, Michael C. RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121; RA Zampella, John G. RA Rodic, Nemanja RA Yang, Wan Rou RA Huang, Cheng Ran Lisa RA Welch, Jane RA Gnanakkan, Veena P. RA Cornish, Toby Charles RA Boeke, Jef D. RA Burns, Kathleen H. RT "A map of mobile DNA insertions in the NCI-60 human cancer cell RT panel."; RL Mob. DNA 7:20.1-20.11(2016). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin K. RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=2041050; DOI=10.1093/jnci/83.11.757; RA Monks, Anne RA Scudiero, Dominic A. RA Skehan, Philip RA Shoemaker, Robert H. RA Paull, Kenneth D. RA Vistica, David T. RA Hose, Curtis D. RA Langley, John RA Cronise, Paul RA Vaigro-Wolff, Anne RA Gray-Goodrich, Marcia RA Campbell, Hugh RA Mayo, Joseph G. RA Boyd, Michael R. RT "Feasibility of a high-flux anticancer drug screen using a diverse RT panel of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 83:757-766(1991). // RX PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108; RA Gillet, Jean-Pierre RA Calcagno, Anna Maria RA Varma, Sudhir RA Marino, Miguel RA Green, Lisa J. RA Vora, Meena I. RA Patel, Chirayu RA Orina, Josiah N. RA Eliseeva, Tatiana A. RA Singal, Vineet RA Padmanabhan, Raji RA Davidson, Ben RA Ganapathi, Ram RA Sood, Anil K. RA Rueda, Bo R. RA Ambudkar, Suresh V. RA Gottesman, Michael Marc RT "Redefining the relevance of established cancer cell lines to the RT study of mechanisms of clinical anti-cancer drug resistance."; RL Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011). // RX PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189; RA Jain, Mohit RA Nilsson, Roland RA Sharma, Sonia RA Madhusudhan, Nikhil RA Kitami, Toshimori RA Souza, Amanda L. RA Kafri, Ran RA Kirschner, Marc Wallace RA Clish, Clary B. RA Mootha, Vamsi Krishna RT "Metabolite profiling identifies a key role for glycine in rapid RT cancer cell proliferation."; RL Science 336:1040-1044(2012). // RX PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206; RA Dolfi, Sonia C. RA Chan, Leo Li-Ying RA Qiu, Jean RA Tedeschi, Philip M. RA Bertino, Joseph Rocco RA Hirshfield, Kim Marie RA Oltvai, Zoltan Nagy RA Vazquez, Alexei RT "The metabolic demands of cancer cells are coupled to their size and RT protein synthesis rates."; RL Cancer Metab. 1:20.1-20.13(2013). // RX PubMed=29718670; DOI=10.1021/acs.jproteome.8b00165; PMCID=PMC6670293; RA Clark, David J. RA Hu, Ying-Wei RA Bocik, William RA Chen, Li-Jun RA Schnaubelt, Michael RA Roberts, Rhonda R. RA Shah, Punit RA Whiteley, Gordon R. RA Zhang, Hui RT "Evaluation of NCI-7 cell line panel as a reference material for RT clinical proteomics."; RL J. Proteome Res. 17:2205-2215(2018). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=9331090; RA O'Connor, Patrick M. RA Jackman, Joany RA Bae, Insoo RA Myers, Timothy Gene RA Fan, Sai-Jun RA Mutoh, Masato RA Scudiero, Dominic A. RA Monks, Anne RA Sausville, Edward A. RA Weinstein, John N. RA Friend, Stephen H. RA Fornace, Albert J. Jr. RA Kohn, Kurt W. RT "Characterization of the p53 tumor suppressor pathway in cell lines of RT the National Cancer Institute anticancer drug screen and correlations RT with the growth-inhibitory potency of 123 anticancer agents."; RL Cancer Res. 57:4285-4300(1997). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976; RA Wu, D. RA Pang, Yi RA Wilkerson, Matthew D. RA Wang, D. RA Hammerman, Peter S. RA Liu, Jun S. RT "Gene-expression data integration to squamous cell lung cancer RT subtypes reveals drug sensitivity."; RL Br. J. Cancer 109:1599-1608(2013). // RX PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540; RA McMillan, Elizabeth A. RA Ryu, Myung-Jeom RA Diep, Caroline H. RA Mendiratta, Saurabh RA Clemenceau, Jean Rene RA Vaden, Rachel M. RA Kim, Ju-Hwa RA Motoyaji, Takashi RA Covington, Kyle R. RA Peyton, Michael RA Huffman, Kenneth RA Wu, Xiao-Feng RA Girard, Luc RA Sung, Yeojin RA Chen, Pei-Hsaun RA Mallipeddi, Prema Latha RA Lee, Joo Young RA Hanson, Jordan RA Voruganti, Sukesh RA Yu, Yunku RA Park, Sunho RA Sudderth, Jessica RA DeSevo, Christopher RA Muzny, Donna M. RA Doddapaneni, HarshaVardhan RA Gazdar, Adi F. RA Gibbs, Richard Alexander RA Hwang, Tae Hyun RA Heymach, John Victor RA Wistuba, Ignacio Ivan RA Coombes, Kevin Robert RA Williams, Noelle S. RA Wheeler, David A. RA MacMillan, John B. RA DeBerardinis, Ralph J. RA Roth, Michael G. RA Posner, Bruce Arthur RA Minna, John D. RA Kim, Hyun Seok RA White, Michael A. RT "Chemistry-first approach for nomination of personalized treatment in RT lung cancer."; RL Cell 173:864-878.e29(2018). // RX PubMed=1568228; RA Metcalf, Robert A. RA Welsh, Judith A. RA Bennett, William P. RA Seddon, Michael B. RA Lehman, Teresa A. RA Pelin-Enlund, Katarina RA Linnainmaa, Kaija RA Tammilehto, Lauri RA Mattson, Karin RA Gerwin, Brenda Isen RA Harris, Curtis Craig RT "p53 and Kirsten-ras mutations in human mesothelioma cell lines."; RL Cancer Res. 52:2610-2615(1992). // RX PubMed=9488600; DOI=10.1007/s002800050744; RA Ma, Jian-Guo RA Maliepaard, Marc RA Nooter, Kees RA Boersma, Antonius W.M. RA Verweij, Jaap RA Stoter, Gerrit RA Schellens, Jan H.M. RT "Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a RT panel of eight solid-tumor cell lines in vitro."; RL Cancer Chemother. Pharmacol. 41:307-316(1998). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=10700174; DOI=10.1038/73432; RA Ross, Douglas T. RA Scherf, Uwe RA Eisen, Michael Bruce RA Perou, Charles M. RA Rees, Christian RA Spellman, Paul T. RA Iyer, Vishwanath R. RA Jeffrey, Stefanie S. RA van de Rijn, Matt RA Waltham, Mark C. RA Pergamenschikov, Alexander RA Lee, Jeffrey C.F. RA Lashkari, Deval RA Shalon, Dari RA Myers, Timothy Gene RA Weinstein, John N. RA Botstein, David RA Brown, Patrick O'Reilly RT "Systematic variation in gene expression patterns in human cancer cell RT lines."; RL Nat. Genet. 24:227-235(2000). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, A. Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel C. RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=11369051; DOI=10.1016/S0165-4608(00)00363-0; RA Luk, Catherine RA Tsao, Ming-Sound RA Bayani, Jane RA Shepherd, Frances Alice RA Squire, Jeremy Andrew RT "Molecular cytogenetic analysis of non-small cell lung carcinoma by RT spectral karyotyping and comparative genomic hybridization."; RL Cancer Genet. Cytogenet. 125:87-99(2001). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018; RA Moghaddas Gholami, Amin RA Hahne, Hannes RA Wu, Zhi-Xiang RA Auer, Florian Johann RA Meng, Chen RA Wilhelm, Mathias RA Kuster, Bernhard RT "Global proteome analysis of the NCI-60 cell line panel."; RL Cell Rep. 4:609-620(2013). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco, Raquel RA Iwakawa, Reika RA Tang, Mo-Ying RA Kohno, Takashi RA Angulo, Barbara RA Pio, Ruben RA Montuenga, Luis M. RA Minna, John D. RA Yokota, Jun RA Sanchez-Cespedes, Montse RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong, De-Xin RA Yamori, Takao RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511; RA Ruan, Xiao-Yang RA Kocher, Jean-Pierre A. RA Pommier, Yves RA Liu, Hong-Fang RA Reinhold, William C. RT "Mass homozygotes accumulation in the NCI-60 cancer cell lines as RT compared to HapMap trios, and relation to fragile site location."; RL PLoS ONE 7:e31628.1-e31628.9(2012). // RX PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194; RA Kunkel, Mark W. RA Coussens, Nathan P. RA Morris, Joel RA Taylor, Ronald C. RA Dexheimer, Thomas S. RA Jones, Eric M. RA Doroshow, James H. RA Teicher, Beverly A. RT "HTS384 NCI60: the next phase of the NCI60 screen."; RL Cancer Res. 84:2403-2416(2024). // RX PubMed=6272398; DOI=10.1126/science.6272398; RA Moody, Terry W. RA Pert, Candace Beebe RA Gazdar, Adi F. RA Carney, Desmond Niall RA Minna, John D. RT "High levels of intracellular bombesin characterize human small-cell RT lung carcinoma."; RL Science 214:1246-1248(1981). // RX PubMed=9649128; DOI=10.1038/bjc.1998.361; PMCID=PMC2150402; RA Yi, Seung RA Chen, Jing-Ru RA Viallet, Jean RA Schwall, Ralph H. RA Nakamura, T. RA Tsao, Ming-Sound RT "Paracrine effects of hepatocyte growth factor/scatter factor on RT non-small-cell lung carcinoma cell lines."; RL Br. J. Cancer 77:2162-2170(1998). // RX PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877; RA Mestdagh, Pieter RA Lefever, Steve RA Volders, Pieter-Jan RA Derveaux, Stefaan RA Hellemans, Jan RA Vandesompele, Jo RT "Long non-coding RNA expression profiling in the NCI60 cancer cell RT line panel using high-throughput RT-qPCR."; RL Sci. Data 3:160052.1-160052.6(2016). // RX PubMed=25902174; DOI=10.1097/JTO.0000000000000493; RA Miyanaga, Akihiko RA Masuda, Mari RA Tsuta, Koji RA Kawasaki, Kumiko RA Nakamura, Yuka RA Sakuma, Tomohiro RA Asamura, Hisao RA Gemma, Akihiko RA Yamada, Tesshi RT "Hippo pathway gene mutations in malignant mesothelioma: revealed by RT RNA and targeted exon sequencing."; RL J. Thorac. Oncol. 10:844-851(2015). // RX PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665; RA Lee, Jun-Seok RA Kim, Yun Kyung RA Kim, Han Jo RA Hajar, Siti RA Tan, Yee Ling RA Kang, Nam-Young RA Ng, Shin Hui RA Yoon, Chang No RA Chang, Young-Tae RT "Identification of cancer cell-line origins using fluorescence RT image-based phenomic screening."; RL PLoS ONE 7:e32096.1-e32096.8(2012). //