ID NCI-H2126 AC CVCL_1532 SY H2126; H-2126; NCIH2126 DR BTO; BTO_0003240 DR CLO; CLO_0008056 DR EFO; EFO_0002280 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CCL-256 DR ATCC; CRL-5925 DR BioGRID_ORCS_Cell_line; 530 DR BioSample; SAMN03471320 DR BioSample; SAMN03471386 DR BioSample; SAMN05292434 DR BioSample; SAMN10988437 DR cancercelllines; CVCL_1532 DR CCRID; 3101HUMSCSP599 DR Cell_Model_Passport; SIDM00775 DR ChEMBL-Cells; CHEMBL3308894 DR ChEMBL-Targets; CHEMBL2366160 DR CLS; 300639 DR Cosmic; 687814 DR Cosmic; 877266 DR Cosmic; 903616 DR Cosmic; 961841 DR Cosmic; 1006537 DR Cosmic; 1146903 DR Cosmic; 1219066 DR Cosmic; 1239892 DR Cosmic; 1995560 DR Cosmic; 2125182 DR Cosmic; 2629443 DR Cosmic-CLP; 687814 DR DepMap; ACH-000785 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 687814 DR GEO; GSM108839 DR GEO; GSM108840 DR GEO; GSM206485 DR GEO; GSM253405 DR GEO; GSM274811 DR GEO; GSM274812 DR GEO; GSM353228 DR GEO; GSM434271 DR GEO; GSM513958 DR GEO; GSM514343 DR GEO; GSM784235 DR GEO; GSM794354 DR GEO; GSM887408 DR GEO; GSM888487 DR GEO; GSM1374724 DR GEO; GSM1670218 DR IARC_TP53; 21557 DR IGRhCellID; NCIH2126 DR LiGeA; CCLE_835 DR LINCS_LDP; LCL-1627 DR PharmacoDB; NCIH2126_1071_2019 DR PRIDE; PXD002556 DR Progenetix; CVCL_1532 DR PubChem_Cell_line; CVCL_1532 DR Wikidata; Q54907929 RX PubMed=1311061; RX PubMed=8806092; RX PubMed=9559342; RX PubMed=10987304; RX PubMed=11030152; RX PubMed=11314036; RX PubMed=11416159; RX PubMed=14762065; RX PubMed=16157194; RX PubMed=19153074; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20557307; RX PubMed=22460905; RX PubMed=22961666; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26361996; RX PubMed=26589293; RX PubMed=28196595; RX PubMed=29444439; RX PubMed=29681454; RX PubMed=30038707; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=31978347; WW https://www.synapse.org/#!Synapse:syn31544579 WW https://www.cellosaurus.org/pawefish/LungCellLineDescriptions/NCI-H2126.html WW https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Doubling time: 41.1 hours (PubMed=29681454); ~57 hours (PBCF). CC HLA typing: A*02:05,03:01; B*08:20,15:01; C*01:02,04:01; DQA1*03:02,05:02; DQB1*06:02,06:02; DRB1*15:01,16:08 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Trp764Arg (c.2290T>A); Zygosity=Homozygous (Cosmic-CLP=687814; DepMap=ACH-000785). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu62Ter (c.184G>T); ClinVar=VCV000617472; Zygosity=Homozygous (PubMed=20557307; Cosmic-CLP=687814; DepMap=ACH-000785). CC Omics: Array-based CGH. CC Omics: CNV analysis. CC Omics: Deep exome analysis. CC Omics: Deep proteome analysis. CC Omics: Deep quantitative proteome analysis. CC Omics: DNA methylation analysis. CC Omics: Protein expression by reverse-phase protein arrays. CC Omics: SNP array analysis. CC Omics: Transcriptome analysis by microarray. CC Omics: Transcriptome analysis by RNAseq. CC Genome ancestry: African=1.91%; Native American=0.65%; East Asian, North=3.65%; East Asian, South=0%; South Asian=0%; European, North=58.35%; European, South=35.45% (PubMed=30894373). CC Discontinued: ATCC; CRL-5925; true. CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): ATCC=CCL-256; Cosmic-CLP=687814; PubMed=11416159; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 12,14 ST D16S539: 12 ST D18S51: 14 ST D19S433: 14 ST D21S11: 29 ST D2S1338: 17,19 ST D3S1358: 16 ST D5S818: 11 ST D7S820: 8,9 (ATCC=CCL-256; Cosmic-CLP=687814) ST D7S820: 9 (PubMed=25877200) ST D8S1179: 12 ST FGA: 26 ST Penta D: 10 ST Penta E: 7,10 ST TH01: 7,9.3 ST TPOX: 8 ST vWA: 17 DI NCIt; C4450; Lung large cell carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_2652 ! NCI-BL2126 SX Male AG 65Y CA Cancer cell line DT Created: 04-04-12; Last updated: 19-12-24; Version: 45 // RX PubMed=1311061; RA Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D.P., D'Amico D., RA Bodner S.M., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D., RA Gazdar A.F.; RT "p53 gene mutations in non-small-cell lung cancer cell lines and their RT correlation with the presence of ras mutations and clinical RT features."; RL Oncogene 7:171-180(1992). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., RA McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., RA Carney D.N., Minna J.D., Mulshine J.L.; RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2; RA Virmani A.K., Fong K.M., Kodagoda D.R., McIntire D., Hung J.Y., Tonk V., RA Minna J.D., Gazdar A.F.; RT "Allelotyping demonstrates common and distinct patterns of chromosomal RT loss in human lung cancer types."; RL Genes Chromosomes Cancer 21:308-319(1998). // RX PubMed=10987304; RA Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.; RT "Genome-wide allelotyping of lung cancer identifies new regions of RT allelic loss, differences between small cell lung cancer and non-small RT cell lung cancer, and loci clustering."; RL Cancer Res. 60:4894-4906(2000). // RX PubMed=11030152; DOI=10.1038/sj.onc.1203815; RA Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.; RT "Protein expression of the RB-related gene family and SV40 large T RT antigen in mesothelioma and lung cancer."; RL Oncogene 19:4632-4639(2000). // RX PubMed=11314036; DOI=10.1038/sj.onc.1204211; RA Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., RA Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., RA Minna J.D.; RT "Searching for microsatellite mutations in coding regions in lung, RT breast, ovarian and colorectal cancers."; RL Oncogene 20:1005-1009(2001). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., RA Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., RA Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.; RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=14762065; DOI=10.1101/gr.2012304; PMCID=PMC327104; RA Bignell G.R., Huang J., Greshock J., Watt S., Butler A.P., West S., RA Grigorova M., Jones K.W., Wei W., Stratton M.R., Futreal P.A., RA Weber B., Shapero M.H., Wooster R.; RT "High-resolution analysis of DNA copy number using oligonucleotide RT microarrays."; RL Genome Res. 14:287-295(2004). // RX PubMed=16157194; DOI=10.1016/j.cancergencyto.2005.03.007; RA Grigorova M., Lyman R.C., Caldas C., Edwards P.A.W.; RT "Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H RT series analyzed with spectral karyotyping."; RL Cancer Genet. Cytogenet. 162:1-9(2005). // RX PubMed=19153074; DOI=10.1093/hmg/ddp034; RA Medina P.P., Castillo S.D., Blanco S., Sanz-Garcia M., Largo C., RA Alvarez S., Yokota J., Gonzalez-Neira A., Benitez J., Clevers H.C., RA Cigudosa J.C., Lazo P.A., Sanchez-Cespedes M.; RT "The SRY-HMG box gene, SOX4, is a target of gene amplification at RT chromosome 6p in lung cancer."; RL Hum. Mol. Genet. 18:1343-1352(2009). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., RA Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.; RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., RA Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., RA Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., RA Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.; RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., RA Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., RA Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., RA Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., RA Haber D.A.; RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.; RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., RA Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., RA Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., RA Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., RA Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., RA Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., RA Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., RA Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., RA Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., RA Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., RA Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.; RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., RA Yordy J.S., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., RA Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., RA Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., RA Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., RA Heymach J.V.; RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., RA Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., RA Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., RA Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., RA Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., RA Settleman J., Seshagiri S., Zhang Z.-M.; RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., RA Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., RA Neve R.M.; RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003; RA Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., RA Daub H.; RT "Comparative proteome analysis across non-small cell lung cancer cell RT lines."; RL J. Proteomics 130:1-10(2016). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., RA Loewer M., Sahin U., Castle J.C.; RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., RA Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., RA Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., RA Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., RA Liang H.; RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., RA Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D.A., RA Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., RA Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., RA Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., RA McCormick F.; RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). // RX PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540; RA McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., RA Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., RA Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., RA Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., RA DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., RA Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., RA Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., RA Posner B.A., Minna J.D., Kim H.S., White M.A.; RT "Chemistry-first approach for nomination of personalized treatment in RT lung cancer."; RL Cell 173:864-878.e29(2018). // RX PubMed=30038707; DOI=10.18632/oncotarget.25642; PMCID=PMC6049873; RA Du L.-Q., Zhao Z.-Z., Suraokar M.B., Shelton S.S., Ma X.-Y., Hsiao T.-H., RA Minna J.D., Wistuba I.I., Pertsemlidis A.; RT "LMO1 functions as an oncogene by regulating TTK expression and RT correlates with neuroendocrine differentiation of lung cancer."; RL Oncotarget 9:29601-29618(2018). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.; RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., RA McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., RA Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., RA Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., RA Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., RA Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., RA Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., RA Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., RA Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., RA Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., RA Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., RA Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., RA Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., RA Sellers W.R.; RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., RA Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., RA Aldige C.R., Wistuba I.I., Minna J.D.; RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, RA Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., RA Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., RA Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., RA Sellers W.R., Gygi S.P.; RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). //