ID   NCI-H2107
AC   CVCL_1527
SY   H2107; H-2107; NCIH2107
DR   CLO; CLO_0008051
DR   EFO; EFO_0002278
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ATCC; CRL-5983
DR   ATCC; CRL-5983_FL
DR   BioSample; SAMN03472632
DR   cancercelllines; CVCL_1527
DR   ChEMBL-Cells; CHEMBL3308879
DR   ChEMBL-Targets; CHEMBL2366122
DR   Cosmic; 877231
DR   Cosmic; 877386
DR   Cosmic; 924246
DR   Cosmic; 980956
DR   Cosmic; 1021881
DR   Cosmic; 1032427
DR   Cosmic; 1219107
DR   Cosmic; 1239946
DR   Cosmic; 1518091
DR   Cosmic; 1891916
DR   Cosmic; 2125208
DR   GDSC; 924246
DR   GEO; GSM171858
DR   GEO; GSM171859
DR   GEO; GSM794352
DR   GEO; GSM844637
DR   GEO; GSM845544
DR   GEO; GSM1887915
DR   GEO; GSM1887999
DR   IARC_TP53; 27568
DR   IARC_TP53; 28455
DR   IGRhCellID; NCIH2107
DR   PharmacoDB; NCIH2107_1067_2019
DR   PRIDE; PXD011896
DR   Progenetix; CVCL_1527
DR   PubChem_Cell_line; CVCL_1527
DR   Wikidata; Q54907923
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9559342;
RX   PubMed=10987304;
RX   PubMed=11030152;
RX   PubMed=11314036;
RX   PubMed=19472407;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20557307;
RX   PubMed=20624269;
RX   PubMed=22961666;
RX   PubMed=23716474;
RX   PubMed=27247353;
RX   PubMed=28766886;
RX   PubMed=31803961;
RX   PubMed=32586373;
RX   PubMed=39154123;
CC   Population: African American.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys101Ter (c.301A>T); Zygosity=Unspecified (PubMed=20557307).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; CRL-5983; true.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-5983_FL
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 12,13
ST   D16S539: 10,13
ST   D5S818: 14
ST   D7S820: 8
ST   TH01: 6,7
ST   TPOX: 10,11
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2650 ! NCI-BL2107
OI   CVCL_1528 ! NCI-H2108
SX   Male
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 38
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922;
RA   Byers, Lauren Averett
RA   Wang, Jing
RA   Nilsson, Monique B.
RA   Fujimoto, Junya
RA   Saintigny, Pierre
RA   Yordy, John Stuart
RA   Giri, Uma
RA   Peyton, Michael
RA   Fan, You-Hong
RA   Diao, Li-Xia
RA   Masrorpour, Fatemeh
RA   Shen, Li
RA   Liu, Wen-Bin
RA   Duchemann, Boris
RA   Tumula, Praveen
RA   Bhardwaj, Vikas
RA   Welsh, James
RA   Weber, Stephanie
RA   Glisson, Bonnie S.
RA   Kalhor, Neda
RA   Wistuba, Ignacio Ivan
RA   Girard, Luc
RA   Lippman, Scott M.
RA   Mills, Gordon B.
RA   Coombes, Kevin Robert
RA   Weinstein, John N.
RA   Minna, John D.
RA   Heymach, John Victor
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339;
RA   Du, Li-Qin
RA   Schageman, Jeoffrey J.
RA   Irnov, Irnov
RA   Girard, Luc
RA   Hammond, Scott M.
RA   Minna, John D.
RA   Gazdar, Adi F.
RA   Pertsemlidis, Alexander
RT   "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells
RT   and suggests a possible pathological relationship between SCLCs and
RT   NSCLCs.";
RL   J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Fer, Nicole
RA   Sonkin, Dmitriy
RA   Kaur, Gurmeet
RA   Monks, Anne
RA   Malik, Shakun
RA   Morris, Joel
RA   Teicher, Beverly A.
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher, Beverly A.
RA   Silvers, Thomas E.
RA   Selby, Michael
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Parchment, Ralph E.
RA   Krushkal, Julia
RA   Sonkin, Dmitriy
RA   Rubinstein, Lawrence
RA   Morris, Joel
RA   Evans, David
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson, Bruce E.
RA   Russell, Edward
RA   Simmons, Alfreda M.
RA   Phelps, Ruby M.
RA   Steinberg, Seth M.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277;
RA   Iwakawa, Reika
RA   Takenaka, Masataka
RA   Kohno, Takashi
RA   Shimada, Yoko
RA   Totoki, Yasushi
RA   Shibata, Tatsuhiro
RA   Tsuta, Koji
RA   Nishikawa, Ryo
RA   Noguchi, Masayuki
RA   Sato-Otsubo, Aiko
RA   Ogawa, Seishi
RA   Yokota, Jun
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal, Julia
RA   Silvers, Thomas E.
RA   Reinhold, William C.
RA   Sonkin, Dmitriy
RA   Vural, Suleyman
RA   Connelly, John
RA   Varma, Sudhir
RA   Meltzer, Paul S.
RA   Kunkel, Mark W.
RA   Rapisarda, Annamaria
RA   Evans, David
RA   Pommier, Yves
RA   Teicher, Beverly A.
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=39154123; DOI=10.1038/s41388-024-03125-x; PMCID=PMC11405284;
RA   Nguyen, Aiden
RA   Nunez, Clarissa G.
RA   Tran, Tram Anh
RA   Girard, Luc
RA   Peyton, Michael
RA   Catalan, Rodrigo
RA   Guerena, Cristina D.
RA   Avila, Kimberley
RA   Drapkin, Benjamin J.
RA   Chandra, Raghav
RA   Minna, John D.
RA   Martinez, Elisabeth D.
RT   "Jumonji histone demethylases are therapeutic targets in small cell
RT   lung cancer.";
RL   Oncogene 43:2885-2899(2024).
//
RX   PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2;
RA   Virmani, Arvind K.
RA   Fong, Kwun M.
RA   Kodagoda, Dulmini R.
RA   McIntire, Donald
RA   Hung, Jaclyn Y.
RA   Tonk, Vijay
RA   Minna, John D.
RA   Gazdar, Adi F.
RT   "Allelotyping demonstrates common and distinct patterns of chromosomal
RT   loss in human lung cancer types.";
RL   Genes Chromosomes Cancer 21:308-319(1998).
//
RX   PubMed=10987304;
RA   Girard, Luc
RA   Zochbauer-Muller, Sabine
RA   Virmani, Arvind K.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "Genome-wide allelotyping of lung cancer identifies new regions of
RT   allelic loss, differences between small cell lung cancer and non-small
RT   cell lung cancer, and loci clustering.";
RL   Cancer Res. 60:4894-4906(2000).
//