ID   NCI-H2029
AC   CVCL_1516
SY   H2029; H-2029; NCIH2029
DR   BTO; BTO_0005977
DR   CLO; CLO_0008040
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-5913
DR   BioSample; SAMN10987644
DR   cancercelllines; CVCL_1516
DR   Cell_Model_Passport; SIDM00735
DR   ChEMBL-Cells; CHEMBL3308473
DR   ChEMBL-Targets; CHEMBL1075529
DR   Cosmic; 688011
DR   Cosmic; 1995552
DR   Cosmic; 2125207
DR   Cosmic-CLP; 688011
DR   DepMap; ACH-000298
DR   EGA; EGAS00001000978
DR   GDSC; 688011
DR   GEO; GSM887396
DR   GEO; GSM888474
DR   GEO; GSM1670207
DR   GEO; GSM1887957
DR   GEO; GSM1888034
DR   IARC_TP53; 21551
DR   LiGeA; CCLE_738
DR   LINCS_LDP; LCL-1814
DR   PharmacoDB; NCIH2029_1057_2019
DR   PRIDE; PXD011896
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1516
DR   PubChem_Cell_line; CVCL_1516
DR   Wikidata; Q54907905
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=11030152;
RX   PubMed=20164919;
RX   PubMed=20679594;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=27247353;
RX   PubMed=27397505;
RX   PubMed=28766886;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31803961;
RX   PubMed=32586373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   HLA typing: A*02:01,11:01; B*07:02,35:08; C*07:02,07:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; c.265-1G>T; Zygosity=Homozygous; Note=Splice acceptor mutation (Cosmic-CLP=688011; DepMap=ACH-000298).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Asp (c.658T>G); ClinVar=VCV000376689; Zygosity=Homozygous (Cosmic-CLP=688011; DepMap=ACH-000298).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=4.84%; Native American=0%; East Asian, North=5.65%; East Asian, South=0%; South Asian=0%; European, North=50.95%; European, South=38.55% (PubMed=30894373).
CC   Caution: The stock distributed by ATCC seems to have lost the D13S317 allele which is not detectable (ATCC=CRL-5913).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ATCC=CRL-5913; Cosmic-CLP=688011; PubMed=20679594
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,14
ST   D16S539: 12
ST   D18S51: 15
ST   D19S433: 14,15
ST   D21S11: 30,31.2
ST   D2S1338: 17,22
ST   D3S1358: 16,17
ST   D5S818: 10,11
ST   D7S820: 9,11
ST   D8S1179: 11,15
ST   FGA: 21,25
ST   Penta D: 9
ST   Penta E: 9
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 15,19
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1513 ! NCI-H1994
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 41
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474;
RA   Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.;
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J.,
RA   Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N.,
RA   Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.;
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C.,
RA   Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L.,
RA   Morris J., Evans D.;
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal J., Silvers T.E., Reinhold W.C., Sonkin D., Vural S.,
RA   Connelly J., Varma S., Meltzer P.S., Kunkel M.W., Rapisarda A.,
RA   Evans D., Pommier Y., Teicher B.A.;
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//