ID   NCI-H1672
AC   CVCL_1486
SY   H1672; H-1672
DR   BTO; BTO:0005975
DR   CLO; CLO_0008010
DR   ATCC; CRL-5886
DR   BioSample; SAMN03473009
DR   cancercelllines; CVCL_1486
DR   Cosmic; 688005
DR   Cosmic; 852002
DR   Cosmic; 877227
DR   Cosmic; 980952
DR   Cosmic; 1021878
DR   Cosmic; 1032422
DR   Cosmic; 1759264
DR   Cosmic; 1891912
DR   Cosmic; 2125237
DR   GEO; GSM108823
DR   GEO; GSM108824
DR   GEO; GSM794327
DR   IARC_TP53; 431
DR   Wikidata; Q54907844
RX   PubMed=1312696;
RX   PubMed=8183553;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9559342;
RX   PubMed=10987304;
RX   PubMed=11030152;
RX   PubMed=11314036;
RX   PubMed=20624269;
RX   PubMed=22961666;
RX   PubMed=25877200;
RX   PubMed=31803961;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.His61Arg (c.182A>G); ClinVar=VCV000189402; Zygosity=Unspecified (PubMed=22961666).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Val (c.797G>T); ClinVar=VCV000233303; Zygosity=Unspecified (PubMed=1312696).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Gly106Asp (c.317G>A); Zygosity=Unspecified (PubMed=8183553).
CC   Omics: miRNA expression profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ATCC=CRL-5886; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 13,14
ST   D19S433: 15
ST   D21S11: 29,32.2
ST   D2S1338: 21,27
ST   D3S1358: 18
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 11,14
ST   FGA: 21
ST   Penta D: 8,12
ST   Penta E: 9
ST   TH01: 10
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2643 ! NCI-BL1672
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 27
//
RX   PubMed=1312696;
RA   D'Amico D., Carbone D.P., Mitsudomi T., Nau M.M., Fedorko J.,
RA   Russell E., Johnson B., Buchhagen D.L., Bodner S.M., Phelps R.M.,
RA   Gazdar A.F., Minna J.D.;
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
//
RX   PubMed=8183553;
RA   Sekido Y., Bader S.A., Latif F., Gnarra J.R., Gazdar A.F., Linehan W.M.,
RA   Zbar B., Lerman M.I., Minna J.D.;
RT   "Molecular analysis of the von Hippel-Lindau disease tumor suppressor
RT   gene in human lung cancer cell lines.";
RL   Oncogene 9:1599-1604(1994).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
//
RX   PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2;
RA   Virmani A.K., Fong K.M., Kodagoda D.R., McIntire D., Hung J., Tonk V.,
RA   Minna J.D., Gazdar A.F.;
RT   "Allelotyping demonstrates common and distinct patterns of chromosomal
RT   loss in human lung cancer types.";
RL   Genes Chromosomes Cancer 21:308-319(1998).
//
RX   PubMed=10987304;
RA   Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.;
RT   "Genome-wide allelotyping of lung cancer identifies new regions of
RT   allelic loss, differences between small cell lung cancer and non-small
RT   cell lung cancer, and loci clustering.";
RL   Cancer Res. 60:4894-4906(2000).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=20624269; DOI=10.1186/1756-9966-29-75;
RA   Du L.-Q., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D.,
RA   Gazdar A.F., Pertsemlidis A.;
RT   "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells
RT   and suggests a possible pathological relationship between SCLCs and
RT   NSCLCs.";
RL   J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112;
RA   Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P.,
RA   Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F.,
RA   Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J.,
RA   Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L.,
RA   Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D.,
RA   Heymach J.V.;
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//