ID   NCI-H1672
AC   CVCL_1486
SY   H1672; H-1672
DR   BTO; BTO_0005975
DR   CLO; CLO_0008010
DR   ATCC; CRL-5886
DR   BioSample; SAMN03473009
DR   cancercelllines; CVCL_1486
DR   Cosmic; 688005
DR   Cosmic; 852002
DR   Cosmic; 877227
DR   Cosmic; 980952
DR   Cosmic; 1021878
DR   Cosmic; 1032422
DR   Cosmic; 1759264
DR   Cosmic; 1891912
DR   Cosmic; 2125237
DR   GEO; GSM108823
DR   GEO; GSM108824
DR   GEO; GSM794327
DR   GEO; GSM1887943
DR   GEO; GSM1888019
DR   IARC_TP53; 431
DR   Wikidata; Q54907844
RX   PubMed=1312696;
RX   PubMed=8183553;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9559342;
RX   PubMed=10987304;
RX   PubMed=11030152;
RX   PubMed=11314036;
RX   PubMed=20624269;
RX   PubMed=22961666;
RX   PubMed=25877200;
RX   PubMed=27247353;
RX   PubMed=28766886;
RX   PubMed=31803961;
RX   PubMed=32586373;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.His61Arg (c.182A>G); ClinVar=VCV000189402; Zygosity=Unspecified (PubMed=22961666).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Val (c.797G>T); ClinVar=VCV000233303; Zygosity=Unspecified (PubMed=1312696).
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly106Asp (c.317G>A); Zygosity=Unspecified (PubMed=8183553).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ATCC=CRL-5886; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 13,14
ST   D19S433: 15
ST   D21S11: 29,32.2
ST   D2S1338: 21,27
ST   D3S1358: 18
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 11,14
ST   FGA: 21
ST   Penta D: 8,12
ST   Penta E: 9
ST   TH01: 10
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2643 ! NCI-BL1672
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=8183553;
RA   Sekido, Yoshitaka
RA   Bader, Scott A.
RA   Latif, Farida
RA   Gnarra, James R.
RA   Gazdar, Adi F.
RA   Linehan, William Marston
RA   Zbar, Berton
RA   Lerman, Michael I.
RA   Minna, John D.
RT   "Molecular analysis of the von Hippel-Lindau disease tumor suppressor
RT   gene in human lung cancer cell lines.";
RL   Oncogene 9:1599-1604(1994).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922;
RA   Byers, Lauren Averett
RA   Wang, Jing
RA   Nilsson, Monique B.
RA   Fujimoto, Junya
RA   Saintigny, Pierre
RA   Yordy, John Stuart
RA   Giri, Uma
RA   Peyton, Michael
RA   Fan, You-Hong
RA   Diao, Li-Xia
RA   Masrorpour, Fatemeh
RA   Shen, Li
RA   Liu, Wen-Bin
RA   Duchemann, Boris
RA   Tumula, Praveen
RA   Bhardwaj, Vikas
RA   Welsh, James
RA   Weber, Stephanie
RA   Glisson, Bonnie S.
RA   Kalhor, Neda
RA   Wistuba, Ignacio Ivan
RA   Girard, Luc
RA   Lippman, Scott M.
RA   Mills, Gordon B.
RA   Coombes, Kevin Robert
RA   Weinstein, John N.
RA   Minna, John D.
RA   Heymach, John Victor
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339;
RA   Du, Li-Qin
RA   Schageman, Jeoffrey J.
RA   Irnov, Irnov
RA   Girard, Luc
RA   Hammond, Scott M.
RA   Minna, John D.
RA   Gazdar, Adi F.
RA   Pertsemlidis, Alexander
RT   "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells
RT   and suggests a possible pathological relationship between SCLCs and
RT   NSCLCs.";
RL   J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Fer, Nicole
RA   Sonkin, Dmitriy
RA   Kaur, Gurmeet
RA   Monks, Anne
RA   Malik, Shakun
RA   Morris, Joel
RA   Teicher, Beverly A.
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher, Beverly A.
RA   Silvers, Thomas E.
RA   Selby, Michael
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Parchment, Ralph E.
RA   Krushkal, Julia
RA   Sonkin, Dmitriy
RA   Rubinstein, Lawrence
RA   Morris, Joel
RA   Evans, David
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson, Bruce E.
RA   Russell, Edward
RA   Simmons, Alfreda M.
RA   Phelps, Ruby M.
RA   Steinberg, Seth M.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526;
RA   Krushkal, Julia
RA   Silvers, Thomas E.
RA   Reinhold, William C.
RA   Sonkin, Dmitriy
RA   Vural, Suleyman
RA   Connelly, John
RA   Varma, Sudhir
RA   Meltzer, Paul S.
RA   Kunkel, Mark W.
RA   Rapisarda, Annamaria
RA   Evans, David
RA   Pommier, Yves
RA   Teicher, Beverly A.
RT   "Epigenome-wide DNA methylation analysis of small cell lung cancer
RT   cell lines suggests potential chemotherapy targets.";
RL   Clin. Epigenetics 12:93.1-93.28(2020).
//
RX   PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2;
RA   Virmani, Arvind K.
RA   Fong, Kwun M.
RA   Kodagoda, Dulmini R.
RA   McIntire, Donald
RA   Hung, Jaclyn Y.
RA   Tonk, Vijay
RA   Minna, John D.
RA   Gazdar, Adi F.
RT   "Allelotyping demonstrates common and distinct patterns of chromosomal
RT   loss in human lung cancer types.";
RL   Genes Chromosomes Cancer 21:308-319(1998).
//
RX   PubMed=10987304;
RA   Girard, Luc
RA   Zochbauer-Muller, Sabine
RA   Virmani, Arvind K.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "Genome-wide allelotyping of lung cancer identifies new regions of
RT   allelic loss, differences between small cell lung cancer and non-small
RT   cell lung cancer, and loci clustering.";
RL   Cancer Res. 60:4894-4906(2000).
//
RX   PubMed=1312696;
RA   D'Amico, Domenico
RA   Carbone, David P.
RA   Mitsudomi, Tetsuya
RA   Nau, Marion M.
RA   Fedorko, Joseph
RA   Russell, Edward
RA   Johnson, Britt
RA   Buchhagen, Dotothy L.
RA   Bodner, Sara M.
RA   Phelps, Ruby M.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
//