ID NCI-H1573 AC CVCL_1478 SY H1573; H-1573; NCIH1573 DR CLO; CLO_0008002 DR EFO; EFO_0002256 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-5877 DR BioSample; SAMN03472584 DR BioSample; SAMN10987661 DR cancercelllines; CVCL_1478 DR Cell_Model_Passport; SIDM00749 DR ChEMBL-Cells; CHEMBL3308117 DR ChEMBL-Targets; CHEMBL1075515 DR Cosmic; 687796 DR Cosmic; 877243 DR Cosmic; 877425 DR Cosmic; 903595 DR Cosmic; 908472 DR Cosmic; 1995526 DR Cosmic; 2125179 DR Cosmic-CLP; 908472 DR DepMap; ACH-000916 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR GDSC; 908472 DR GEO; GSM794321 DR GEO; GSM827530 DR GEO; GSM887368 DR GEO; GSM888446 DR GEO; GSM1670177 DR IARC_TP53; 496 DR IGRhCellID; NCIH1573 DR KCLB; 91573 DR LiGeA; CCLE_321 DR LINCS_LDP; LCL-1638 DR PharmacoDB; NCIH1573_1023_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1478 DR PubChem_Cell_line; CVCL_1478 DR Wikidata; Q54907825 RX PubMed=1311061; RX PubMed=8806092; RX PubMed=11030152; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=29444439; RX PubMed=29681454; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=31978347; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC HLA typing: A*30:01,30:01; B*14:02,14:02; C*08:02,08:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (Cosmic-CLP=908472; DepMap=ACH-000916). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP=908472; DepMap=ACH-000916). CC Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Arg351Ter (c.1051C>T); ClinVar=VCV000372552; Zygosity=Heterozygous (Cosmic-CLP=908472; DepMap=ACH-000916). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (PubMed=1311061; Cosmic-CLP=908472; DepMap=ACH-000916). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.85%; Native American=0%; East Asian, North=5.57%; East Asian, South=0%; South Asian=0%; European, North=54.36%; European, South=38.22% (PubMed=30894373). CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): ATCC=CRL-5877; Cosmic-CLP=908472 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 11,13 ST D16S539: 12 ST D18S51: 14 ST D19S433: 13 ST D21S11: 29 ST D2S1338: 17,23 ST D3S1358: 17 ST D5S818: 11,13 ST D7S820: 9,11 ST D8S1179: 13,14 ST FGA: 20,22 ST Penta D: 11,13 ST Penta E: 12,15 ST TH01: 6 ST TPOX: 8,11 ST vWA: 17,18 DI NCIt; C3512; Lung adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 35Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 // RX PubMed=1311061; RA Mitsudomi, Tetsuya RA Steinberg, Seth M. RA Nau, Marion M. RA Carbone, David P. RA D'Amico, Domenico RA Bodner, Sara M. RA Oie, Herbert Kazuto RA Linnoila, Ritva Ilona RA Mulshine, James L. RA Minna, John D. RA Gazdar, Adi F. RT "p53 gene mutations in non-small-cell lung cancer cell lines and their RT correlation with the presence of ras mutations and clinical RT features."; RL Oncogene 7:171-180(1992). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=11030152; DOI=10.1038/sj.onc.1203815; RA Modi, Sanjay RA Kubo, Akihito RA Oie, Herbert Kazuto RA Coxon, Amy B. RA Rehmatulla, Ahad RA Kaye, Frederic J. RT "Protein expression of the RB-related gene family and SV40 large T RT antigen in mesothelioma and lung cancer."; RL Oncogene 19:4632-4639(2000). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540; RA McMillan, Elizabeth A. RA Ryu, Myung-Jeom RA Diep, Caroline H. RA Mendiratta, Saurabh RA Clemenceau, Jean Rene RA Vaden, Rachel M. RA Kim, Ju-Hwa RA Motoyaji, Takashi RA Covington, Kyle R. RA Peyton, Michael RA Huffman, Kenneth RA Wu, Xiao-Feng RA Girard, Luc RA Sung, Yeojin RA Chen, Pei-Hsaun RA Mallipeddi, Prema Latha RA Lee, Joo Young RA Hanson, Jordan RA Voruganti, Sukesh RA Yu, Yunku RA Park, Sunho RA Sudderth, Jessica RA DeSevo, Christopher RA Muzny, Donna M. RA Doddapaneni, HarshaVardhan RA Gazdar, Adi F. RA Gibbs, Richard Alexander RA Hwang, Tae Hyun RA Heymach, John Victor RA Wistuba, Ignacio Ivan RA Coombes, Kevin Robert RA Williams, Noelle S. RA Wheeler, David A. RA MacMillan, John B. RA DeBerardinis, Ralph J. RA Roth, Michael G. RA Posner, Bruce Arthur RA Minna, John D. RA Kim, Hyun Seok RA White, Michael A. RT "Chemistry-first approach for nomination of personalized treatment in RT lung cancer."; RL Cell 173:864-878.e29(2018). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan, Tina L. RA Amzallag, Arnaud RA Bagni, Rachel RA Yi, Ming RA Afghani, Shervin RA Burgan, William RA Fer, Nicole RA Strathern, Leslie A. RA Powell, Katie RA Smith, Brian RA Waters, Andrew Michael RA Drubin, David Alan RA Thomson, Ty RA Liao, Rosy RA Greninger, Patricia RA Stein, Giovanna T. RA Murchie, Ellen RA Cortez, Eliane RA Egan, Regina K. RA Procter, Lauren RA Bess, Matthew RA Cheng, Kwong Tai RA Lee, Chih-Shia RA Lee, Liam Changwoo RA Fellmann, Christof RA Stephens, Robert RA Luo, Ji RA Lowe, Scott William RA Benes, Cyril Henri RA McCormick, Frank RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). //