ID   NCI-H1385
AC   CVCL_1466
SY   H1385; H-1385; NCIH1385
DR   CLO; CLO_0007991
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-5867
DR   BioSample; SAMN03472581
DR   BioSample; SAMN10988439
DR   cancercelllines; CVCL_1466
DR   Cell_Model_Passport; SIDM01676
DR   Cosmic; 687793
DR   Cosmic; 722041
DR   Cosmic; 877420
DR   Cosmic; 903589
DR   Cosmic; 930489
DR   Cosmic; 980974
DR   Cosmic; 1032446
DR   Cosmic; 1219081
DR   Cosmic; 1891889
DR   Cosmic; 2125228
DR   DepMap; ACH-000737
DR   FANTOM5_SSTAR; 10730-110B1
DR   GDSC; 1330965
DR   GEO; GSM794314
DR   GEO; GSM887360
DR   GEO; GSM888438
DR   IARC_TP53; 30128
DR   KCLB; 91385
DR   LiGeA; CCLE_839
DR   LINCS_LDP; LCL-1624
DR   PharmacoDB; NCIH1385_1012_2019
DR   Progenetix; CVCL_1466
DR   Wikidata; Q54907799
RX   PubMed=1311061;
RX   PubMed=8626706;
RX   PubMed=8806092;
RX   PubMed=11030152;
RX   PubMed=22460905;
RX   PubMed=24002593;
RX   PubMed=26589293;
RX   PubMed=28196595;
RX   PubMed=29681454;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31803961;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Population: African American.
CC   HLA typing: A*03:01,34:02; B*58:02,58:02; C*06:02,06:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (DepMap=ACH-000737).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=69.29%; Native American=0%; East Asian, North=3.93%; East Asian, South=0%; South Asian=0%; European, North=10.32%; European, South=16.46% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ATCC=CRL-5867; KCLB=91385
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 9,11
ST   D18S51: 14,17
ST   D19S433: 11.2,13
ST   D21S11: 30
ST   D2S1338: 20,23
ST   D3S1358: 14,18
ST   D5S818: 13
ST   D7S820: 8,10
ST   D8S1179: 14,16
ST   FGA: 24
ST   Penta D: 8
ST   Penta E: 7,12
ST   TH01: 7
ST   TPOX: 8,9
ST   vWA: 17,19
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   49Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=1311061;
RA   Mitsudomi, Tetsuya
RA   Steinberg, Seth M.
RA   Nau, Marion M.
RA   Carbone, David P.
RA   D'Amico, Domenico
RA   Bodner, Sara M.
RA   Oie, Herbert Kazuto
RA   Linnoila, Ritva Ilona
RA   Mulshine, James L.
RA   Minna, John D.
RA   Gazdar, Adi F.
RT   "p53 gene mutations in non-small-cell lung cancer cell lines and their
RT   correlation with the presence of ras mutations and clinical
RT   features.";
RL   Oncogene 7:171-180(1992).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976;
RA   Wu, Di
RA   Pang, Yi
RA   Wilkerson, Matthew D.
RA   Wang, Die
RA   Hammerman, Peter S.
RA   Liu, Jun S.
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540;
RA   McMillan, Elizabeth A.
RA   Ryu, Myung-Jeom
RA   Diep, Caroline H.
RA   Mendiratta, Saurabh
RA   Clemenceau, Jean Rene
RA   Vaden, Rachel M.
RA   Kim, Ju-Hwa
RA   Motoyaji, Takashi
RA   Covington, Kyle R.
RA   Peyton, Michael
RA   Huffman, Kenneth
RA   Wu, Xiao-Feng
RA   Girard, Luc
RA   Sung, Yeojin
RA   Chen, Pei-Hsaun
RA   Mallipeddi, Prema Latha
RA   Lee, Joo Young
RA   Hanson, Jordan
RA   Voruganti, Sukesh
RA   Yu, Yunku
RA   Park, Sunho
RA   Sudderth, Jessica
RA   DeSevo, Christopher
RA   Muzny, Donna M.
RA   Doddapaneni, HarshaVardhan
RA   Gazdar, Adi F.
RA   Gibbs, Richard Alexander
RA   Hwang, Tae Hyun
RA   Heymach, John Victor
RA   Wistuba, Ignacio Ivan
RA   Coombes, Kevin Robert
RA   Williams, Noelle S.
RA   Wheeler, David A.
RA   MacMillan, John B.
RA   DeBerardinis, Ralph J.
RA   Roth, Michael G.
RA   Posner, Bruce Arthur
RA   Minna, John D.
RA   Kim, Hyun Seok
RA   White, Michael A.
RT   "Chemistry-first approach for nomination of personalized treatment in
RT   lung cancer.";
RL   Cell 173:864-878.e29(2018).
//
RX   PubMed=8626706; DOI=10.1074/jbc.271.19.11477;
RA   Quinn, Kathryn A.
RA   Treston, Anthony M.
RA   Unsworth, Edward J.
RA   Miller, Mae-Jean
RA   Vos, Michele
RA   Grimley, Chris
RA   Battey, James
RA   Mulshine, James L.
RA   Cuttitta, Frank
RT   "Insulin-like growth factor expression in human cancer cell lines.";
RL   J. Biol. Chem. 271:11477-11483(1996).
//