ID   ML-2
AC   CVCL_1418
SY   ML2
DR   BTO; BTO_0001885
DR   CLO; CLO_0007736
DR   EFO; EFO_0002238
DR   CLDB; cl3490
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472168
DR   cancercelllines; CVCL_1418
DR   Cell_Model_Passport; SIDM00441
DR   ChEMBL-Cells; CHEMBL3307604
DR   ChEMBL-Targets; CHEMBL614356
DR   Cosmic; 787454
DR   Cosmic; 850389
DR   Cosmic; 908141
DR   Cosmic; 975271
DR   Cosmic; 999728
DR   Cosmic; 1012092
DR   Cosmic; 1078727
DR   Cosmic; 1078739
DR   Cosmic; 1151785
DR   Cosmic; 1181602
DR   Cosmic; 1281329
DR   Cosmic; 1524834
DR   Cosmic; 2131545
DR   Cosmic; 2391904
DR   Cosmic; 2750863
DR   Cosmic-CLP; 908141
DR   DepMap; ACH-002273
DR   DSMZ; ACC-15
DR   DSMZCellDive; ACC-15
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 908141
DR   GEO; GSM236791
DR   GEO; GSM236827
DR   GEO; GSM482497
DR   GEO; GSM1374683
DR   GEO; GSM1446737
DR   GEO; GSM1670116
DR   IGRhCellID; ML2
DR   LINCS_LDP; LCL-1060
DR   PharmacoDB; ML2_942_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1418
DR   PubChem_Cell_line; CVCL_1418
DR   Wikidata; Q54905843
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3458526;
RX   PubMed=3874327;
RX   PubMed=6091813;
RX   PubMed=14671638;
RX   PubMed=15843827;
RX   PubMed=16408098;
RX   PubMed=16969076;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~60 hours (DSMZ=ACC-15).
CC   HLA typing: A*02:01,02:01; B*44:02,51:01; C*05:01,14:02; DRB1*14:103,14:103 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7137; AFDN + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFDN, MLL-MLLT4, MLL-AF6 (PubMed=14671638; PubMed=25485619).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Heterozygous (PubMed=16969076; Cosmic-CLP=908141; DepMap=ACH-002273).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=0%; East Asian, South=0%; South Asian=0.26%; European, North=70.54%; European, South=29.2% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): Cosmic-CLP=908141; DSMZ=ACC-15; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 9,12
ST   D18S51: 15,18
ST   D19S433: 14
ST   D21S11: 29
ST   D2S1338: 16,17
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 9,11
ST   D8S1179: 8,13
ST   FGA: 23,25
ST   Penta D: 12
ST   Penta E: 5,7
ST   TH01: 7,9.3
ST   TPOX: 8,10
ST   vWA: 16
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   NCIt; C132105; Acute myeloid leukemia with t(6;11)(q27;q23) KMT2A-MLLT4
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0436 ! ML-1 [Human leukemia]
OI   CVCL_H526 ! ML-3
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 44
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier, Hilmar
RA   MacLeod, Roderick A.F.
RA   Zaborski, Margarete
RA   Drexler, Hans Gunther
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler, Hans Gunther
RA   Quentmeier, Hilmar
RA   MacLeod, Roderick A.F.
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=3458526;
RA   Ohyashiki, Kazuma
RA   Ohyashiki, Junko H.
RA   Sandberg, Avery Aba
RT   "Cytogenetic characterization of putative human myeloblastic leukemia
RT   cell lines (ML-1, -2, and -3): origin of the cells.";
RL   Cancer Res. 46:3642-3647(1986).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059;
RA   Palumbo, Antonio
RA   Minowada, Jun
RA   Erikson, Jan
RA   Croce, Carlo Maria
RA   Rovera, Giovanni
RT   "Lineage infidelity of a human myelogenous leukemia cell line.";
RL   Blood 64:1059-1063(1984).
//
RX   PubMed=16969076; DOI=10.4161/cbt.5.8.3251; PMCID=PMC2714972;
RA   Edkins, Sarah
RA   O'Meara, Sarah
RA   Parker, Adrian
RA   Stevens, Claire
RA   Reis, Marcelo
RA   Jones, Sian
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Dalgliesh, Gillian L.
RA   Forbes, Simon
RA   Hunter, Chris
RA   Smith, Raffaella
RA   Stephens, Philip J.
RA   Goldstraw, Peter
RA   Nicholson, Andrew
RA   Chan, Tsun-Leung
RA   Velculescu, Victor E.
RA   Yuen, Siu Tsan
RA   Leung, Suet Yi
RA   Stratton, Michael Rudolf
RA   Futreal, P. Andrew
RT   "Recurrent KRAS codon 146 mutations in human colorectal cancer.";
RL   Cancer Biol. Ther. 5:928-932(2006).
//