ID MKN7 AC CVCL_1417 SY MKN-7; MKN 7 DR BTO; BTO_0002382 DR CLO; CLO_0050805 DR EFO; EFO_0002895 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03472197 DR BioSample; SAMN03473201 DR BioSample; SAMN10988431 DR cancercelllines; CVCL_1417 DR Cell_Model_Passport; SIDM00560 DR CGH-DB; 118-1 DR CGH-DB; 9020-4 DR ChEMBL-Cells; CHEMBL3307377 DR ChEMBL-Targets; CHEMBL614355 DR CLS; 305104 DR Cosmic; 733175 DR Cosmic; 848370 DR Cosmic; 877040 DR Cosmic; 888825 DR Cosmic; 889106 DR Cosmic; 897533 DR Cosmic; 922693 DR Cosmic; 924250 DR Cosmic; 926112 DR Cosmic; 968347 DR Cosmic; 983725 DR Cosmic; 1007601 DR Cosmic; 1066229 DR Cosmic; 1093297 DR Cosmic; 1187284 DR Cosmic; 1223587 DR Cosmic; 1436024 DR Cosmic; 1460708 DR Cosmic; 1482077 DR Cosmic; 1518242 DR Cosmic; 1995511 DR Cosmic; 2807634 DR Cosmic-CLP; 924250 DR DepMap; ACH-000678 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 924250 DR GEO; GSM552365 DR GEO; GSM562401 DR GEO; GSM827584 DR GEO; GSM844608 DR GEO; GSM887326 DR GEO; GSM888402 DR GEO; GSM1237677 DR GEO; GSM1237702 DR GEO; GSM1670114 DR IARC_TP53; 13723 DR IARC_TP53; 21641 DR JCRB; FDSC0010 DR JCRB; JCRB0082 DR JCRB; JCRB1025 DR LiGeA; CCLE_388 DR LINCS_LDP; LCL-1885 DR PharmacoDB; MKN7_939_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1417 DR PubChem_Cell_line; CVCL_1417 DR RCB; RCB0999 DR RCB; RCB3687 DR TKG; TKG 0228 DR Wikidata; Q54905831 RX CelloPub=CLPUB00581; RX CelloPub=CLPUB00584; RX DOI=10.1016/B978-0-12-333530-2.50014-9; RX PubMed=1933850; RX PubMed=3962675; RX PubMed=6862145; RX PubMed=11107048; RX PubMed=15723654; RX PubMed=15767549; RX PubMed=15900046; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22336246; RX PubMed=22460905; RX PubMed=24587255; RX PubMed=24807215; RX PubMed=25343454; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=29435981; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=35839778; WW Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=MKN-7 CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR39 cancer cell line panel. CC Part of: JFCR45 cancer cell line panel. CC Population: Japanese. CC Doubling time: 64-66 hours (PubMed=3962675); 66 hours (PubMed=29435981); 86 hours (PubMed=25984343). CC HLA typing: A*24:02,24:02; B*07:02,48:01; C*04:01,08:03 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-low) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ser (c.832C>T); ClinVar=VCV000376642; Zygosity=Homozygous (PubMed=11107048; Cosmic-CLP=924250; DepMap=ACH-000678). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.09%; East Asian, North=81.05%; East Asian, South=18.37%; South Asian=0%; European, North=0%; European, South=0.49% (PubMed=30894373). CC Caution: TP53 mutation indicated incorrectly as being at p.Ile251Leu (c.751A>C) in PubMed=15900046. CC Discontinued: JCRB; JCRB0082; true. CC Discontinued: JCRB; FDSC0010; true. CC Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. ST Source(s): Cosmic-CLP=924250; JCRB=JCRB1025; PubMed=25877200; RCB=RCB0999; TKG=TKG 0228 ST Amelogenin: X ST CSF1PO: 10,13 ST D13S317: 8,12 ST D16S539: 9,10 ST D18S51: 13,18 ST D21S11: 29,32.2 ST D3S1358: 17 ST D5S818: 9,13 ST D7S820: 9 (JCRB=JCRB1025; PubMed=25877200; TKG=TKG 0228) ST D7S820: 9,11 (Cosmic-CLP=924250; RCB=RCB0999) ST D8S1179: 15 ST FGA: 23 ST Penta D: 10,11 ST Penta E: 18 ST TH01: 7,9 ST TPOX: 9 ST vWA: 17 DI NCIt; C5473; Gastric tubular adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 39Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 // RX CelloPub=CLPUB00581; RA Hojo H.; RT "Establishment of cultured cell lines of human stomach cancer origin RT and their morphological characteristics."; RL Niigata Igakkai Zasshi 91:737-763(1977). // RX CelloPub=CLPUB00584; RA Motoyama T., Hojo H., Suzuki T., Oboshi S.; RT "Evaluation of the regrowth assay method as an in vitro drug sensitivity RT test and its application to cultured human gastric cancer cell lines."; RL Acta Med. Biol. 27:49-63(1979). // RX DOI=10.1016/B978-0-12-333530-2.50014-9; RA Sekiguchi M., Suzuki T.; RT "Gastric tumor cell lines."; RL (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994). // RX PubMed=1933850; RA Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., RA Nakatani K., Nakano H., Sugimura T., Terada M.; RT "p53 gene mutations in gastric cancer metastases and in gastric cancer RT cell lines derived from metastases."; RL Cancer Res. 51:5800-5805(1991). // RX PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x; RA Motoyama T., Hojo H., Watanabe H.; RT "Comparison of seven cell lines derived from human gastric RT carcinomas."; RL Acta Pathol. Jpn. 36:65-83(1986). // RX PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240; RA Naito S., Inoue S., Kinjo M., Tanaka K.; RT "Thromboplastic and fibrinolytic activities of cultured human gastric RT cancer cell lines."; RL Gann 74:240-247(1983). // RX PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x; RA Yokozaki H.; RT "Molecular characteristics of eight gastric cancer cell lines RT established in Japan."; RL Pathol. Int. 50:767-777(2000). // RX PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020; RA Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., RA Okanoue T., Inazawa J.; RT "Screening of DNA copy-number aberrations in gastric cancer cell lines RT by array-based comparative genomic hybridization."; RL Cancer Sci. 96:100-110(2005). // RX PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234; RA Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., RA Yamori T.; RT "Chemosensitivity profile of cancer cell lines and identification of RT genes determining chemosensitivity by an integrated bioinformatical RT approach using cDNA arrays."; RL Mol. Cancer Ther. 4:399-412(2005). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., RA Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y., RA Tomoda H., Yamori T., Tsuruo T.; RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., RA Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., RA Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., RA Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.; RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., RA Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., RA Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., RA Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., RA Haber D.A.; RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong D.-X., Yamori T.; RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., RA Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., RA Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., RA Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., RA Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., RA Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., RA Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., RA Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., RA Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., RA Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., RA Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.; RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=24587255; DOI=10.1371/journal.pone.0090155; PMCID=PMC3937424; RA Endo F., Nishizuka S.S., Kume K., Ishida K., Katagiri H., Ishida K., RA Sato K., Iwaya T., Koeda K., Wakabayashi G.; RT "A compensatory role of NF-kappaB to p53 in response to 5-FU-based RT chemotherapy for gastric cancer cell lines."; RL PLoS ONE 9:e90155.1-e90155.8(2014). // RX PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760; RA Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., RA Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., RA Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., RA Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., RA Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., RA Firestein R., Zhang Z.-M.; RT "Integrated exome and transcriptome sequencing reveals ZAK isoform RT usage in gastric cancer."; RL Nat. Commun. 5:3830.1-3830.8(2014). // RX PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810; RA Choong M.-L., Tan S.-H., Tan T.-Z., Manesh S., Ngo A., Yong J.W.-Y., RA Yang H.H., Lee M.A.; RT "Molecular integrative clustering of Asian gastric cell lines revealed RT two distinct chemosensitivity clusters."; RL PLoS ONE 9:e111146.1-e111146.9(2014). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., RA Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., RA Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., RA Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., RA Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., RA Settleman J., Seshagiri S., Zhang Z.-M.; RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., RA Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., RA Neve R.M.; RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., RA East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., RA Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., RA Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., RA Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., RA Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., RA Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., RA Golub T.R., Root D.E., Hahn W.C.; RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., RA Loewer M., Sahin U., Castle J.C.; RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., RA Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., RA Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., RA Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., RA Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., RA Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., RA Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., RA Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.; RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=29435981; DOI=10.1002/ijc.31304; RA Kim H.J., Kang S.K., Kwon W.S., Kim T.S., Jeong I., Jeung H.-C., RA Kragh M., Horak I.D., Chung H.C., Rha S.Y.; RT "Forty-nine gastric cancer cell lines with integrative genomic RT profiling for development of c-MET inhibitor."; RL Int. J. Cancer 143:151-159(2018). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.; RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., RA McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., RA Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., RA Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., RA Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., RA Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., RA Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., RA Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., RA Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., RA Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., RA Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., RA Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., RA Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., RA Sellers W.R.; RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, RA Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., RA Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., RA Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., RA Sellers W.R., Gygi S.P.; RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., RA Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., RA Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., RA Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., RA Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., RA Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.; RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). //