ID MKN28 AC CVCL_1416 SY MKN-28; MKN 28 DR BTO; BTO_0002381 DR CLO; CLO_0037142 DR EFO; EFO_0002831 DR ABM; T9192 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 944 DR BioSample; SAMN03151847 DR cancercelllines; CVCL_1416 DR Cell_Model_Passport; SIDM00260 DR CGH-DB; 119-1 DR CGH-DB; 9021-4 DR ChEMBL-Cells; CHEMBL3307602 DR ChEMBL-Targets; CHEMBL614353 DR Cosmic; 801338 DR Cosmic; 848146 DR Cosmic; 848371 DR Cosmic; 873710 DR Cosmic; 875905 DR Cosmic; 877041 DR Cosmic; 887249 DR Cosmic; 888826 DR Cosmic; 897534 DR Cosmic; 908139 DR Cosmic; 918496 DR Cosmic; 922694 DR Cosmic; 926113 DR Cosmic; 968348 DR Cosmic; 983726 DR Cosmic; 1066230 DR Cosmic; 1067208 DR Cosmic; 1090460 DR Cosmic; 1093298 DR Cosmic; 1223588 DR Cosmic; 1436025 DR Cosmic; 1460710 DR Cosmic; 1482081 DR Cosmic; 1627264 DR Cosmic; 1995509 DR Cosmic; 2036660 DR Cosmic; 2069778 DR Cosmic; 2823226 DR Cosmic-CLP; 908139 DR DepMap; ACH-002161 DR EGA; EGAS00001000978 DR GDSC; 908139 DR GEO; GSM562396 DR GEO; GSM1670112 DR IARC_TP53; 972 DR IARC_TP53; 21505 DR JCRB; FDSC0011 DR JCRB; JCRB0253 DR JCRB; NIHS0324 DR JCRB; NIHS0325 DR KCLB; 80102 DR LINCS_LDP; LCL-1922 DR PharmacoDB; MKN28_937_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1416 DR PubChem_Cell_line; CVCL_1416 DR RCB; RCB1000 DR Wikidata; Q54905823 RX CelloPub=CLPUB00581; RX CelloPub=CLPUB00584; RX DOI=10.1016/B978-0-12-333530-2.50014-9; RX PubMed=758928; RX PubMed=1370612; RX PubMed=1933850; RX PubMed=3962675; RX PubMed=3986962; RX PubMed=6862145; RX PubMed=9023415; RX PubMed=9290701; RX PubMed=11107048; RX PubMed=11314020; RX PubMed=15723654; RX PubMed=15767549; RX PubMed=15900046; RX PubMed=15901131; RX PubMed=20143388; RX PubMed=20164919; RX PubMed=22336246; RX PubMed=22490663; RX PubMed=23671654; RX PubMed=25960936; RX PubMed=27397505; RX PubMed=29435981; RX PubMed=29717028; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=35839778; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx WW Info; JCRB; -; https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm CC Problematic cell line: Contaminated. Shown to be a MKN74 derivative (PubMed=20143388). CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR39 cancer cell line panel. CC Part of: JFCR45 cancer cell line panel. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00328. CC Population: Japanese. CC Doubling time: 28-32 hours (PubMed=3962675); 28 hours (PubMed=29435981); 30-34 hours (CelloPub=CLPUB00584). CC HLA typing: A*31:01; B*51:01; C*03:04 (PubMed=9023415). CC HLA typing: B*51:01; C*03:04,03:04; DRB1*15:01,15:01 (PubMed=25960936). CC Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Leu (c.751A>C); ClinVar=VCV000182937; Zygosity=Unspecified (PubMed=1370612; PubMed=11107048; PubMed=15900046; PubMed=15901131; PubMed=22490663). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=83.28%; East Asian, South=16.71%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373). CC Discontinued: JCRB; NIHS0324; true. CC Discontinued: JCRB; NIHS0325; true. CC Discontinued: JCRB; FDSC0011; true. CC Discontinued: RCB; RCB1000; true. CC Derived from site: Metastatic; Liver; UBERON=UBERON_0002107. ST Source(s): Cosmic-CLP=908139; JCRB=JCRB0253; KCLB=80102; RCB=RCB1000 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 11 ST D16S539: 9,11 ST D3S1358: 16 ST D5S818: 11 ST D7S820: 9 ST FGA: 23 ST TH01: 6 ST TPOX: 8,11 ST vWA: 16,20 DI NCIt; C5473; Gastric tubular adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_2791 ! MKN74 SX Male AG 37Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 45 CH CVCL_UW56 ! MKN28-EGFP CH CVCL_QZ55 ! RMKN-28 // RX PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0; RA Matozaki, Takashi RA Sakamoto, Choitsu RA Matsuda, Kohei RA Suzuki, Toshiya RA Konda, Yoshitaka RA Nakano, Osamu RA Wada, Ken RA Uchida, Tohru RA Nishisaki, Hogara RA Nagao, Munehiko RA Kasuga, Masato RT "Missense mutations and a deletion of the p53 gene in human gastric RT cancer."; RL Biochem. Biophys. Res. Commun. 182:215-223(1992). // RX PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x; RA Yokozaki, Hiroshi RT "Molecular characteristics of eight gastric cancer cell lines RT established in Japan."; RL Pathol. Int. 50:767-777(2000). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX DOI=10.1016/B978-0-12-333530-2.50014-9; RA Sekiguchi, Morimasa RA Suzuki, Toshimitsu RT "Gastric tumor cell lines."; RL (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.287-316; Academic Press; New York; USA (1994). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong, De-Xin RA Yamori, Takao RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x; RA Motoyama, Teiichi RA Hojo, Haruto RA Watanabe, Hidenobu RT "Comparison of seven cell lines derived from human gastric RT carcinomas."; RL Acta Pathol. Jpn. 36:65-83(1986). // RX PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234; RA Nakatsu, Noriyuki RA Yoshida, Yoko RA Yamazaki, Kanami RA Nakamura, Tomoki RA Dan, Shingo RA Fukui, Yasuhisa RA Yamori, Takao RT "Chemosensitivity profile of cancer cell lines and identification of RT genes determining chemosensitivity by an integrated bioinformatical RT approach using cDNA arrays."; RL Mol. Cancer Ther. 4:399-412(2005). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030; RA Lu, Yu-Heng RA Soong, T. David RA Elemento, Olivier RT "A novel approach for characterizing microsatellite instability in RT cancer cells."; RL PLoS ONE 8:e63056.1-e63056.10(2013). // RX PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020; RA Takada, Hisashi RA Imoto, Issei RA Tsuda, Hitoshi RA Sonoda, Itaru RA Ichikura, Takashi RA Mochizuki, Hidetaka RA Okanoue, Takeshi RA Inazawa, Johji RT "Screening of DNA copy-number aberrations in gastric cancer cell lines RT by array-based comparative genomic hybridization."; RL Cancer Sci. 96:100-110(2005). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima, Tetsuo RA Oh-hara, Tomoko RA Sato, Shigeo RA Mochizuki, Mikiko RA Sugimoto, Yoshikazu RA Yamazaki, Kanami RA Hamada, Jun-ichi RA Tada, Mitsuhiro RA Moriuchi, Tetsuya RA Ishikawa, Yuichi RA Kato, Yo RA Tomoda, Hiroshi RA Yamori, Takao RA Tsuruo, Takashi RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240; RA Naito, Seiji RA Inoue, Sadami RA Kinjo, Mitsuru RA Tanaka, Kenzo RT "Thromboplastic and fibrinolytic activities of cultured human gastric RT cancer cell lines."; RL Gann 74:240-247(1983). // RX PubMed=758928; DOI=10.1038/bjc.1979.3; PMCID=PMC2009802; RA Kinjo, Mitsuru RA Oka, Kazunari RA Naito, Seiji RA Kohga, Shin RA Tanaka, Kenzo RA Oboshi, Shoichi RA Hayata, Yoshihiro RA Yasumoto, Kosei RT "Thromboplastic and fibrinolytic activities of cultured human cancer RT cell lines."; RL Br. J. Cancer 39:15-23(1979). // RX PubMed=15901131; DOI=10.1016/j.prp.2005.01.002; RA Murai, Yoshihiro RA Hayashi, Shinichi RA Takahashi, Hiroyuki RA Tsuneyama, Koichi RA Takano, Yasuo RT "Correlation between DNA alterations and p53 and p16 protein RT expression in cancer cell lines."; RL Pathol. Res. Pract. 201:109-115(2005). // RX CelloPub=CLPUB00584; RA Motoyama, Teiichi RA Hojo, Haruto RA Suzuki, Toshimitsu RA Oboshi, Shoichi RT "Evaluation of the regrowth assay method as an in vitro drug sensitivity RT test and its application to cultured human gastric cancer cell lines."; RL Acta Med. Biol. 27:49-63(1979). // RX PubMed=29435981; DOI=10.1002/ijc.31304; RA Kim, Hyun Jeong RA Kang, Sun Kyoung RA Kwon, Woo Sun RA Kim, Tae Soo RA Jeong, Inhye RA Jeung, Hei-Cheul RA Kragh, Michael RA Horak, Ivan D. RA Chung, Hyun Cheol RA Rha, Sun Young RT "Forty-nine gastric cancer cell lines with integrative genomic RT profiling for development of c-MET inhibitor."; RL Int. J. Cancer 143:151-159(2018). // RX PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122; RA Saiki, Yuriko RA Yoshino, Yuki RA Fujimura, Hiroko RA Manabe, Tatsuya RA Kudo, Yuki RA Shimada, Miki RA Mano, Nariyasu RA Nakano, Tomohiro RA Lee, Yoonha RA Shimizu, Shinjiro RA Oba, Shinya RA Fujiwara, Sho RA Shimizu, Hideyuki RA Chen, Na RA Nezhad, Zhaleh Kashkouli RA Jin, Guo RA Fukushige, Shinichi RA Sunamura, Makoto RA Ishida, Masaharu RA Motoi, Fuyuhiko RA Egawa, Shinichi RA Unno, Michiaki RA Horii, Akira RT "DCK is frequently inactivated in acquired gemcitabine-resistant human RT cancer cells."; RL Biochem. Biophys. Res. Commun. 421:98-104(2012). // RX PubMed=20143388; DOI=10.1002/ijc.25242; RA Capes-Davis, Amanda RA Theodosopoulos, George RA Atkin, Isobel RA Drexler, Hans Gunther RA Kohara, Arihiro RA MacLeod, Roderick A.F. RA Masters, John R.W. RA Nakamura, Yukio RA Reid, Yvonne A. RA Reddel, Roger Robert RA Freshney, Robert Ian RT "Check your cultures! A list of cross-contaminated or misidentified RT cell lines."; RL Int. J. Cancer 127:1-8(2010). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=11314020; DOI=10.1038/sj.onc.1204160; RA Kataoka, Hiromi RA Miura, Yutaka RA Joh, Takashi RA Seno, Kyoji RA Tada, Toyohiro RA Tamaoki, Taiki RA Nakabayashi, Hidekazu RA Kawaguchi, Makoto RA Asai, Kiyofumi RA Kato, Taiji RA Itoh, Makoto RT "Alpha-fetoprotein producing gastric cancer lacks transcription factor RT ATBF1."; RL Oncogene 20:869-873(2001). // RX CelloPub=CLPUB00581; RA Hojo, Haruto RT "Establishment of cultured cell lines of human stomach cancer origin RT and their morphological characteristics."; RL Niigata Igakkai Zasshi 91:737-763(1977). // RX PubMed=9023415; DOI=10.1006/cimm.1996.1062; RA Seki, Naoko RA Hoshino, Tomoaki RA Kikuchi, Megumi RA Hayashi, Akihiro RA Itoh, Kyogo RT "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating RT lymphocytes of patients with non-small cell lung cancer."; RL Cell. Immunol. 175:101-110(1997). // RX PubMed=29717028; DOI=10.1042/BSR20180277; PMCID=PMC6050193; RA Zhang, Ye-Qian RA Yu, Si-Te RA Zhang, Zi-Zhen RA Zhao, Gang RA Xu, Jia RT "Long non-coding RNA AK096174 promotes cell proliferation and invasion RT in gastric cancer by regulating WDR66 expression."; RL Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel, Sebastian RA Lower, Martin RA Bukur, Thomas RA Sahin, Ugur RA Castle, John C. RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=3986962; DOI=10.1093/carcin/6.4.549; RA Watatani, Masahiro RA Ikenaga, Mituo RA Hatanaka, Toshihiro RA Kinuta, Masakatsu RA Takai, Shin-ichiro RA Mori, Takesada RA Kondo, Sohei RT "Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA RT damage in tumor cell strains from Japanese patients and demonstration RT of MNNG hypersensitivity of Mer xenografts in athymic nude mice."; RL Carcinogenesis 6:549-553(1985). // RX PubMed=1933850; RA Yamada, Yukishige RA Yoshida, Teruhiko RA Hayashi, Kenshi RA Sekiya, Takao RA Yokota, Jun RA Hirohashi, Setsuo RA Nakatani, Katsunori RA Nakano, Hiroshige RA Sugimura, Takashi RA Terada, Masaaki RT "p53 gene mutations in gastric cancer metastases and in gastric cancer RT cell lines derived from metastases."; RL Cancer Res. 51:5800-5805(1991). //