ID Mel Ho AC CVCL_1402 SY MEL HO; MEL-HO; MEL-Ho; Mel-HO; MelHo; MELHO; Ho DR BTO; BTO_0001587 DR CLO; CLO_0007675 DR EFO; EFO_0006647 DR CLDB; cl3439 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 549 DR BioSample; SAMN03152032 DR BioSample; SAMN03473130 DR BioSample; SAMN03473505 DR BioSample; SAMN10988268 DR cancercelllines; CVCL_1402 DR Cell_Model_Passport; SIDM00337 DR ChEMBL-Cells; CHEMBL3308798 DR ChEMBL-Targets; CHEMBL1075500 DR Cosmic; 908124 DR Cosmic; 1995504 DR Cosmic-CLP; 908124 DR DepMap; ACH-000450 DR DSMZ; ACC-62 DR DSMZCellDive; ACC-62 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR GDSC; 908124 DR GEO; GSM887308 DR GEO; GSM888384 DR GEO; GSM1670094 DR IARC_TP53; 21492 DR LiGeA; CCLE_006 DR LINCS_LDP; LCL-1251 DR PharmacoDB; MELHO_914_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1402 DR PubChem_Cell_line; CVCL_1402 DR Wikidata; Q54905059 RX PubMed=6895502; RX PubMed=10508494; RX PubMed=11668190; RX PubMed=20143388; RX PubMed=20164919; RX PubMed=22170099; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Misidentified/contaminated. Shown to be identical to MEL-Wei. This cell line was reported to be isogenic with LCL-Ho (Cellosaurus=CVCL_1868) but it does not have the same STR profile (PubMed=10508494; PubMed=20143388). According to DSMZ ACC-62 it is a human female cell line. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00144. CC Population: Caucasian. CC Doubling time: ~24 hours (DSMZ=ACC-62). CC HLA typing: A*03:01,03:01; B*07:02,14:02; C*07:02,08:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (DepMap=ACH-000450). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=1.05%; East Asian, South=0%; South Asian=0%; European, North=64.35%; European, South=34.59% (PubMed=30894373). CC Derived from site: In situ; Skin; UBERON=UBERON_0002097. ST Source(s): Cosmic-CLP=908124; DSMZ=ACC-62; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 11 ST D16S539: 11 ST D18S51: 12,16 ST D19S433: 15 ST D21S11: 29 ST D2S1338: 23,24 ST D3S1358: 16,18 ST D5S818: 12 ST D7S820: 10 (PubMed=25877200) ST D7S820: 10,11,13 (Cosmic-CLP=908124; DSMZ=ACC-62) ST D8S1179: 11,14 (PubMed=25877200) ST D8S1179: 11,16 (DSMZ=ACC-62) ST FGA: 22,23 ST Penta D: 8,9 ST Penta E: 11,16 ST TH01: 7 ST TPOX: 8,10 ST vWA: 14,18 DI NCIt; C3224; Melanoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_3981 ! Mel Wei SX Female AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 44 CH CVCL_RQ53 ! MelHOrCDDP1000 CH CVCL_RQ54 ! MelHOrDACARB20 CH CVCL_RQ51 ! MelHOrNutlin20muM CH CVCL_RQ55 ! MelHOrPLX4032_10muM CH CVCL_RS67 ! MelHOrPLX4720_10muM CH CVCL_RQ52 ! MelHOrVCR20 // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2; RA MacLeod, Roderick A.F. RA Dirks, Wilhelm Gerhard RA Matsuo, Yoshinobu RA Kaufmann, Maren RA Milch, Herbert RA Drexler, Hans Gunther RT "Widespread intraspecies cross-contamination of human tumor cell lines RT arising at source."; RL Int. J. Cancer 83:555-563(1999). // RX PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738; RA Michaelis, Martin RA Rothweiler, Florian RA Barth, Susanne RA Cinatl, Jaroslaw RA van Rikxoort, Marijke RA Loschmann, Nadine RA Voges, Yvonne RA Breitling, Rainer RA von Deimling, Andreas RA Rodel, Franz RA Weber, Kristoffer RA Fehse, Boris RA Mack, Elisabeth RA Stiewe, Thorsten RA Doerr, Hans-Wilhelm RA Speidel, Daniel RA Cinatl, Jindrich Jr. RT "Adaptation of cancer cells from different entities to the MDM2 RT inhibitor nutlin-3 results in the emergence of p53-mutated RT multi-drug-resistant cancer cells."; RL Cell Death Dis. 2:e243.1-e243.8(2011). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=6895502; DOI=10.1002/eji.1830111015; RA Johnson, Judith P. RA Demmer-Dieckmann, Maria RA Meo, Tommaso RA Hadam, Martin R. RA Riethmuller, Gert RT "Surface antigens of human melanoma cells defined by monoclonal RT antibodies. I. Biochemical characterization of two antigens found on RT cell lines and fresh tumors of diverse tissue origin."; RL Eur. J. Immunol. 11:825-831(1981). // RX PubMed=20143388; DOI=10.1002/ijc.25242; RA Capes-Davis, Amanda RA Theodosopoulos, George RA Atkin, Isobel RA Drexler, Hans Gunther RA Kohara, Arihiro RA MacLeod, Roderick A.F. RA Masters, John R.W. RA Nakamura, Yukio RA Reid, Yvonne A. RA Reddel, Roger Robert RA Freshney, Robert Ian RT "Check your cultures! A list of cross-contaminated or misidentified RT cell lines."; RL Int. J. Cancer 127:1-8(2010). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). //