ID ME-180 AC CVCL_1401 SY Me-180; ME 180; ME180 DR CLO; CLO_0007657 DR CLO; CLO_0050924 DR EFO; EFO_0006646 DR CLDB; cl3429 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-7932 DR ATCC; HTB-33 DR BioSample; SAMN03471125 DR BioSample; SAMN03472007 DR BioSample; SAMN03472511 DR BioSample; SAMN03473047 DR cancercelllines; CVCL_1401 DR CCRID; 3101HUMTCHu177 DR Cell_Model_Passport; SIDM00627 DR ChEMBL-Cells; CHEMBL3308114 DR ChEMBL-Targets; CHEMBL1075499 DR CLS; 300196 DR Cosmic; 687514 DR Cosmic; 760223 DR Cosmic; 809228 DR Cosmic; 846185 DR Cosmic; 877466 DR Cosmic; 928909 DR Cosmic; 1071909 DR Cosmic; 1102582 DR Cosmic; 1131524 DR Cosmic; 1175837 DR Cosmic; 1176609 DR Cosmic; 1193031 DR Cosmic; 1995503 DR Cosmic; 2301541 DR Cosmic; 2546868 DR Cosmic; 2660192 DR Cosmic; 2816215 DR Cosmic-CLP; 687514 DR DepMap; ACH-001359 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10553-107I4 DR GDSC; 687514 DR GEO; GSM113864 DR GEO; GSM253300 DR GEO; GSM595618 DR GEO; GSM675736 DR GEO; GSM685436 DR GEO; GSM827202 DR GEO; GSM1670090 DR IARC_TP53; 21490 DR ICLC; HTL96027 DR IGRhCellID; ME180%20GEO DR JCRB; JCRB0810 DR KCLB; 30033 DR LINCS_LDP; LCL-1305 DR PharmacoDB; ME180_910_2019 DR PRIDE; PXD003668 DR PRIDE; PXD030304 DR Progenetix; CVCL_1401 DR PubChem_Cell_line; CVCL_1401 DR RCB; RCB2106 DR TKG; TKG 0437 DR TOKU-E; 2410 DR Wikidata; Q54904901 RX DOI=10.1007/978-1-4757-1647-4_13; RX PubMed=77569; RX PubMed=327080; RX PubMed=833871; RX PubMed=2990217; RX PubMed=3371749; RX PubMed=3518877; RX PubMed=4317734; RX PubMed=6220172; RX PubMed=6500159; RX PubMed=6582512; RX PubMed=7017212; RX PubMed=7459858; RX PubMed=7751322; RX PubMed=8380785; RX PubMed=8931502; RX PubMed=9290701; RX PubMed=9887230; RX PubMed=15531914; RX PubMed=17325662; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22710073; RX PubMed=24134916; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=27561551; RX PubMed=29156801; RX PubMed=30894373; RX PubMed=35839778; WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-612.html CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). CC Population: Caucasian. CC Virology: Contains a complete HPV68 genome. CC Doubling time: 1.5 days (PubMed=29156801). CC HLA typing: A*01,11; B*05,08; C*w07 (PubMed=77569). CC HLA typing: A*01:01,32:03; B*08:01,44:02; C*05:01,07:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (Cosmic-CLP=687514; DepMap=ACH-001359). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9887230). CC Transformant: NCBI_TaxID; 45240; Human papillomavirus type 68 (HPV68). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.51%; Native American=0.16%; East Asian, North=1.49%; East Asian, South=0%; South Asian=0%; European, North=64.3%; European, South=32.53% (PubMed=30894373). CC Discontinued: ATCC; CRL-7932; true. CC Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. ST Source(s): ATCC=HTB-33; CCRID=3101HUMTCHu177; CLS=300196; Cosmic-CLP=687514; JCRB=JCRB0810; KCLB=30033; PubMed=22710073; PubMed=25877200; PubMed=29156801; RCB=RCB2106; TKG=TKG 0437 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 11,12 (PubMed=22710073) ST D13S317: 11,13 (ATCC=HTB-33; CCRID=3101HUMTCHu177; CLS=300196; Cosmic-CLP=687514; JCRB=JCRB0810; KCLB=30033; PubMed=25877200; PubMed=29156801; RCB=RCB2106; TKG=TKG 0437) ST D16S539: 12,13 ST D18S51: 12 ST D19S433: 13,15.2 ST D21S11: 30,31 ST D2S1338: 18 ST D3S1358: 16 ST D5S818: 12 ST D7S820: 9,10 ST D8S1179: 14 ST FGA: 23 ST Penta D: 9,14 ST Penta E: 12,14 ST TH01: 8 (RCB=RCB2106) ST TH01: 8,9.3 (ATCC=HTB-33; CCRID=3101HUMTCHu177; CLS=300196; Cosmic-CLP=687514; JCRB=JCRB0810; KCLB=30033; PubMed=22710073; PubMed=25877200; PubMed=29156801; TKG=TKG 0437) ST TPOX: 8,10 ST vWA: 15,16,17 (JCRB=JCRB0810) ST vWA: 15,17 (ATCC=HTB-33; CCRID=3101HUMTCHu177; CLS=300196; Cosmic-CLP=687514; KCLB=30033; PubMed=22710073; PubMed=25877200; PubMed=29156801; RCB=RCB2106; TKG=TKG 0437) DI NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma DI ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 66Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 47 CH CVCL_KS60 ! CellSensor AP1-bla ME-180 CH CVCL_KS68 ! CellSensor c-fos-bla ME-180 CH CVCL_KS52 ! CellSensor GAS-bla ME-180 CH CVCL_KS07 ! CellSensor HRE-bla ME-180 CH CVCL_KB44 ! CellSensor NFkB-bla ME-180 CH CVCL_KS28 ! CellSensor SIE-bla ME-180 CH CVCL_0473 ! OV-2008 CH CVCL_6950 ! SF767 CH CVCL_A342 ! TSGH-8301 // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461; RA Coscia, Fabian RA Watters, Karen M. RA Curtis, Marion RA Eckert, Mark A. RA Chiang, Chun-Yi RA Tyanova, Stefka RA Montag, Anthony RA Lastra, Ricardo R. RA Lengyel, Ernst Robert RA Mann, Matthias RT "Integrative proteomic profiling of ovarian cancer cell lines reveals RT precursor cell associated proteins and functional status."; RL Nat. Commun. 7:12645.1-12645.14(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691; RA Kalu, Nene N. RA Mazumdar, Tuhina RA Peng, Shao-Hua RA Shen, Li RA Sambandam, Vaishnav RA Rao, Xia-Yu RA Xi, Yuan-Xin RA Li, Le-Rong RA Qi, Yuan RA Gleber-Netto, Frederico O. RA Patel, Ameeta RA Wang, Jing RA Frederick, Mitchell J. RA Myers, Jeffrey N. RA Pickering, Curtis R. RA Johnson, Faye M. RT "Genomic characterization of human papillomavirus-positive and RT -negative human squamous cell cancer cell lines."; RL Oncotarget 8:86369-86383(2017). // RX PubMed=7751322; DOI=10.1007/BF01366967; RA Rantanen, Virpi RA Grenman, Seija E. RA Kulmala, Jarmo RA Grenman, Reidar RT "The intrinsic radiosensitivity and sublethal damage repair capacity RT of five cervical carcinoma cell lines tested with the 96-well-plate RT assay."; RL J. Cancer Res. Clin. Oncol. 121:230-234(1995). // RX PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223; RA McCormack, Amanda RA Fan, Jiang-Lan RA Duesberg, Max RA Bloomfield, Mathew RA Fiala, Christian RA Duesberg, Peter Heinz RT "Individual karyotypes at the origins of cervical carcinomas."; RL Mol. Cytogenet. 6:44.1-44.23(2013). // RX PubMed=327080; DOI=10.1093/jnci/59.1.221; RA Fogh, Jorgen RA Fogh, Jens M. RA Orfeo, Thomas RT "One hundred and twenty-seven cultured human tumor cell lines RT producing tumors in nude mice."; RL J. Natl. Cancer Inst. 59:221-226(1977). // RX PubMed=8380785; DOI=10.1006/gyno.1993.1016; RA Iwasaka, Tsuyoshi RA Oh-uchida, Mamoru RA Matsuo, Norihito RA Yokoyama, Masatoshi RA Fukuda, Kouichi RA Hara, Kouichi RA Fukuyama, Kouzo RA Hori, Katsuji RA Sugimori, Hajime RT "Correlation between HPV positivity and state of the p53 gene in RT cervical carcinoma cell lines."; RL Gynecol. Oncol. 48:104-109(1993). // RX PubMed=7459858; RA Rousset, Monique RA Zweibaum, Alain RA Fogh, Jorgen RT "Presence of glycogen and growth-related variations in 58 cultured RT human tumor cell lines of various tissue origins."; RL Cancer Res. 41:1165-1170(1981). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x; RA Espmark, Jons Ake RA Ahlqvist-Roth, Lena RA Sarne, Lena RA Persson, Anita RT "Tissue typing of cells in culture. III. HLA antigens of established RT human cell lines. Attempts at typing by the mixed hemadsorption RT technique."; RL Tissue Antigens 11:279-286(1978). // RX PubMed=15531914; DOI=10.1038/sj.onc.1208235; RA Baldus, Stefan E. RA Schwarz, Elisabeth RA Lohrey, Claudia RA Zapatka, Marc RA Landsberg, Stephanie RA Hahn, Stephan A. RA Schmidt, Dietmar RA Dienes, Hans-Peter RA Schmiegel, Wolff Helmut RA Schwarte-Waldhoff, Irmgard RT "Smad4 deficiency in cervical carcinoma cells."; RL Oncogene 24:810-819(2005). // RX PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677; RA Korch, Christopher T. RA Spillman, Monique A. RA Jackson, Twila A. RA Jacobsen, Britta M. RA Murphy, Susan K. RA Lessey, Bruce Arthur RA Jordan, Virgil Craig RA Bradford, Andrew Peter RT "DNA profiling analysis of endometrial and ovarian cell lines reveals RT misidentification, redundancy and contamination."; RL Gynecol. Oncol. 127:241-248(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=4317734; DOI=10.1093/jnci/45.1.107; RA Sykes, John A. RA Whitescarver, Jack RA Jernstrom, Paul Herbert RA Nolan, James F. RA Byatt, Pamela Hilda RT "Some properties of a new epithelial cell line of human origin."; RL J. Natl. Cancer Inst. 45:107-122(1970). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=3518877; DOI=10.3109/07357908609038260; RA Fogh, Jorgen RT "Human tumor lines for cancer research."; RL Cancer Invest. 4:157-184(1986). // RX PubMed=2990217; PMCID=PMC1888002; RA Yee, Carole RA Krishnan-Hewlett, Indira RA Baker, Carl C. RA Schlegel, Richard RA Howley, Peter Maxwell RT "Presence and expression of human papillomavirus sequences in human RT cervical carcinoma cell lines."; RL Am. J. Pathol. 119:361-366(1985). // RX PubMed=8931502; DOI=10.3109/00016349609054706; RA Iwasaka, Tsuyoshi RA Zheng, Peng-Sheng RA Ouchida, Mamoru RA Yamasaki, Humio RA Yokoyama, Masatoshi RA Sugimori, Hajime RT "Cytologic changes in two cervical carcinoma cell lines after RT transfection of the wild-type p53 gene."; RL Acta Obstet. Gynecol. Scand. 75:797-803(1996). // RX PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720; RA Mattes, Michael Jules RA Cordon-Cardo, Carlos RA Lewis, John L. Jr. RA Old, Lloyd John RA Lloyd, Kenneth Oliver RT "Cell surface antigens of human ovarian and endometrial carcinoma RT defined by mouse monoclonal antibodies."; RL Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984). // RX PubMed=6220172; RA Dracopoli, Nicholas C. RA Fogh, Jorgen RT "Polymorphic enzyme analysis of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 70:469-476(1983). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7; RA Grenman, Seija E. RA Shapira, Amnon RA Carey, Thomas E. RT "In vitro response of cervical cancer cell lines CaSki, HeLa, and RT ME-180 to the antiestrogen tamoxifen."; RL Gynecol. Oncol. 30:228-238(1988). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=17325662; DOI=10.1038/sj.onc.1210330; RA Nakaya, K. RA Yamagata, Hidehisa D. RA Arita, Norimasa RA Nakashiro, Koh-ichi RA Nose, Masato RA Miki, Tetsuro RA Hamakawa, Hiroyuki RT "Identification of homozygous deletions of tumor suppressor gene FAT RT in oral cancer using CGH-array."; RL Oncogene 26:5300-5308(2007). // RX PubMed=7017212; DOI=10.1093/jnci/66.6.1003; RA Pollack, Marilyn S. RA Heagney, Socorro D. RA Livingston, Philip O. RA Fogh, Jorgen RT "HLA-A, B, C and DR alloantigen expression on forty-six cultured human RT tumor cell lines."; RL J. Natl. Cancer Inst. 66:1003-1012(1981). // RX PubMed=6500159; DOI=10.1159/000163283; RA Gershwin, Merrill Eric RA Lentz, Daniel RA Owens, Robert B. RT "Relationship between karyotype of tissue culture lines and RT tumorigenicity in nude mice."; RL Exp. Cell Biol. 52:361-370(1984). // RX PubMed=833871; DOI=10.1093/jnci/58.2.209; RA Fogh, Jorgen RA Wright, William C. RA Loveless, James D. RT "Absence of HeLa cell contamination in 169 cell lines derived from RT human tumors."; RL J. Natl. Cancer Inst. 58:209-214(1977). // RX PubMed=9887230; DOI=10.1006/gyno.1998.5194; RA Rantanen, Virpi RA Grenman, Seija E. RA Kurvinen, Kaisa RA Hietanen, Sakari H. RA Raitanen, Misa RA Syrjanen, Stina M. RT "p53 mutations and presence of HPV DNA do not correlate with RT radiosensitivity of gynecological cancer cell lines."; RL Gynecol. Oncol. 71:352-358(1998). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX DOI=10.1007/978-1-4757-1647-4_13; RA Biedler, June Lee RT "Chromosome abnormalities in human tumor cells in culture."; RL (In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.359-394; Springer; New York; USA (1975). //