ID KYSE-70 AC CVCL_1356 SY KYSE 70; KYSE70; Kyse70; KY70 DR CLO; CLO_0007137 DR EFO; EFO_0006633 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 573 DR BioSample; SAMN03471054 DR BioSample; SAMN03471650 DR BioSample; SAMN10988277 DR cancercelllines; CVCL_1356 DR Cell_Model_Passport; SIDM01024 DR CGH-DB; 275-1 DR CGH-DB; 9224-4 DR ChEMBL-Cells; CHEMBL3308390 DR ChEMBL-Targets; CHEMBL614012 DR Cosmic; 753576 DR Cosmic; 918523 DR Cosmic; 929521 DR Cosmic; 1123335 DR Cosmic; 1581070 DR Cosmic; 1876251 DR Cosmic; 2395008 DR Cosmic; 2698431 DR Cosmic-CLP; 753576 DR DepMap; ACH-000784 DR DSMZ; ACC-363 DR DSMZCellDive; ACC-363 DR ECACC; 94072012 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 753576 DR GEO; GSM590309 DR GEO; GSM827537 DR GEO; GSM887256 DR GEO; GSM888331 DR GEO; GSM1374613 DR GEO; GSM1670026 DR IARC_TP53; 7690 DR IARC_TP53; 21454 DR JCRB; JCRB0190 DR LiGeA; CCLE_812 DR LINCS_LDP; LCL-1557 DR PharmacoDB; KYSE70_812_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1356 DR PubChem_Cell_line; CVCL_1356 DR Wikidata; Q54900836 RX PubMed=1728357; RX PubMed=7913084; RX PubMed=8575860; RX PubMed=9033652; RX PubMed=11092977; RX PubMed=15172977; RX PubMed=16045545; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=21191746; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26512696; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Virology: Infected with a murine leukemia virus-related virus (PubMed=30629668). CC Doubling time: 17.1 hours (PubMed=1728357); ~35 hours (DSMZ=ACC-363; ECACC=94072012); ~25 hours (Note=Lot 06102005) (JCRB=JCRB0190). CC HLA typing: A*26:01,26:01; B*08:01,56:01; C*01:02,01:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Arg1989Ter (c.5965C>T); ClinVar=VCV000225842; Zygosity=Homozygous (Cosmic-CLP=753576; DepMap=ACH-000784). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys120Asn (c.360G>T); Zygosity=Heterozygous (Cosmic-CLP=753576; DepMap=ACH-000784). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thrfs*13 (c.751_752insA); Zygosity=Heterozygous (Cosmic-CLP=753576; DepMap=ACH-000784). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.22%; Native American=0%; East Asian, North=75.55%; East Asian, South=23.91%; South Asian=0.33%; European, North=0%; European, South=0% (PubMed=30894373). CC Caution: TP53 mutation indicated as c.750_751insC in PubMed=8575860. CC Derived from site: In situ; Esophagus; UBERON=UBERON_0001043. ST Source(s): Cosmic-CLP=753576; DSMZ=ACC-363; ECACC=94072012; JCRB=JCRB0190; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 11,12 ST D16S539: 13 ST D18S51: 13 ST D19S433: 13,16 ST D21S11: 30 ST D2S1338: 16 ST D3S1358: 15 ST D5S818: 12 ST D7S820: 8,11 ST D8S1179: 12 ST FGA: 21 ST Penta D: 9 ST Penta E: 11 ST TH01: 7 ST TPOX: 8 ST vWA: 16,18 DI NCIt; C4024; Esophageal squamous cell carcinoma DI ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 77Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 46 // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=11092977; DOI=10.1111/j.1349-7006.2000.tb00895.x; PMCID=PMC5926289; RA Pimkhaokham, Atiphan RA Shimada, Yutaka RA Fukuda, Yohji RA Kurihara, Naoki RA Imoto, Issei RA Yang, Zeng-Quan RA Imamura, Masayuki RA Nakamura, Yusuke RA Amagasa, Teruo RA Inazawa, Johji RT "Nonrandom chromosomal imbalances in esophageal squamous cell RT carcinoma cell lines: possible involvement of the ATF3 and CENPF genes RT in the 1q32 amplicon."; RL Jpn. J. Cancer Res. 91:1126-1133(2000). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=26512696; DOI=10.3390/cancers7040881; PMCID=PMC4695881; RA O'Callaghan, Carol RA Fanning, Liam J. RA Barry, Orla P. RT "Hypermethylation of MAPK13 promoter in oesophageal squamous cell RT carcinoma is associated with loss of p38delta MAPK expression."; RL Cancers (Basel) 7:2124-2133(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin K. RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=21191746; DOI=10.1007/s11684-010-0260-x; RA Ji, Jun-Fang RA Wu, Kun RA Wu, Min RA Zhan, Qi-Min RT "p53 functional activation is independent of its genotype in five RT esophageal squamous cell carcinoma cell lines."; RL Front. Med. China 4:412-418(2010). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=7913084; DOI=10.1002/ijc.2910580224; RA Kanda, Yuji RA Nishiyama, Yasuyuki RA Shimada, Yutaka RA Imamura, Masayuki RA Nomura, Hiroshi RA Hiai, Hiroshi RA Fukumoto, Manabu RT "Analysis of gene amplification and overexpression in human RT esophageal-carcinoma cell lines."; RL Int. J. Cancer 58:291-297(1994). // RX PubMed=15172977; DOI=10.1158/0008-5472.CAN-04-0172; RA Sonoda, Itaru RA Imoto, Issei RA Inoue, Jun RA Shibata, Tatsuhiro RA Shimada, Yutaka RA Chin, Koei RA Imamura, Masayuki RA Amagasa, Teruo RA Gray, Joe W. RA Hirohashi, Setsuo RA Inazawa, Johji RT "Frequent silencing of low density lipoprotein receptor-related RT protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in RT esophageal squamous cell carcinoma."; RL Cancer Res. 64:3741-3747(2004). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=16045545; DOI=10.1111/j.0959-9673.2005.00431.x; PMCID=PMC2517430; RA Ban, Sadayuki RA Michikawa, Yuichi RA Ishikawa, Ken-ichi RA Sagara, Masashi RA Watanabe, Koji RA Shimada, Yutaka RA Inazawa, Johji RA Imai, Takashi RT "Radiation sensitivities of 31 human oesophageal squamous cell RT carcinoma cell lines."; RL Int. J. Exp. Pathol. 86:231-240(2005). // RX PubMed=1728357; DOI=10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C; RA Shimada, Yutaka RA Imamura, Masayuki RA Wagata, Takashi RA Yamaguchi, Nozomi RA Tobe, Takayoshi RT "Characterization of 21 newly established esophageal cancer cell RT lines."; RL Cancer 69:277-284(1992). // RX PubMed=8575860; DOI=10.1002/(SICI)1097-0215(19960126)65:3<372::AID-IJC16>3.0.CO;2-C; RA Tanaka, Hisashi RA Shibagaki, Ichio RA Shimada, Yutaka RA Wagata, Takashi RA Imamura, Masayuki RA Ishizaki, Kanji RT "Characterization of p53 gene mutations in esophageal squamous cell RT carcinoma cell lines: increased frequency and different spectrum of RT mutations from primary tumors."; RL Int. J. Cancer 65:372-376(1996). // RX PubMed=9033652; DOI=10.1002/(SICI)1097-0215(19970207)70:4<437::AID-IJC11>3.0.CO;2-C; RA Tanaka, Hisashi RA Shimada, Yutaka RA Imamura, Masayuki RA Shibagaki, Ichio RA Ishizaki, Kanji RT "Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) RT genes in 30 esophageal squamous-cell-carcinoma cell lines."; RL Int. J. Cancer 70:437-442(1997). //