ID KY821 AC CVCL_1346 SY KY-821 DR CLO; CLO_0009844 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03470792 DR cancercelllines; CVCL_1346 DR Cell_Model_Passport; SIDM00553 DR ChEMBL-Cells; CHEMBL3308834 DR ChEMBL-Targets; CHEMBL2366190 DR Cosmic; 907300 DR Cosmic; 975264 DR Cosmic; 2089651 DR Cosmic; 2131567 DR Cosmic-CLP; 907300 DR DepMap; ACH-002262 DR EGA; EGAS00001000978 DR GDSC; 907300 DR GEO; GSM827265 DR GEO; GSM1670013 DR IARC_TP53; 2196 DR IARC_TP53; 21447 DR JCRB; JCRB0105 DR LINCS_LDP; LCL-1004 DR PharmacoDB; KY821_797_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1346 DR PubChem_Cell_line; CVCL_1346 DR Wikidata; Q54900774 RX CelloPub=CLPUB00069; RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=1560671; RX PubMed=1571549; RX PubMed=8387619; RX PubMed=9747033; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=21552520; RX PubMed=23955599; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: ~2 days (Note=Lot 11022006) (JCRB=JCRB0105). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (Cosmic-CLP=907300; DepMap=ACH-002262). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=1571549; Cosmic-CLP=907300; DepMap=ACH-002262). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=76.02%; East Asian, South=23.98%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373). CC Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743. ST Source(s): Cosmic-CLP=907300; JCRB=JCRB0105 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 9,12 ST D16S539: 10,12 ST D5S818: 10,13 ST D7S820: 12 ST TH01: 9 ST TPOX: 11 ST vWA: 17,18 DI NCIt; C7962; Adult acute myelomonocytic leukemia DI ORDO; Orphanet_517; Acute myelomonocytic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 28Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 40 CH CVCL_Z940 ! KY-ADR2 CH CVCL_W293 ! KY-MTX CH CVCL_W294 ! KY-Ra CH CVCL_5A05 ! KY-Rb CH CVCL_W295 ! KY-VCR CH CVCL_2806 ! KY821A3 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=9747033; DOI=10.1007/s100380050067; RA Ariyama, Yoji RA Sakabe, Tomoya RA Shinomiya, Takashi RA Mori, Toshiki RA Fukuda, Yoji RA Inazawa, Johji RT "Identification of amplified DNA sequences on double minute RT chromosomes in a leukemic cell line KY821 by means of spectral RT karyotyping and comparative genomic hybridization."; RL J. Hum. Genet. 43:187-190(1998). // RX PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H; RA Fukuda, Takeaki RA Kakihara, Toshio RA Kamishima, Tomoko RA Ohnishi, Yoshihisa RA Naito, Makoto RA Kishi, Kenji RA Shibata, Akira RT "Different effects of various hematopoietic growth factors on RT myelomonocytic cell line (KY-821) and its drug-resistant sublines."; RL Leuk. Res. 17:325-332(1993). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G; RA Saito, Hiroyuki RA Kishi, Kenji RA Narita, Miwako RA Furukawa, Tatsuo RA Nagura, Ei-ichi RA Maekawa, Taira RA Abe, Tatsuo RA Shibata, Akira RT "A new myeloblastic leukemia cell line with double minute chromosomes. RT Induction of methotrexate resistance and dihydrofolate reductase gene RT amplification."; RL Leuk. Res. 16:217-226(1992). // RX PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268; RA Gu, Ting-Lei RA Nardone, Julie RA Wang, Yi RA Loriaux, Marc RA Villen, Judit RA Beausoleil, Sean A. RA Tucker, Meghan RA Kornhauser, Jon M. RA Ren, Jian-Min RA MacNeill, Joan RA Gygi, Steven P. RA Druker, Brian Jay RA Heinrich, Michael Charles RA Rush, John RA Polakiewicz, Roberto D. RT "Survey of activated FLT3 signaling in leukemia."; RL PLoS ONE 6:e19169.1-e19169.10(2011). // RX PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378; RA Sugimoto, Koichi RA Toyoshima, Hideo RA Sakai, Ryuichi RA Miyagawa, Kiyoshi RA Hagiwara, Koichi RA Ishikawa, Fuyuki RA Takaku, Fumimaro RA Yazaki, Yoshio RA Hirai, Hisamaru RT "Frequent mutations in the p53 gene in human myeloid leukemia cell RT lines."; RL Blood 79:2378-2383(1992). // RX PubMed=23955599; DOI=10.1038/ng.2731; RA Kon, Ayana RA Shih, Lee-Yung RA Minamino, Masashi RA Sanada, Masashi RA Shiraishi, Yuichi RA Nagata, Yasunobu RA Yoshida, Ken-ichi RA Okuno, Yusuke RA Bando, Masashige RA Nakato, Ryuichiro RA Ishikawa, Shumpei RA Sato-Otsubo, Aiko RA Nagae, Genta RA Nishimoto, Aiko RA Haferlach, Claudia RA Nowak, Daniel RA Sato, Yusuke RA Alpermann, Tamara RA Nagasaki, Masao RA Shimamura, Teppei RA Tanaka, Hiroko RA Chiba, Kenichi RA Yamamoto, Ryo RA Yamaguchi, Tomoyuki RA Otsu, Makoto RA Obara, Naoshi RA Sakata-Yanagimoto, Mamiko RA Nakamaki, Tsuyoshi RA Ishiyama, Ken RA Nolte, Florian RA Hofmann, Wolf-Karsten RA Miyawaki, Shuichi RA Chiba, Shigeru RA Mori, Hiraku RA Nakauchi, Hiromitsu RA Koeffler, Harold Phillip RA Aburatani, Hiroyuki RA Haferlach, Torsten RA Shirahige, Katsuhiko RA Miyano, Satoru RA Ogawa, Seishi RT "Recurrent mutations in multiple components of the cohesin complex in RT myeloid neoplasms."; RL Nat. Genet. 45:1232-1237(2013). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX CelloPub=CLPUB00069; RA Kishi, Kenji RA Kano, Masaaki RA Hirosawa, Hideo RA Koike, Tadashi RA Sakai, Chikara RA Aoyagi, Noritaka RA Sanada, Masayoshi RA Moriyama, Yoshiaki RA Hattori, Akira RA Shibata, Akira RT "On the characteristics of a cell line (KY821) derived from acute RT myelogenous leukemia."; RL Acta Haematol. Jpn. 46:122.109-122.109(1983). //