ID KU-19-19 AC CVCL_1344 SY KU 19-19; KU19-19; KU1919; Keio University-19-19 DR CLO; CLO_0007123 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 608 DR BioSample; SAMN03473576 DR BioSample; SAMN10988557 DR cancercelllines; CVCL_1344 DR Cell_Model_Passport; SIDM01033 DR ChEMBL-Cells; CHEMBL3308111 DR ChEMBL-Targets; CHEMBL1075483 DR Cosmic; 907312 DR Cosmic; 1046693 DR Cosmic; 1285122 DR Cosmic; 1286001 DR Cosmic; 2050448 DR Cosmic; 2057453 DR Cosmic; 2444234 DR Cosmic; 2686100 DR Cosmic-CLP; 907312 DR DepMap; ACH-000486 DR DSMZ; ACC-395 DR DSMZCellDive; ACC-395 DR EGA; EGAS00001000978 DR ENCODE; ENCBS304FRD DR ENCODE; ENCBS497ZHB DR GDSC; 907312 DR GEO; GSM887243 DR GEO; GSM888317 DR GEO; GSM1374605 DR GEO; GSM1670010 DR IARC_TP53; 21445 DR LiGeA; CCLE_760 DR LINCS_LDP; LCL-1715 DR PharmacoDB; KU1919_794_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1344 DR PubChem_Cell_line; CVCL_1344 DR Wikidata; Q54900670 RX PubMed=7542171; RX PubMed=9464244; RX PubMed=10022529; RX PubMed=10496353; RX PubMed=19802009; RX PubMed=20164919; RX PubMed=22460905; RX PubMed=24035680; RX PubMed=24367658; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=29732388; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=35839778; WW Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KU-19-19 CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: ~48 hours (DSMZ=ACC-395). CC HLA typing: A*31:01,33:03; B*15:01,37:01; C*03:03,06:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Unspecified (PubMed=19802009). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=77.87%; East Asian, South=21.55%; South Asian=0%; European, North=0%; European, South=0.57% (PubMed=30894373). CC Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. ST Source(s): Cosmic-CLP=907312; DSMZ=ACC-395 ST Amelogenin: X ST CSF1PO: 9,10 ST D13S317: 11 ST D16S539: 10,12 ST D18S51: 17,20 ST D19S433: 13,15 ST D21S11: 30,32 ST D2S1338: 19 ST D3S1358: 16,17 ST D5S818: 11,12 ST D7S820: 10,12 ST D8S1179: 10,13 ST FGA: 22 ST Penta D: 13 ST Penta E: 10,15 ST TH01: 7,8 ST TPOX: 8,11 ST vWA: 14,15 DI NCIt; C4912; Bladder carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 76Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 // RX PubMed=7542171; RA Tachibana, Masaaki RA Miyakawa, Ayako RA Tazaki, Hiroshi RA Nakamura, Kayoko RA Kubo, Atsushi RA Hata, Jun-ichi RA Nishi, Tatsunari RA Amano, Yasuhiro RT "Autocrine growth of transitional cell carcinoma of the bladder RT induced by granulocyte-colony stimulating factor."; RL Cancer Res. 55:3438-3443(1995). // RX PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057; RA Hurst, Carolyn D. RA Platt, Fiona M. RA Knowles, Margaret Anne RT "Comprehensive mutation analysis of the TERT promoter in bladder RT cancer and detection of mutations in voided urine."; RL Eur. Urol. 65:367-369(2014). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350; RA Zuiverloon, Tahlita C.M. RA de Jong, Florus Christiaan RA Costello, James C. RA Theodorescu, Dan RT "Systematic review: characteristics and preclinical uses of bladder RT cancer cell lines."; RL Bladder Cancer 4:169-183(2018). // RX PubMed=10496353; DOI=10.1038/sj.bjc.6690688; PMCID=PMC2362876; RA Sumitomo, Makoto RA Tachibana, Masaaki RA Murai, Masaru RA Hayakawa, Masamichi RA Nakamura, Hiroshi RA Takayanagi, Atsushi RA Shimizu, Nobuyoshi RT "Overexpression of IL-1ra gene up-regulates interleukin-1beta RT converting enzyme (ICE) gene expression: possible mechanism underlying RT IL-1beta-resistance of cancer cells."; RL Br. J. Cancer 81:277-286(1999). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=9464244; DOI=10.1006/bbrc.1997.8002; RA Steube, Klaus G. RA Meyer, Corinna RA Tachibana, Masaaki RA Murai, Masaru RA Drexler, Hans Gunther RT "Bladder carcinoma cell line KU-19-19-derived cytokines support RT proliferation of growth factor-dependent hematopoietic cell lines: RT modulation by phorbol ester, interferon-gamma and interleukin-1 RT beta."; RL Biochem. Biophys. Res. Commun. 242:497-501(1998). // RX PubMed=24367658; DOI=10.1371/journal.pone.0084411; PMCID=PMC3867501; RA Ross, Rebecca L. RA Burns, Julie E. RA Taylor, Claire F. RA Mellor, Paul RA Anderson, Deborah H. RA Knowles, Margaret Anne RT "Identification of mutations in distinct regions of p85 alpha in RT urothelial cancer."; RL PLoS ONE 8:e84411.1-e84411.11(2013). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=10022529; DOI=10.1089/10430349950019174; RA Sumitomo, Makoto RA Tachibana, Masaaki RA Ozu, Choichiro RA Asakura, Hirotaka RA Murai, Masaru RA Hayakawa, Masamichi RA Nakamura, Hiroshi RA Takayanagi, Atsushi RA Shimizu, Nobuyoshi RT "Induction of apoptosis of cytokine-producing bladder cancer cells by RT adenovirus-mediated IkappaBalpha overexpression."; RL Hum. Gene Ther. 10:37-47(1999). // RX PubMed=19802009; DOI=10.1038/onc.2009.315; RA Askham, Jonathan M. RA Platt, Fiona M. RA Chambers, Philip A. RA Snowden, Helen RA Taylor, Claire F. RA Knowles, Margaret Anne RT "AKT1 mutations in bladder cancer: identification of a novel oncogenic RT mutation that can co-operate with E17K."; RL Oncogene 29:150-155(2010). //