ID   KP-N-RT-BM-1
AC   CVCL_1339
SY   KPNRTBM1; KP-N-RT(BM1); RT-BM-1; RT-BM 1; RTBM1; KP-N-RT-BM; KP-N-RTBM; RT-BM; BM1; KP-N-RT; Kyoto Pediatrics-Neuroblastoma-RT-Bone Marrow
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03470963
DR   BioSample; SAMN10987720
DR   cancercelllines; CVCL_1339
DR   Cell_Model_Passport; SIDM00557
DR   CGH-DB; 69-1
DR   CGH-DB; 9079-4
DR   ChEMBL-Cells; CHEMBL3308339
DR   ChEMBL-Targets; CHEMBL2366107
DR   Cosmic; 848926
DR   Cosmic; 924189
DR   Cosmic-CLP; 924189
DR   DepMap; ACH-000345
DR   GDSC; 924189
DR   GEO; GSM887239
DR   GEO; GSM888313
DR   GEO; GSM1670005
DR   IARC_TP53; 27697
DR   JCRB; IFO50432
DR   LiGeA; CCLE_682
DR   PharmacoDB; KPNRTBM1_786_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1339
DR   PubChem_Cell_line; CVCL_1339
DR   Wikidata; Q54900391
RX   CelloPub=CLPUB00582;
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=3731124;
RX   PubMed=10628353;
RX   PubMed=11129446;
RX   PubMed=11501497;
RX   PubMed=12702577;
RX   PubMed=15892104;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=23268333;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 42 hours (PubMed=10628353).
CC   HLA typing: A*24:02,31:01; B*35:03,56:01; C*01:02,03:03 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.43%; Native American=0.27%; East Asian, North=72.99%; East Asian, South=24.04%; South Asian=0%; European, North=0%; European, South=2.27% (PubMed=30894373).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Cosmic-CLP=924189; JCRB=IFO50432; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9,12
ST   D16S539: 10,12
ST   D18S51: 15,17
ST   D19S433: 13
ST   D21S11: 30,31.2
ST   D2S1338: 20
ST   D3S1358: 15,17
ST   D5S818: 10,13
ST   D7S820: 10,11
ST   D8S1179: 12,13
ST   FGA: 20,21
ST   Penta D: 9,12
ST   Penta E: 12,16
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,20
DI   NCIt; C4827; Adrenal gland neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9511 ! KP-N-RT-LN
SX   Female
AG   1Y2M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 37
//
RX   CelloPub=CLPUB00582;
RA   Sugimoto, Tohru
RA   Kuroda, Hiroshi
RA   Yagyu, Shigeki
RA   Gotoh, Takahiro
RA   Osone, Shinya
RA   Tamura, Shinichi
RA   Iehara, Tomoko
RA   Hosoi, Hajime
RT   "Cellular and molecular characteristics of established neuroblastoma
RT   cell lines.";
RL   J. Cancer Res. Therap. Oncol. 7:201.1-201.15(2019).
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele, Carol Jeanne
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=3731124;
RA   Sugimoto, Tohru
RA   Sawada, Tadashi
RA   Matsumura, Takafumi
RA   Kemshead, John T.
RA   Ishii, Takashi
RA   Horii, Yoshihiro
RA   Morioka, Hiroyuki
RA   Morita, Masuji
RA   Reynolds, Charles Patrick
RT   "Identical expression of cell surface membrane antigens on two parent
RT   and eighteen cloned cell lines derived from two different
RT   neuroblastoma metastases of the same patient.";
RL   Cancer Res. 46:4765-4769(1986).
//
RX   PubMed=10628353;
RA   Yasuno, Tetsuya
RA   Matsumura, Takafumi
RA   Shikata, Takuma
RA   Inazawa, Johji
RA   Sakabe, Tomoya
RA   Tsuchida, Shigeki
RA   Takahata, Takenori
RA   Miyairi, Shinichi
RA   Naganuma, Akira
RA   Sawada, Tadashi
RT   "Establishment and characterization of a cisplatin-resistant human
RT   neuroblastoma cell line.";
RL   Anticancer Res. 19:4049-4057(1999).
//
RX   PubMed=11129446; DOI=10.1097/00019606-200012000-00007;
RA   Sugimoto, Tohru
RA   Mine, Hiroshi
RA   Horii, Yoshihiro
RA   Takahashi, Katsuhito
RA   Nagai, Ryozo
RA   Morishita, Ryuichi
RA   Komada, Mihiro
RA   Asada, Yujiro
RA   Sawada, Tadashi
RT   "Neuroblastoma cell lines showing smooth muscle cell phenotypes.";
RL   Diagn. Mol. Pathol. 9:221-228(2000).
//
RX   PubMed=11501497; DOI=10.2739/kurumemedj.48.159;
RA   Ueda, Koichiro
RT   "Detection of the retinoic acid-regulated genes in a RTBM1
RT   neuroblastoma cell line using cDNA microarray.";
RL   Kurume Med. J. 48:159-164(2001).
//
RX   PubMed=12702577;
RA   Saito-Ohara, Fumiko
RA   Imoto, Issei
RA   Inoue, Jun
RA   Hosoi, Hajime
RA   Nakagawara, Akira
RA   Sugimoto, Tohru
RA   Inazawa, Johji
RT   "PPM1D is a potential target for 17q gain in neuroblastoma.";
RL   Cancer Res. 63:1876-1883(2003).
//
RX   PubMed=15892104; DOI=10.1002/gcc.20198;
RA   Mosse, Yael P.
RA   Greshock, Joel
RA   Margolin, Adam A.
RA   Naylor, Tara
RA   Cole, Kristina A.
RA   Khazi, Deepa
RA   Hii, George
RA   Winter, Cynthia
RA   Shahzad, Syed
RA   Asziz, Muhammad Usman
RA   Biegel, Jaclyn A.
RA   Weber, Barbara L.
RA   Maris, John Matthew
RT   "High-resolution detection and mapping of genomic DNA alterations in
RT   neuroblastoma.";
RL   Genes Chromosomes Cancer 43:390-403(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23268333; DOI=10.1016/j.canlet.2012.12.011;
RA   Sugimoto, Tohru
RA   Gotoh, Takahiro
RA   Yagyu, Shigeki
RA   Kuroda, Hiroshi
RA   Iehara, Tomoko
RA   Hosoi, Hajime
RA   Ohta, Sigeru
RA   Ohira, Miki
RA   Nakagawara, Akira
RT   "A MYCN-amplified cell line derived from a long-term event-free
RT   survivor among our sixteen established neuroblastoma cell lines.";
RL   Cancer Lett. 331:115-121(2013).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//