ID   HTC-C3
AC   CVCL_1295
SY   HTC/C3; HTC C3; HTCC3
DR   BTO; BTO_0006211
DR   CLO; CLO_0037152
DR   CLO; CLO_0050946
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN01821636
DR   BioSample; SAMN01821686
DR   BioSample; SAMN03470940
DR   cancercelllines; CVCL_1295
DR   Cell_Model_Passport; SIDM00496
DR   CGH-DB; 58-1
DR   ChEMBL-Cells; CHEMBL3308747
DR   ChEMBL-Targets; CHEMBL1075472
DR   Cosmic; 924151
DR   Cosmic; 2009524
DR   Cosmic; 2054084
DR   Cosmic; 2613249
DR   Cosmic-CLP; 924151
DR   DepMap; ACH-001350
DR   DSMZ; ACC-580
DR   DSMZCellDive; ACC-580
DR   EGA; EGAS00001000978
DR   GDSC; 924151
DR   GEO; GSM1669916
DR   IARC_TP53; 1306
DR   JCRB; FDSC0042
DR   JCRB; JCRB0164
DR   LINCS_LDP; LCL-1689
DR   PharmacoDB; HTCC3_633_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1295
DR   RCB; RCB0452
DR   Wikidata; Q54896604
RX   PubMed=1516062;
RX   PubMed=2196988;
RX   PubMed=9177455;
RX   PubMed=16924234;
RX   PubMed=20164919;
RX   PubMed=23833040;
RX   PubMed=25877200;
RX   PubMed=27397505;
RX   PubMed=30737244;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: ~100 hours (DSMZ=ACC-580); ~2 days (Note=Lot 04162002) (JCRB=JCRB0164).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244; Cosmic-CLP=924151; DepMap=ACH-001350).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Homozygous (PubMed=1516062; PubMed=30737244; Cosmic-CLP=924151; DepMap=ACH-001350).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.77%; Native American=0.3%; East Asian, North=74.17%; East Asian, South=22.11%; South Asian=0.65%; European, North=0.12%; European, South=1.88% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0042; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): Cosmic-CLP=924151; DSMZ=ACC-580; JCRB=JCRB0164; PubMed=25877200; PubMed=30737244; RCB=RCB0452
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 10,12
ST   D16S539: 9,12
ST   D18S51: 14,17
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 17,23
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 21,22
ST   Penta D: 9
ST   Penta E: 11,16
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 14,15
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 44
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa, Inigo
RA   Pozdeyev, Nikita
RA   Korch, Christopher T.
RA   Marlow, Laura A.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RA   Henderson, Ying C.
RA   Lai, Stephen Y.
RA   Clayman, Gary L.
RA   Onoda, Naoyoshi
RA   Tan, Aik-Choon
RA   Garcia-Rendueles, Maria E.R.
RA   Knauf, Jeffrey A.
RA   Haugen, Bryan R.
RA   Fagin, James Alexander
RA   Schweppe, Rebecca E.
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=2196988; DOI=10.1002/1097-0142(19900501)65:9<1971::AID-CNCR2820650916>3.0.CO;2-V;
RA   Enomoto, Tetsuya
RA   Sugawa, Hideo
RA   Inoue, Daisuke
RA   Miyamoto, Masumi
RA   Kosugi, Shinji
RA   Takahashi, Takayuki
RA   Kitamura, Nobuyasu
RA   Yamamoto, Itsuo
RA   Konishi, Junji
RA   Mori, Toru
RA   Imura, Hiroo
RT   "Establishment of a human undifferentiated thyroid cancer cell line
RT   producing several growth factors and cytokines.";
RL   Cancer 65:1971-1979(1990).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=16924234; DOI=10.1038/sj.onc.1209899;
RA   Yu, Wei
RA   Imoto, Issei
RA   Inoue, Jun
RA   Onda, Masahiko
RA   Emi, Mitsuru
RA   Inazawa, Johji
RT   "A novel amplification target, DUSP26, promotes anaplastic thyroid
RT   cancer cell growth by inhibiting p38 MAPK activity.";
RL   Oncogene 26:1178-1187(2007).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa, Inigo
RA   Ganly, Ian
RA   Chan, Timothy A.
RA   Mitsutake, Norisato
RA   Matsuse, Michiko
RA   Ibrahimpasic, Tihana
RA   Ghossein, Ronald A.
RA   Fagin, James Alexander
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=1516062;
RA   Yoshimoto, Katsuhiko
RA   Iwahana, Hiroyuki
RA   Fukuda, Ayumi
RA   Sano, Toshiaki
RA   Saito, Shiro
RA   Itakura, Mitsuo
RT   "Role of p53 mutations in endocrine tumorigenesis: mutation detection
RT   by polymerase chain reaction-single strand conformation
RT   polymorphism.";
RL   Cancer Res. 52:5061-5064(1992).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=9177455; DOI=10.1016/S0304-3835(97)04742-3;
RA   Satake, Shoji
RA   Sugawara, Isamu
RA   Watanabe, M.
RA   Takami, Hiroshi
RT   "Lack of a point mutation of human DNA topoisomerase II in
RT   multidrug-resistant anaplastic thyroid carcinoma cell lines.";
RL   Cancer Lett. 116:33-39(1997).
//