ID   HT-1197
AC   CVCL_1291
SY   HT 1197; HT1197; HT 1197.T
DR   BTO; BTO:0004124
DR   CLO; CLO_0004267
DR   CLO; CLO_0004278
DR   EFO; EFO_0002202
DR   CLDB; cl1734
DR   CLDB; cl7161
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1473
DR   ATCC; CRL-7926
DR   BCRC; 60059
DR   BioGRID_ORCS_Cell_line; 415
DR   BioSample; SAMN03471362
DR   BioSample; SAMN10988033
DR   cancercelllines; CVCL_1291
DR   Cell_Model_Passport; SIDM00676
DR   ChEMBL-Cells; CHEMBL3308506
DR   ChEMBL-Targets; CHEMBL614836
DR   Cosmic; 715772
DR   Cosmic; 760473
DR   Cosmic; 845563
DR   Cosmic; 907065
DR   Cosmic; 925822
DR   Cosmic; 928814
DR   Cosmic; 1285117
DR   Cosmic; 1285988
DR   Cosmic; 1927306
DR   Cosmic; 2037946
DR   Cosmic; 2050443
DR   Cosmic; 2057448
DR   Cosmic; 2444236
DR   Cosmic; 2685944
DR   Cosmic-CLP; 907065
DR   DepMap; ACH-000547
DR   ECACC; 87032403
DR   EGA; EGAS00001000978
DR   ENCODE; ENCBS699THW
DR   ENCODE; ENCBS772EGW
DR   GDSC; 907065
DR   GEO; GSM136229
DR   GEO; GSM142304
DR   GEO; GSM827290
DR   GEO; GSM887138
DR   GEO; GSM888209
DR   GEO; GSM1374559
DR   GEO; GSM1669910
DR   IARC_TP53; 3719
DR   IARC_TP53; 21130
DR   ICLC; HTL04006
DR   IGRhCellID; HT1197
DR   KCLB; 21473
DR   LiGeA; CCLE_192
DR   LINCS_LDP; LCL-1713
DR   PharmacoDB; HT1197_627_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1291
DR   PubChem_Cell_line; CVCL_1291
DR   SKY/M-FISH/CGH; 1463
DR   Wikidata; Q54896502
RX   PubMed=191628;
RX   PubMed=3518877;
RX   PubMed=3708594;
RX   PubMed=6244232;
RX   PubMed=7787250;
RX   PubMed=8873383;
RX   PubMed=11416159;
RX   PubMed=11921286;
RX   PubMed=12068308;
RX   PubMed=15846775;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=23401075;
RX   PubMed=24018021;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=25984343;
RX   PubMed=25997541;
RX   PubMed=27270441;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29732388;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   https://tcpaportal.org/mclp/
WW   https://www.synapse.org/UC25
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Population: Caucasian.
CC   Doubling time: 61 hours (PubMed=3708594); 46 hours (PubMed=25984343).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=12068308).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His365Arg (c.1094A>G); Zygosity=Unspecified (PubMed=7787250).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.12%; East Asian, North=1.86%; East Asian, South=0%; South Asian=0%; European, North=66.24%; European, South=31.77% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7926; true.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
ST   Source(s): ATCC; Cosmic-CLP; ECACC; KCLB; PubMed=11416159; PubMed=27270441
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 12,13
ST   D18S51: 19
ST   D21S11: 31,32.2
ST   D3S1358: 15,18
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 9,13
ST   FGA: 20,23
ST   TH01: 6,9.3
ST   TPOX: 11,12
ST   vWA: 16,18
DI   NCIt; C7899; Recurrent bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 42
//
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//
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//
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RT   of twenty-two human urothelial cell lines.";
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//
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RT   "Human urologic cancer cell lines.";
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//
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//
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RT   deletion inactivate the CDKN2, CDKN2B and MTAP genes.";
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//
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RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
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//
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RT   loci in bladder cancer cell lines.";
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//
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//
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RA   Knowles M.A.;
RT   "Assessment by M-FISH of karyotypic complexity and cytogenetic
RT   evolution in bladder cancer in vitro.";
RL   Genes Chromosomes Cancer 43:315-328(2005).
//
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RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
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//
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RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
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RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
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RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
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RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
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RA   Guo Y.-N., Chekaluk Y., Zhang J.-M., Du J.-Y., Gray N.S., Wu C.-L.,
RA   Kwiatkowski D.J.;
RT   "TSC1 involvement in bladder cancer: diverse effects and therapeutic
RT   implications.";
RL   J. Pathol. 230:17-27(2013).
//
RX   PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052;
RA   Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M.,
RA   van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A.,
RA   Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G.,
RA   Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C.,
RA   Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.;
RT   "Telomerase reverse transcriptase promoter mutations in bladder
RT   cancer: high frequency across stages, detection in urine, and lack of
RT   association with outcome.";
RL   Eur. Urol. 65:360-366(2014).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst C.D., Platt F.M., Knowles M.A.;
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
RX   PubMed=24367658; DOI=10.1371/journal.pone.0084411;
RA   Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H.,
RA   Knowles M.A.;
RT   "Identification of mutations in distinct regions of p85 alpha in
RT   urothelial cancer.";
RL   PLoS ONE 8:E84411-E84411(2013).
//
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RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
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RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
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RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
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RA   Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B.,
RA   Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G.,
RA   Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D.,
RA   Chanock S.J., Valencia A., Real F.X.;
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
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RT   "Molecular analysis of urothelial cancer cell lines for modeling tumor
RT   biology and drug response.";
RL   Oncogene 36:35-46(2017).
//
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RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
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//
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RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
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RT   Encyclopedia.";
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//
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RA   Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K.,
RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
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RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
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RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
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RL   Cancer Cell 40:835-849.e8(2022).
//