ID HGC-27 AC CVCL_1279 SY HGC 27; HGC27 DR BTO; BTO_0004828 DR CLO; CLO_0003739 DR CLO; CLO_0050799 DR EFO; EFO_0006581 DR CLDB; cl1673 DR CLDB; cl1674 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BCRJ; 0310 DR BioGRID_ORCS_Cell_line; 658 DR BioSample; SAMN03472940 DR BioSample; SAMN10987863 DR cancercelllines; CVCL_1279 DR CCRID; 1101HUM-PUMC000279 DR CCRID; 3101HUMTCHu22 DR CCRID; 5301HUM-KCB16001YJ DR Cell_Model_Passport; SIDM00290 DR ChEMBL-Cells; CHEMBL3308741 DR ChEMBL-Targets; CHEMBL1075463 DR CLS; 300436 DR Cosmic; 907055 DR Cosmic; 1001653 DR Cosmic; 1007604 DR Cosmic; 1187274 DR Cosmic; 1518247 DR Cosmic; 1995440 DR Cosmic; 2484952 DR Cosmic; 2807625 DR Cosmic-CLP; 907055 DR DepMap; ACH-000847 DR ECACC; 94042256 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 907055 DR GEO; GSM552358 DR GEO; GSM827366 DR GEO; GSM844558 DR GEO; GSM887081 DR GEO; GSM888151 DR GEO; GSM1374533 DR GEO; GSM1374534 DR GEO; GSM1669881 DR GEO; GSM2983069 DR GEO; GSM2983070 DR GEO; GSM2983071 DR GEO; GSM2983072 DR IARC_TP53; 21370 DR ICLC; HTL95028 DR KCB; KCB 2016001YJ DR LiGeA; CCLE_106 DR LINCS_LDP; LCL-1882 DR PharmacoDB; HGC27_543_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1279 DR PubChem_Cell_line; CVCL_1279 DR RCB; RCB0500 DR Ubigene; YC-C079 DR Wikidata; Q54886004 RX PubMed=136873; RX PubMed=3986962; RX PubMed=11314020; RX PubMed=11416159; RX PubMed=15767549; RX PubMed=15901131; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=24807215; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=34466148; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR45 cancer cell line panel. CC Population: Japanese. CC Doubling time: ~17 hours (Note=At 21th passage) (PubMed=136873). CC HLA typing: A*24:02:24:02; B*55:02,55:02; C*03:03,03:03 (PubMed=26589293). CC HLA typing: A*24:02:01; B*55:02:01; C*03:03:01; DPB1*05:01:01; DQA1*01:01:01; DQB1*05:01:01; DRB1*01:01:01 (CLS=300436). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:882; ATR; Simple; p.Gly2316fs*9 (c.6947delG); Zygosity=Heterozygous (Cosmic-CLP=907055; DepMap=ACH-000847). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (Cosmic-CLP=907055; DepMap=ACH-000847). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (Cosmic-CLP=907055; DepMap=ACH-000847). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=77.61%; East Asian, South=21.46%; South Asian=0.22%; European, North=0%; European, South=0.7% (PubMed=30894373). CC Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. ST Source(s): CCRID; CLS=300436; Cosmic-CLP=907055; ECACC=94042256; PubMed=11416159; PubMed=25877200; RCB=RCB0500 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 10,11 ST D16S539: 10,11 ST D18S51: 16 (PubMed=11416159) ST D18S51: 16,17 (CCRID; CLS=300436; PubMed=25877200) ST D19S433: 14 ST D21S11: 30,33,34 ST D2S1338: 22,24 ST D3S1358: 17 (CLS=300436; PubMed=25877200) ST D3S1358: 17,17.3 (CCRID) ST D5S818: 12 ST D7S820: 11,12,13 ST D8S1179: 7,11,16 (CLS=300436) ST D8S1179: 8.2,10,11,16 (CCRID) ST D8S1179: 11 (PubMed=11416159; PubMed=25877200) ST FGA: 22 ST Penta D: 9,13 ST Penta E: 18 ST TH01: 9 ST TPOX: 8 ST vWA: 14 DI NCIt; C4911; Gastric carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Sex unspecified AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 45 CH CVCL_XB28 ! HGC27-EGFP CH CVCL_XD65 ! HGC27-mCherry-2 CH CVCL_XB29 ! HGC27-tdT CH CVCL_E2Q4 ! HyCyte HGC-27 hKDM6A_p.A694T_c.2080G>A CH CVCL_F1QF ! HyCyte HGC-27 KO-hHKDC1 CH CVCL_F1QG ! HyCyte HGC-27 KO-hLIN28B CH CVCL_F1QH ! HyCyte HGC-27 KO-hPIN1 CH CVCL_F1QI ! HyCyte HGC-27 KO-hZC3H13 CH CVCL_E3HI ! HyCyte HGC-27-Luc CH CVCL_D9W7 ! Ubigene HGC-27 FGFR1 KO CH CVCL_D9W8 ! Ubigene HGC-27 PIN1 KO // RX PubMed=34466148; DOI=10.3892/ol.2021.12996; PMCID=PMC8387854; RA Ikari, Naoki RA Serizawa, Akiko RA Tanji, Etsuko RA Yamamoto, Masakazu RA Furukawa, Toru RT "Analysis of RHOA mutations and their significance in the RT proliferation and transcriptome of digestive tract cancer cells."; RL Oncol. Lett. 22:735.1-735.7(2021). // RX PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760; RA Liu, Jin-Feng RA McCleland, Mark L. RA Stawiski, Eric W. RA Gnad, Florian RA Mayba, Oleg RA Haverty, Peter M. RA Durinck, Steffen RA Chen, Ying-Jiun RA Klijn, Christiaan RA Jhunjhunwala, Suchit RA Lawrence, Michael RA Liu, Han-Bin RA Wan, Yi-Nan RA Chopra, Vivek S. RA Yaylaoglu, Murat Burat RA Yuan, Wen-Lin RA Ha, Connie RA Gilbert, Houston N. RA Reeder, Jens RA Pau, Gregoire RA Stinson, Jeremy RA Stern, Howard M. RA Manning, Gerard RA Wu, Thomas D. RA Neve, Richard M. RA de Sauvage, Frederic J. RA Modrusan, Zora RA Seshagiri, Somasekar RA Firestein, Ron RA Zhang, Ze-Min RT "Integrated exome and transcriptome sequencing reveals ZAK isoform RT usage in gastric cancer."; RL Nat. Commun. 5:3830.1-3830.8(2014). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234; RA Nakatsu, Noriyuki RA Yoshida, Yoko RA Yamazaki, Kanami RA Nakamura, Tomoki RA Dan, Shingo RA Fukui, Yasuhisa RA Yamori, Takao RT "Chemosensitivity profile of cancer cell lines and identification of RT genes determining chemosensitivity by an integrated bioinformatical RT approach using cDNA arrays."; RL Mol. Cancer Ther. 4:399-412(2005). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=136873; DOI=10.18926/AMO/31422; RA Akagi, Tadaatsu RA Kimoto, Tetsuo RT "Human cell line (HGC-27) derived from the metastatic lymph node of RT gastric cancer."; RL Acta Med. Okayama 30:215-219(1976). // RX PubMed=15901131; DOI=10.1016/j.prp.2005.01.002; RA Murai, Yoshihiro RA Hayashi, Shinichi RA Takahashi, Hiroyuki RA Tsuneyama, Koichi RA Takano, Yasuo RT "Correlation between DNA alterations and p53 and p16 protein RT expression in cancer cell lines."; RL Pathol. Res. Pract. 201:109-115(2005). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=11314020; DOI=10.1038/sj.onc.1204160; RA Kataoka, Hiromi RA Miura, Yutaka RA Joh, Takashi RA Seno, Kyoji RA Tada, Toyohiro RA Tamaoki, Taiki RA Nakabayashi, Hidekazu RA Kawaguchi, Makoto RA Asai, Kiyofumi RA Kato, Taiji RA Itoh, Makoto RT "Alpha-fetoprotein producing gastric cancer lacks transcription factor RT ATBF1."; RL Oncogene 20:869-873(2001). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine Hellenga RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=3986962; DOI=10.1093/carcin/6.4.549; RA Watatani, Masahiro RA Ikenaga, Mituo RA Hatanaka, Toshihiro RA Kinuta, Masakatsu RA Takai, Shin-ichiro RA Mori, Takesada RA Kondo, Sohei RT "Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA RT damage in tumor cell strains from Japanese patients and demonstration RT of MNNG hypersensitivity of Mer xenografts in athymic nude mice."; RL Carcinogenesis 6:549-553(1985). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //