ID HCC2157 AC CVCL_1261 SY Hamon Cancer Center 2157 DR CLO; CLO_0003650 DR EFO; EFO_0001177 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ArrayExpress; E-TABM-157 DR ATCC; CRL-2340 DR BioSample; SAMN03470829 DR BioSample; SAMN03471823 DR BioSample; SAMN10987607 DR cancercelllines; CVCL_1261 DR Cell_Model_Passport; SIDM00774 DR ChEMBL-Cells; CHEMBL3308891 DR ChEMBL-Targets; CHEMBL2366126 DR Cosmic; 749715 DR Cosmic; 904370 DR Cosmic; 1018472 DR Cosmic; 1235084 DR Cosmic; 1430341 DR Cosmic; 1460236 DR Cosmic; 1473033 DR Cosmic; 1518114 DR Cosmic; 1603210 DR Cosmic; 1995430 DR Cosmic-CLP; 749715 DR DepMap; ACH-000691 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 749715 DR GEO; GSM350525 DR GEO; GSM783938 DR GEO; GSM847343 DR GEO; GSM847485 DR GEO; GSM887048 DR GEO; GSM888118 DR GEO; GSM1669854 DR IARC_TP53; 21364 DR IARC_TP53; 22815 DR IARC_TP53; 30204 DR IGRhCellID; HCC2157 DR LiGeA; CCLE_003 DR LINCS_HMS; 50581 DR LINCS_LDP; LCL-1327 DR PharmacoDB; HCC2157_488_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1261 DR PubChem_Cell_line; CVCL_1261 DR Wikidata; Q54881634 RX PubMed=9833771; RX PubMed=9865903; RX PubMed=11314036; RX PubMed=16959974; RX PubMed=17157791; RX PubMed=17932254; RX PubMed=19582160; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=21778573; RX PubMed=22460905; RX PubMed=24094812; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; WW Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/ WW Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255 WW Provider; UT Southwestern; -; https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf CC Group: Triple negative breast cancer (TNBC) cell line. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: ICBP43 breast cancer cell line panel. CC Part of: JWGray breast cancer cell line panel. CC Population: African American. CC HLA typing: A*02:02,30:01; B*41:02,42:01; C*17:01,17:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (Cosmic-CLP=749715). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; CNV analysis. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=87.84%; Native American=0%; East Asian, North=4.38%; East Asian, South=0%; South Asian=0%; European, North=0%; European, South=7.78% (PubMed=30894373). CC Miscellaneous: Direct author submission of STR profile from Girard, Luc & Gazdar, Adi F. CC Derived from site: In situ; Breast; UBERON=UBERON_0000310. ST Source(s): ATCC=CRL-2340; Cosmic-CLP=749715; Direct_author_submission; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 10 ST D10S1248: 11,15 ST D12S391: 18 ST D13S317: 12 ST D16S539: 11 (ATCC=CRL-2340; Cosmic-CLP=749715) ST D16S539: 11,12 (Direct_author_submission; PubMed=25877200) ST D18S51: 15 ST D19S433: 13 ST D1S1656: 16.3 ST D21S11: 28,29 ST D22S1045: 11,15 ST D2S1338: 21 ST D2S441: 11,12 ST D3S1358: 16,18 ST D5S818: 13 ST D7S820: 10,12 ST D8S1179: 13 ST FGA: 21 ST Penta D: 8,10 ST Penta E: 12,15 ST TH01: 8,9 ST TPOX: 9,11 ST vWA: 14,18 DI NCIt; C4017; Breast ductal carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_1262 ! HCC2157 BL SX Female AG 48Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 46 // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=11314036; DOI=10.1038/sj.onc.1204211; RA Forgacs, Eva RA Wren, Jonathan D. RA Kamibayashi, Craig RA Kondo, Masashi RA Xu, Xie L. RA Markowitz, Sanford David RA Tomlinson, Gail E. RA Muller, Carolyn Y. RA Gazdar, Adi F. RA Garner, Harold Ray RA Minna, John D. RT "Searching for microsatellite mutations in coding regions in lung, RT breast, ovarian and colorectal cancers."; RL Oncogene 20:1005-1009(2001). // RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoblom, Tobias RA Jones, Sian RA Wood, Laura DeLong RA Parsons, D. Williams RA Lin, Jimmy RA Barber, Thomas D. RA Mandelker, Diana RA Leary, Rebecca J. RA Ptak, Janine RA Silliman, Natalie RA Szabo, Steve RA Buckhaults, Phillip RA Farrell, Christopher RA Meeh, Paul RA Markowitz, Sanford David RA Willis, Joseph E. RA Dawson, Dawn RA Willson, James K.V. RA Gazdar, Adi F. RA Hartigan, James RA Wu, Leo RA Liu, Chang-Sheng RA Parmigiani, Giovanni RA Park, Ben Ho RA Bachman, Kurtis E. RA Papadopoulos, Nickolas RA Vogelstein, Bert RA Kinzler, Kenneth Wayne RA Velculescu, Victor E. RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890; RA Chavez, Kathryn J. RA Garimella, Sireesha Venkata RA Lipkowitz, Stanley RT "Triple negative breast cancer cell lines: one tool in the search for RT better treatment of triple negative breast cancer."; RL Breast Dis. 32:35-48(2010). // RX PubMed=9833771; DOI=10.1002/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L; RA Gazdar, Adi F. RA Kurvari, Venkatesh RA Virmani, Arvind K. RA Gollahon, Lauren S. RA Sakaguchi, Masahiro RA Westerfield, Max RA Kodagoda, Dulmini R. RA Stasny, Victor RA Cunningham, H. Thomas RA Wistuba, Ignacio Ivan RA Tomlinson, Gail E. RA Tonk, Vijay RA Ashfaq, Raheela RA Leitch, A. Marilyn RA Minna, John D. RA Shay, Jerry W. RT "Characterization of paired tumor and non-tumor cell lines established RT from patients with breast cancer."; RL Int. J. Cancer 78:766-774(1998). // RX PubMed=17932254; DOI=10.1126/science.1145720; RA Wood, Laura DeLong RA Parsons, D. Williams RA Jones, Sian RA Lin, Jimmy RA Sjoblom, Tobias RA Leary, Rebecca J. RA Shen, Dong RA Boca, Simina Maria RA Barber, Thomas D. RA Ptak, Janine RA Silliman, Natalie RA Szabo, Steve RA Dezso, Zoltan RA Ustyanksky, Vadim RA Nikolskaya, Tatiana RA Nikolsky, Yuri RA Karchin, Rachel RA Wilson, Paul A. RA Kaminker, Joshua S. RA Zhang, Ze-Min RA Croshaw, Randal RA Willis, Joseph E. RA Dawson, Dawn RA Shipitsin, Michail RA Willson, James K.V. RA Sukumar, Saraswati RA Polyak, Kornelia RA Park, Ben Ho RA Pethiyagoda, Charit L. RA Pant, P.V. Krishna RA Ballinger, Dennis G. RA Sparks, Andrew B. RA Hartigan, James RA Smith, Douglas R. RA Suh, Erick RA Papadopoulos, Nickolas RA Buckhaults, Phillip RA Markowitz, Sanford David RA Parmigiani, Giovanni RA Kinzler, Kenneth Wayne RA Velculescu, Victor E. RA Vogelstein, Bert RT "The genomic landscapes of human breast and colorectal cancers."; RL Science 318:1108-1113(2007). // RX PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310; RA Timmerman, Luika A. RA Holton, Thomas RA Yuneva, Mariia RA Louie, Raymond J. RA Padro, Merce RA Daemen, Anneleen RA Hu, Min RA Chan, Denise A. RA Ethier, Stephen P. RA van 't Veer, Laura J. RA Polyak, Kornelia RA McCormick, Frank RA Gray, Joe W. RT "Glutamine sensitivity analysis identifies the xCT antiporter as a RT common triple-negative breast tumor therapeutic target."; RL Cancer Cell 24:450-465(2013). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=9865903; RA Wistuba, Ignacio Ivan RA Behrens, Carmen RA Milchgrub, Sara RA Syed, Salahuddin RA Ahmadian, Mohsen RA Virmani, Arvind K. RA Kurvari, Venkatesh RA Cunningham, Thomas H. RA Ashfaq, Raheela RA Minna, John D. RA Gazdar, Adi F. RT "Comparison of features of human breast cancer cell lines and their RT corresponding tumors."; RL Clin. Cancer Res. 4:2931-2938(1998). // RX PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521; RA Neve, Richard M. RA Chin, Koei RA Fridlyand, Jane RA Yeh, Jennifer RA Baehner, Frederick L. RA Fevr, Tea RA Clark, Laura RA Bayani, Nora RA Coppe, Jean-Philippe RA Tong, Frances RA Speed, Terry RA Spellman, Paul T. RA DeVries, Sandy RA Lapuk, Anna RA Wang, Nick J. RA Kuo, Wen-Lin RA Stilwell, Jackie L. RA Pinkel, Daniel RA Albertson, Donna G. RA Waldman, Frederic M. RA McCormick, Frank RA Dickson, Robert Brent RA Johnson, Michael D. RA Lippman, Marc E. RA Ethier, Stephen P. RA Gazdar, Adi F. RA Gray, Joe W. RT "A collection of breast cancer cell lines for the study of RT functionally distinct cancer subtypes."; RL Cancer Cell 10:515-527(2006). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084; RA Kao, Jessica RA Salari, Keyan RA Bocanegra, Melanie RA Choi, Yoon-La RA Girard, Luc RA Gandhi, Jeet RA Kwei, Kevin A. RA Hernandez-Boussard, Tina RA Wang, Pei RA Gazdar, Adi F. RA Minna, John D. RA Pollack, Jonathan R. RT "Molecular profiling of breast cancer cell lines defines relevant RT tumor models and provides a resource for cancer gene discovery."; RL PLoS ONE 4:e6146.1-e6146.16(2009). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //