ID   H9
AC   CVCL_1240
SY   HT clone H9; HT(H9); H 9; H-9
DR   BTO; BTO_0001944
DR   CLO; CLO_0003581
DR   CLO; CLO_0003612
DR   EFO; EFO_0003045
DR   CLDB; cl1556
DR   CLDB; cl1557
DR   CLDB; cl7167
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-176
DR   BEI_Resources; ARP-87
DR   BioSample; SAMN03472731
DR   cancercelllines; CVCL_1240
DR   CCRID; 4201MOU-CCTCC00031
DR   CCTCC; GDC0031
DR   Cell_Model_Passport; SIDM01251
DR   ChEMBL-Cells; CHEMBL3308402
DR   ChEMBL-Targets; CHEMBL614806
DR   CLS; 300460
DR   Cosmic; 687842
DR   Cosmic; 907043
DR   Cosmic; 933542
DR   Cosmic; 2301568
DR   Cosmic; 2668295
DR   Cosmic-CLP; 907043
DR   DepMap; ACH-002240
DR   ECACC; 85050301
DR   EGA; EGAS00001000978
DR   GDSC; 907043
DR   GEO; GSM1669836
DR   IARC_TP53; 21356
DR   ICLC; HTL05006
DR   IZSLER; BS TCL 19
DR   KCB; KCB 200418YJ
DR   KCLB; 30176
DR   LINCS_LDP; LCL-1144
DR   Lonza; 910
DR   PharmacoDB; H9_439_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1240
DR   TOKU-E; 3613
DR   Wikidata; Q54872230
RX   PubMed=1460674;
RX   PubMed=2193399;
RX   PubMed=2567177;
RX   PubMed=6151082;
RX   PubMed=7707540;
RX   PubMed=8127147;
RX   PubMed=8320746;
RX   PubMed=8641406;
RX   PubMed=17170727;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; -; -; https://www.bmj.com/rapid-response/2011/10/30/cell-lines-hut102-and-hut78
WW   Provider; NIBSC; 0001; http://www.nibsc.org/Default.aspx?pageid=597&id=0001&theme=default
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Virology: Permissive for HIV-1 replication. Is accordingly used to isolate and propagate HIV-1 from the blood of patients with AIDS.
CC   HLA typing: DRB1*04:01 (PubMed=7707540).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:7208; MPDZ; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP=907043; DepMap=ACH-002240).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (Cosmic-CLP=907043; DepMap=ACH-002240).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=4.91%; Native American=1.41%; East Asian, North=5.59%; East Asian, South=0%; South Asian=0%; European, North=61.37%; European, South=26.72% (PubMed=30894373).
CC   Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
CC   Discontinued: IZSLER; BS TCL 19; probable.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC=HTB-176; CLS=300460; Cosmic-CLP=907043; ECACC=85050301; KCLB=30176
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D12S391: 18,23
ST   D13S317: 8,12
ST   D16S539: 11,12
ST   D18S51: 18
ST   D19S433: 14
ST   D21S11: 30
ST   D2S1338: 20,25
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D6S1043: 12
ST   D7S820: 8,11
ST   D8S1179: 12,14
ST   FGA: 21,25
ST   Penta D: 9
ST   Penta E: 13,15
ST   TH01: 8,9
ST   TPOX: 8,9
ST   vWA: 14,15
DI   NCIt; C3366; Sezary syndrome
DI   ORDO; Orphanet_3162; Sezary syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0337 ! HuT 78
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 41
CH   CVCL_X680 ! H9/HIV-2MVP-11971
CH   CVCL_X681 ! H9/HIV-2MVP-15132
CH   CVCL_3514 ! H9/HTLV-IIIB
CH   CVCL_X621 ! H9/HTLV-IIICC
CH   CVCL_X620 ! H9/HTLV-IIIMN
CH   CVCL_X619 ! H9/HTLV-IIIRF
CH   CVCL_E3D8 ! H9/R7hyg
CH   CVCL_E3D9 ! H9/R7neo
CH   CVCL_X610 ! H9/SIVmac186
CH   CVCL_D536 ! H938
CH   CVCL_U264 ! RH9
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=6151082; DOI=10.1016/S0140-6736(84)91666-0;
RA   Popovic, Mikulas
RA   Read-Connole, Elizabeth Lee
RA   Gallo, Robert Charles
RT   "T4 positive human neoplastic cell lines susceptible to and permissive
RT   for HTLV-III.";
RL   Lancet 324:1472-1473(1984).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x;
RA   Borgonovo-Brandter, Laura
RA   Heyman, Mats
RA   Rasool, Omid
RA   Liu, Yie
RA   Grander, Dan
RA   Einhorn, Stefan
RT   "p16INK4/p15INK4B gene inactivation is a frequent event in malignant
RT   T-cell lines.";
RL   Eur. J. Haematol. 56:313-318(1996).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=2567177; DOI=10.1089/aid.1989.5.253;
RA   Mann, Dean L.
RA   O'Brien, Stephen James
RA   Gilbert, Dennis A.
RA   Reid, Yvonne A.
RA   Popovic, Mikulas
RA   Read-Connole, Elizabeth Lee
RA   Gallo, Robert Charles
RA   Gazdar, Adi F.
RT   "Origin of the HIV-susceptible human CD4+ cell line H9.";
RL   AIDS Res. Hum. Retroviruses 5:253-255(1989).
//
RX   PubMed=8127147;
RA   Heyman, Mats
RA   Grander, Dan
RA   Brondum-Nielsen, Karen
RA   Cederblad, Britta
RA   Liu, Yie
RA   Xu, Bo
RA   Einhorn, Stefan
RT   "Interferon system defects in malignant T-cells.";
RL   Leukemia 8:425-434(1994).
//
RX   PubMed=17170727; DOI=10.1038/sj.leu.2404486;
RA   Sandberg, Yorick
RA   Verhaaf, Brenda
RA   van Gastel-Mol, Ellen J.
RA   Wolvers-Tettero, Ingrid L.M.
RA   De Vos, John
RA   MacLeod, Roderick A.F.
RA   Noordzij, Jeroen G.
RA   Dik, Willem A.
RA   van Dongen, Jacobus Johannes Maria
RA   Langerak, Anton W.
RT   "Human T-cell lines with well-defined T-cell receptor gene
RT   rearrangements as controls for the BIOMED-2 multiplex polymerase chain
RT   reaction tubes.";
RL   Leukemia 21:230-237(2007).
//
RX   PubMed=7707540; DOI=10.1128/JVI.69.5.3117-3124.1995; PMCID=PMC189013;
RA   Arthur, Larry O.
RA   Bess, Julian W. Jr.
RA   Urban, Robert G.
RA   Strominger, Jack Leonard
RA   Morton, William R.
RA   Mann, Dean L.
RA   Henderson, Louis E.
RA   Benveniste, Raoul E.
RT   "Macaques immunized with HLA-DR are protected from challenge with
RT   simian immunodeficiency virus.";
RL   J. Virol. 69:3117-3124(1995).
//
RX   PubMed=8320746; DOI=10.1093/jnci/85.14.1168;
RA   Bunn, Paul A. Jr.
RA   Whang-Peng, Jacqueline
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Carney, Desmond Niall
RT   "Karyotypic derivation of H9 cell line.";
RL   J. Natl. Cancer Inst. 85:1168-1169(1993).
//
RX   PubMed=1460674; DOI=10.1093/jnci/84.24.1922;
RA   Chen, Tchaw-Ren
RT   "Karyotypic derivation of H9 cell line expressing human
RT   immunodeficiency virus susceptibility.";
RL   J. Natl. Cancer Inst. 84:1922-1926(1992).
//
RX   PubMed=2193399; DOI=10.1126/science.2193399;
RA   Rubinstein, Eric
RT   "The untold story of HUT78.";
RL   Science 248:1499-1507(1990).
//