ID EW-22 AC CVCL_1214 SY EW22; IARC-EW-22 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 882 DR cancercelllines; CVCL_1214 DR Cell_Model_Passport; SIDM00196 DR ChEMBL-Cells; CHEMBL3308196 DR ChEMBL-Targets; CHEMBL2366162 DR Cosmic; 684068 DR Cosmic; 949167 DR Cosmic; 1995403 DR Cosmic; 2250461 DR Cosmic-CLP; 949167 DR DepMap; ACH-002116 DR EGA; EGAS00001000978 DR GDSC; 949167 DR GEO; GSM1669787 DR GEO; GSM5359652 DR GEO; GSM5359653 DR GEO; GSM5359654 DR GEO; GSM5359655 DR GEO; GSM5359656 DR GEO; GSM5359657 DR GEO; GSM5362900 DR GEO; GSM5362903 DR GEO; GSM5362906 DR GEO; GSM5362907 DR GEO; GSM5362908 DR GEO; GSM5362909 DR GEO; GSM5363956 DR GEO; GSM5363957 DR GEO; GSM5363958 DR GEO; GSM5363959 DR GEO; GSM5363960 DR IARC_TP53; 27167 DR PharmacoDB; EW22_356_2019 DR PRIDE; PXD030304 DR PubChem_Cell_line; CVCL_1214 DR Wikidata; Q54832999 RX DOI=10.5282/edoc.27750; RX PubMed=20164919; RX PubMed=25223734; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=35839778; RX PubMed=36476851; WW Info; ESCLA; -; https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=about_dscope CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Ewing Sarcoma Cell Line Atlas (ESCLA). CC Population: Caucasian. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=36476851). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=25223734). CC Omics: Genomics; ChIP-seq; FLI1. CC Omics: Genomics; ChIP-seq; H3K27ac. CC Omics: Genomics; ChIP-seq; H3K27me3. CC Omics: Genomics; ChIP-seq; H3K4me3. CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.31%; Native American=0%; East Asian, North=0%; East Asian, South=0%; South Asian=1.44%; European, North=60.63%; European, South=37.61% (PubMed=30894373). ST Source(s): Cosmic-CLP=949167 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 12 ST D16S539: 13 ST D5S818: 11 ST D7S820: 10,11 ST TH01: 6 ST TPOX: 9,11 ST vWA: 17 DI NCIt; C4817; Ewing sarcoma DI ORDO; Orphanet_319; Ewing sarcoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 32 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=36476851; DOI=10.1016/j.celrep.2022.111761; PMCID=PMC10333306; RA Orth, Martin Franz RA Surdez, Didier RA Faehling, Tobias RA Ehlers, Anna C. RA Marchetto, Aruna RA Grossetete-Lalami, Sandrine RA Volckmann, Richard RA Zwijnenburg, Danny A. RA Gerke, Julia Sophie RA Zaidi, Sakina RA Alonso, Javier RA Sastre, Ana RA Baulande, Sylvain RA Sill, Martin RA Cidre-Aranaz, Florencia RA Ohmura, Shunya RA Kirchner, Thomas RA Hauck, Stefanie M. RA Reischl, Eva RA Gymrek, Melissa RA Pfister, Stefan Michael RA Strauch, Konstantin RA Koster, Jan RA Delattre, Olivier RA Grunewald, Thomas Georg Philipp RT "Systematic multi-omics cell line profiling uncovers principles of RT Ewing sarcoma fusion oncogene-mediated gene regulation."; RL Cell Rep. 41:111761.1-111761.28(2022). // RX DOI=10.5282/edoc.27750; RA Orth, Martin Franz RT "Systematic multi-omics profiling of Ewing sarcoma cell lines."; RL Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany. // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622; PMCID=PMC4264969; RA Tirode, Franck RA Surdez, Didier RA Ma, Xiao-Tu RA Parker, Matthew RA Le Deley, Marie-Cecile RA Bahrami, Armita RA Zhang, Zhao-Jie RA Lapouble, Eve RA Grossetete-Lalami, Sandrine RA Rusch, Michael RA Reynaud, Stephanie RA Rio-Frio, Thomas RA Hedlund, Erin RA Wu, Gang RA Chen, Xiang RA Pierron, Gaelle RA Oberlin, Odile RA Zaidi, Sakina RA Lemmon, Gordon RA Gupta, Pankaj RA Vadodaria, Bhavin RA Easton, John RA Gut, Marta RA Ding, Li RA Mardis, Elaine R. RA Wilson, Richard K. RA Shurtleff, Sheila RA Laurence, Valerie RA Michon, Jean RA Marec-Berard, Perrine RA Gut, Ivo G. RA Downing, James R. RA Dyer, Michael Anthony RA Zhang, Jing-Hui RA Delattre, Olivier RG International Cancer Genome Consortium; RG St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project; RT "Genomic landscape of Ewing sarcoma defines an aggressive subtype with RT co-association of STAG2 and TP53 mutations."; RL Cancer Discov. 4:1342-1353(2014). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). //