ID   EW-18
AC   CVCL_1213
SY   EW18; IARC-EW-18
DR   CLO; CLO_0009870
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   cancercelllines; CVCL_1213
DR   Cell_Model_Passport; SIDM00197
DR   ChEMBL-Cells; CHEMBL3308832
DR   ChEMBL-Targets; CHEMBL2366097
DR   Cosmic; 684066
DR   Cosmic; 949164
DR   Cosmic; 1081697
DR   Cosmic; 1995402
DR   Cosmic; 2250476
DR   Cosmic-CLP; 949164
DR   DepMap; ACH-002115
DR   EGA; EGAS00001000978
DR   GDSC; 949164
DR   GEO; GSM1669786
DR   IARC_TP53; 27166
DR   LINCS_LDP; LCL-1450
DR   PharmacoDB; EW18_355_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1213
DR   Wikidata; Q54832995
RX   DOI=10.5282/edoc.27750;
RX   PubMed=20164919;
RX   PubMed=23637631;
RX   PubMed=25223734;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (PubMed=23637631).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=25223734).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.97%; East Asian, North=0.41%; East Asian, South=0%; South Asian=0.22%; European, North=68.25%; European, South=30.15% (PubMed=30894373).
ST   Source(s): Cosmic-CLP=949164
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 10,13
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 7,12
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=23637631; DOI=10.1371/journal.pgen.1003464; PMCID=PMC3636093;
RA   Giacomini, Craig P.
RA   Sun, Steven
RA   Varma, Sushama
RA   Shain, Alan Hunter
RA   Giacomini, Marilyn M.
RA   Balagtas, Jay Michael S.
RA   Sweeney, Robert T.
RA   Lai, Everett
RA   Del Vecchio, Catherine A.
RA   Forster, Andrew D.
RA   Clarke, Nicole
RA   Montgomery, Kelli D.
RA   Zhu, Shirley
RA   Wong, Albert J.
RA   van de Rijn, Matt
RA   West, Robert B.
RA   Pollack, Jonathan R.
RT   "Breakpoint analysis of transcriptional and genomic profiles uncovers
RT   novel gene fusions spanning multiple human cancer types.";
RL   PLoS Genet. 9:e1003464.1-e1003464.19(2013).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622; PMCID=PMC4264969;
RA   Tirode, Franck
RA   Surdez, Didier
RA   Ma, Xiao-Tu
RA   Parker, Matthew
RA   Le Deley, Marie-Cecile
RA   Bahrami, Armita
RA   Zhang, Zhao-Jie
RA   Lapouble, Eve
RA   Grossetete-Lalami, Sandrine
RA   Rusch, Michael
RA   Reynaud, Stephanie
RA   Rio-Frio, Thomas
RA   Hedlund, Erin
RA   Wu, Gang
RA   Chen, Xiang
RA   Pierron, Gaelle
RA   Oberlin, Odile
RA   Zaidi, Sakina
RA   Lemmon, Gordon
RA   Gupta, Pankaj
RA   Vadodaria, Bhavin
RA   Easton, John
RA   Gut, Marta
RA   Ding, Li
RA   Mardis, Elaine R.
RA   Wilson, Richard K.
RA   Shurtleff, Sheila
RA   Laurence, Valerie
RA   Michon, Jean
RA   Marec-Berard, Perrine
RA   Gut, Ivo G.
RA   Downing, James R.
RA   Dyer, Michael Anthony
RA   Zhang, Jing-Hui
RA   Delattre, Olivier
RG   International Cancer Genome Consortium;
RG   St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project;
RT   "Genomic landscape of Ewing sarcoma defines an aggressive subtype with
RT   co-association of STAG2 and TP53 mutations.";
RL   Cancer Discov. 4:1342-1353(2014).
//
RX   DOI=10.5282/edoc.27750;
RA   Orth, Martin Franz
RT   "Systematic multi-omics profiling of Ewing sarcoma cell lines.";
RL   Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//