ID EFO-27 AC CVCL_1192 SY EFO 27; EFO27 DR BTO; BTO_0002033 DR CLO; CLO_0002893 DR EFO; EFO_0006571 DR CLDB; cl1143 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 436 DR BioSample; SAMN03473290 DR BioSample; SAMN03473370 DR BioSample; SAMN10988215 DR cancercelllines; CVCL_1192 DR Cell_Model_Passport; SIDM01051 DR ChEMBL-Cells; CHEMBL3308134 DR ChEMBL-Targets; CHEMBL1075441 DR Cosmic; 906852 DR Cosmic; 1305326 DR Cosmic; 1707565 DR Cosmic-CLP; 906852 DR DepMap; ACH-000936 DR DSMZ; ACC-191 DR DSMZCellDive; ACC-191 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 906852 DR GEO; GSM659375 DR GEO; GSM887001 DR GEO; GSM888070 DR GEO; GSM1340579 DR GEO; GSM1669757 DR IARC_TP53; 21323 DR LiGeA; CCLE_238 DR LINCS_LDP; LCL-1521 DR PharmacoDB; EFO27_326_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1192 DR PubChem_Cell_line; CVCL_1192 DR Wikidata; Q54832067 RX PubMed=3476184; RX PubMed=6405069; RX PubMed=12661003; RX PubMed=20164919; RX PubMed=22460905; RX PubMed=23415752; RX PubMed=23839242; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30485824; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Doubling time: 29 hours (PubMed=25984343); ~50-80 hours (DSMZ=ACC-191); 26.68 hours (JWGray panel). CC HLA typing: A*02:01,03:01; B*35:01,40:01; C*03:04,04:01 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-high) (PubMed=12661003; PubMed=31068700; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (Cosmic-CLP=906852; DepMap=ACH-000936). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Heterozygous (Cosmic-CLP=906852; DepMap=ACH-000936). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.18%; Native American=0%; East Asian, North=1.36%; East Asian, South=0%; South Asian=0%; European, North=70.88%; European, South=27.58% (PubMed=30894373). CC Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. ST Source(s): Cosmic-CLP=906852; DSMZ=ACC-191; PubMed=25877200; PubMed=30485824 ST Amelogenin: X ST CSF1PO: 9,10,13,14 ST D13S317: 12,13 ST D16S539: 11,13 ST D18S51: 12,18 ST D19S433: 13,14 ST D21S11: 27,30 (DSMZ=ACC-191; PubMed=25877200) ST D21S11: 27,30,31 (PubMed=30485824) ST D2S1338: 22,25 ST D3S1358: 14,17 ST D5S818: 11,12 ST D7S820: 8,10 ST D8S1179: 13 (DSMZ=ACC-191) ST D8S1179: 13,15 (PubMed=25877200) ST FGA: 23,26 ST Penta D: 9 ST Penta E: 7,10 ST TH01: 6,8 ST TPOX: 8 ST vWA: 13,18 DI NCIt; C5243; Ovarian mucinous adenocarcinoma DI ORDO; Orphanet_398961; Mucinous adenocarcinoma of ovary OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 36Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 CH CVCL_RS28 ! EFO-27rCDDP2000 // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=6405069; DOI=10.1093/jnci/70.5.839; RA Simon, Wolfgang E. RA Albrecht, Michael RA Hansel, Marianne RA Dietel, Manfred RA Holzel, Fritz RT "Cell lines derived from human ovarian carcinomas: growth stimulation RT by gonadotropic and steroid hormones."; RL J. Natl. Cancer Inst. 70:839-845(1983). // RX PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945; RA Papp, Eniko RA Hallberg, Dorothy RA Konecny, Gottfried E. RA Bruhm, Daniel C. RA Adleff, Vilmos RA Noe, Michael RA Kagiampakis, Ioannis RA Palsgrove, Doreen RA Conklin, Dylan RA Kinose, Yasuto RA White, James R. RA Press, Michael Frederick RA Drapkin, Ronny I. RA Easwaran, Hariharan RA Baylin, Stephen Bruce RA Slamon, Dennis Joseph RA Velculescu, Victor E. RA Scharpf, Robert B. RT "Integrated genomic, epigenomic, and expression analyses of ovarian RT cancer cell lines."; RL Cell Rep. 25:2617-2633(2018). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=3476184; DOI=10.1016/0165-4608(87)90206-8; RA Kunzmann, Regina RA Holzel, Fritz RT "Karyotype alterations in human ovarian carcinoma cells during long-term RT cultivation and nude mouse passage."; RL Cancer Genet. Cytogenet. 28:201-212(1987). // RX PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023; RA Stordal, Britta RA Timms, Kirsten RA Farrelly, Angela RA Gallagher, Danielle RA Busschots, Steven RA Renaud, Mickael RA Thery, Julien RA Williams, Deborah RA Potter, Jennifer RA Tran, Thanh RA Korpanty, Greg RA Cremona, Mattia RA Carey, Mark S. RA Li, Jie RA Li, Yang RA Aslan, Ozlem RA O'Leary, John J. RA Mills, Gordon B. RA Hennessy, Bryan T. RT "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one RT functionally deleterious BRCA1 mutation."; RL Mol. 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RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866; RA Domcke, Silvia RA Sinha, Rileen RA Levine, Douglas A. RA Sander, Chris RA Schultz, Nikolaus RT "Evaluating cell lines as tumour models by comparison of genomic RT profiles."; RL Nat. Commun. 4:2126.1-2126.10(2013). // RX PubMed=12661003; DOI=10.1002/gcc.10196; RA Seitz, Susanne RA Wassmuth, Peter RA Plaschke, Jens RA Schackert, Hans Konrad RA Karsten, Uwe RA Santibanez-Koref, Mauro F. RA Schlag, Peter Michael RA Scherneck, Siegfried RT "Identification of microsatellite instability and mismatch repair gene RT mutations in breast cancer cell lines."; RL Genes Chromosomes Cancer 37:29-35(2003). //