ID EC-GI-10 AC CVCL_1187 SY ECGI10; EC-GI DR CLO; CLO_0051378 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 862 DR BioSample; SAMN03472227 DR BioSample; SAMN10987728 DR cancercelllines; CVCL_1187 DR Cell_Model_Passport; SIDM00278 DR ChEMBL-Cells; CHEMBL3308289 DR ChEMBL-Targets; CHEMBL2366240 DR Cosmic; 753555 DR Cosmic-CLP; 753555 DR DepMap; ACH-000305 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10463-106H4 DR GDSC; 753555 DR GEO; GSM886996 DR GEO; GSM888065 DR GEO; GSM1669753 DR IARC_TP53; 21317 DR LiGeA; CCLE_378 DR LINCS_LDP; LCL-1151 DR PharmacoDB; ECGI10_316_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1187 DR PubChem_Cell_line; CVCL_1187 DR RCB; RCB0774 DR Wikidata; Q54831834 RX PubMed=2824416; RX PubMed=3261732; RX PubMed=11416159; RX PubMed=20164919; RX PubMed=22460905; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Characteristics: Established from a mouse xenograft. CC Doubling time: ~31 hours (PubMed=2824416). CC HLA typing: A*24:02,24:02; B*52:01,52:01; C*12:02,12:02; DQB1*03:02,03:02; DRB1*10:01,11:30 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Cys (c.701A>G); ClinVar=VCV000127820; Zygosity=Heterozygous (Cosmic-CLP=753555; DepMap=ACH-000305). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Heterozygous (Cosmic-CLP=753555; DepMap=ACH-000305). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.68%; Native American=0%; East Asian, North=89.75%; East Asian, South=5.81%; South Asian=0.73%; European, North=0%; European, South=1.02% (PubMed=30894373). CC Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. ST Source(s): Cosmic-CLP=753555; PubMed=11416159; RCB=RCB0774 ST Amelogenin: X,Y ST CSF1PO: 10,11 ST D13S317: 11 ST D16S539: 11,12 ST D18S51: 19 ST D21S11: 31 ST D5S818: 11 ST D7S820: 8,11 ST D8S1179: 9,13 ST FGA: 21,24 ST TH01: 7,9 ST TPOX: 11 ST vWA: 16,18 DI NCIt; C4024; Esophageal squamous cell carcinoma DI ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 65Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 // RX PubMed=2824416; DOI=10.20772/cancersci1985.78.10_1044; RA Sato, Kanji RA Kasono, Keizo RA Ohba, Yoshito RA Yashiro, Toru RA Fujii, Yuko RA Yoshida, Mitsuaki A. RA Tsushima, Toshio RA Shizume, Kazuo RT "Establishment of a parathyroid hormone-like factor-producing RT esophageal carcinoma cell line (EC-GI)."; RL Jpn. J. Cancer Res. 78:1044-1048(1987). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. 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RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. 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RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine Hellenga RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. 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