ID DoHH2 AC CVCL_1179 SY DOHH2; DoHH-2; DOHH-2 DR CLO; CLO_0002805 DR CLO; CLO_0037050 DR EFO; EFO_0002167 DR CLDB; cl1086 DR CLDB; cl4974 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR BioSample; SAMN03472093 DR BioSample; SAMN10988489 DR cancercelllines; CVCL_1179 DR Cell_Model_Passport; SIDM00981 DR ChEMBL-Cells; CHEMBL3308537 DR ChEMBL-Targets; CHEMBL2366181 DR Cosmic; 906842 DR Cosmic; 1086332 DR Cosmic; 1629929 DR Cosmic; 1995387 DR Cosmic; 2297004 DR Cosmic; 2437317 DR Cosmic-CLP; 906842 DR DepMap; ACH-000056 DR DSMZ; ACC-47 DR DSMZCellDive; ACC-47 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR ENCODE; ENCBS100ZVH DR ENCODE; ENCBS652PBR DR ENCODE; ENCBS662OGM DR ENCODE; ENCBS898JGF DR GDSC; 906842 DR GEO; GSM115817 DR GEO; GSM179646 DR GEO; GSM201345 DR GEO; GSM886987 DR GEO; GSM888056 DR GEO; GSM1035327 DR GEO; GSM1374467 DR GEO; GSM1527310 DR GEO; GSM1527311 DR GEO; GSM1527312 DR GEO; GSM1527313 DR GEO; GSM1527314 DR GEO; GSM1527315 DR GEO; GSM1669740 DR IARC_TP53; 21310 DR IARC_TP53; 25029 DR ICLC; HTL99022 DR IGRhCellID; DOHH2 DR IZSLER; BS TCL 228 DR LiGeA; CCLE_934 DR LINCS_LDP; LCL-1143 DR Lonza; 666 DR PharmacoDB; DOHH2_303_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1179 DR PubChem_Cell_line; CVCL_1179 DR Wikidata; Q54831350 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=1849602; RX PubMed=7849311; RX PubMed=8057678; RX PubMed=8558920; RX PubMed=16960149; RX PubMed=17363600; RX PubMed=17495976; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20454443; RX PubMed=22460905; RX PubMed=23699601; RX PubMed=25355872; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25960936; RX PubMed=26589293; RX PubMed=26727417; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30165192; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=31395879; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lymphoma-xenograft/dohh2-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: LL-100 blood cancer cell line panel. CC Part of: MD Anderson Cell Lines Project. CC Part of: TCGA-110-CL cell line panel. CC Population: Caucasian. CC Doubling time: 48 hours (Note=In RPMI 1640 + 5% FBS) (PubMed=1849602); ~40 hours (DSMZ=ACC-47). CC HLA typing: A*01:01,01:01; B*08:01,44:02; C*07:04,07:04; DQA1*01:02,01:02; DQB1*05:01,06:02; DRB1*15:01,01:01 (PubMed=25960936). CC HLA typing: A*01:01,01:01; B*08:01,44:02; C*07:01,07:01 (PubMed=26589293). CC HLA typing: A*01:01:01,01:01:01; B*08:01:01,44:02:01; C*07:01:01,07:04:01; DPA1*01:03:01,01:03:01; DPB1*03:01:01,02:01:02; DQA1*01:02:01,01:01:01; DQB1*05:01:01,06:02:01; DRA*01:01:01,01:02:03; DRB1*01:01:01,15:01:01 (DSMZCellDive=ACC-47). CC Microsatellite instability: Stable (MSS) (Sanger). CC Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). CC Omics: Genomics; ChIP-seq; H3K9ac. CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq virome analysis. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.28%; Native American=1.29%; East Asian, North=0%; East Asian, South=0%; South Asian=1.29%; European, North=69.22%; European, South=27.92% (PubMed=30894373). CC Miscellaneous: Originally assigned to be from a B-cell non-Hodgkin lymphoma, immunoblastic-type. CC Caution: A TP53 mutation is indicated as being at p.Ala138Pro (c.412G>C) in PubMed=17363600 but has not been confirmed by CCLE and Cosmic-CLP. CC Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): Cosmic-CLP=906842; DSMZ=ACC-47; IZSLER=BS TCL 228; PubMed=25877200 ST Amelogenin: X,Y ST CSF1PO: 11,12 ST D13S317: 12,13 ST D16S539: 11,14 ST D18S51: 11,14 ST D19S433: 14.2,15.2 ST D21S11: 30 ST D2S1338: 22,24 ST D3S1358: 15,17 ST D5S818: 11,12 ST D7S820: 11 ST D8S1179: 13,16 ST FGA: 21,27 ST Penta D: 9,12 ST Penta E: 12,16 ST TH01: 9 ST TPOX: 8,11 ST vWA: 14,19 DI NCIt; C36080; Diffuse large B-cell lymphoma germinal center B-cell type DI ORDO; Orphanet_544; Diffuse large B-cell lymphoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 60Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler H.G.; RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=1849602; RA Kluin-Nelemans H.C., Limpens J., Meerabux J., Beverstock G.C., RA Jansen J.H., de Jong D., Kluin P.M.; RT "A new non-Hodgkin's B-cell line (DoHH2) with a chromosomal RT translocation t(14;18)(q32;q21)."; RL Leukemia 5:221-224(1991). // RX PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893; RA Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., RA De Lord C.F.M., Clutterbuck R.D., Treleaven J.G., Powles R.L., RA Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., RA Millar J.L., Catovsky D., Dyer M.J.S.; RT "Deletions and rearrangement of CDKN2 in lymphoid malignancy."; RL Blood 85:893-901(1995). // RX PubMed=8057678; RA de Kroon J.F.E.M., Kluin P.M., Kluin-Nelemans H.C., Willemze R., RA Falkenburg J.H.F.; RT "Homing and antigenic characterization of a human non-Hodgkin's RT lymphoma B cell line in severe combined immunodeficient (SCID) mice."; RL Leukemia 8:1385-1391(1994). // RX PubMed=8558920; RA Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., RA Quentmeier H., Drexler H.G.; RT "The (2;5)(p23;q35) translocation in cell lines derived from malignant RT lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines."; RL Leukemia 10:142-149(1996). // RX PubMed=16960149; DOI=10.1182/blood-2006-06-026500; RA Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., RA Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., RA Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., RA Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., RA Martinez-Climent J.A.; RT "Homozygous deletions localize novel tumor suppressor genes in B-cell RT lymphomas."; RL Blood 109:271-280(2007). // RX PubMed=17363600; DOI=10.1158/0008-5472.CAN-06-3254; RA Strauss S.J., Higginbottom K., Juliger S., Maharaj L., Allen P., RA Schenkein D., Lister T.A., Joel S.P.; RT "The proteasome inhibitor bortezomib acts independently of p53 and RT induces cell death via apoptosis and mitotic catastrophe in B-cell RT lymphoma cell lines."; RL Cancer Res. 67:2783-2790(2007). // RX PubMed=17495976; DOI=10.1038/sj.leu.2404696; RA Fitzgibbon J., Iqbal S., Davies A.J., O'Shea D., Carlotti E., RA Chaplin T., Matthews J., Raghavan M., Norton A.J., Lister T.A., RA Young B.D.; RT "Genome-wide detection of recurring sites of uniparental disomy in RT follicular and transformed follicular lymphoma."; RL Leukemia 21:1514-1520(2007). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., RA Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., RA Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., RA Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.; RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., RA Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., RA Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., RA Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., RA Haber D.A.; RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168; RA Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.; RT "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human RT and other primate cell lines."; RL J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., RA Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., RA Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., RA Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., RA Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., RA Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., RA Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., RA Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., RA Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., RA Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., RA Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.; RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=23699601; DOI=10.1182/blood-2013-02-483727; PMCID=PMC3744992; RA Morin R.D., Mungall K., Pleasance E.D., Mungall A.J., Goya R., RA Huff R.D., Scott D.W., Ding J.-R., Roth A., Chiu R., Corbett R.D., RA Chan F.C., Mendez-Lago M., Trinh D.L., Bolger-Munro M., Taylor G., RA Hadj Khodabakhshi A., Ben-Neriah S., Pon J., Meissner B., Woolcock B.W., RA Farnoud N., Rogic S., Lim E.L., Johnson N.A., Shah S.P., Jones S.J.M., RA Steidl C., Holt R.A., Birol I., Moore R., Connors J.M., Gascoyne R.D., RA Marra M.A.; RT "Mutational and structural analysis of diffuse large B-cell lymphoma RT using whole-genome sequencing."; RL Blood 122:1256-1265(2013). // RX PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145; RA Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., RA O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.; RT "High-throughput RNA sequencing-based virome analysis of 50 lymphoma RT cell lines from the Cancer Cell Line Encyclopedia project."; RL J. 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Biotechnol. 33:306-312(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., RA Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., RA Neve R.M.; RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.; RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., RA Loewer M., Sahin U., Castle J.C.; RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=26727417; DOI=10.3109/10428194.2015.1108414; RA Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.; RT "Malignant hematopoietic cell lines: in vitro models for double-hit RT B-cell lymphomas."; RL Leuk. Lymphoma 57:1015-1020(2016). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., RA Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., RA Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., RA Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., RA Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., RA Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., RA Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., RA Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.; RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., RA Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., RA Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., RA Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., RA Liang H.; RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020; RA Qu C.-J., Kunkalla K., Vaghefi A., Frederiksen J.K., Liu Y.-D., RA Chapman J.R., Blonska M., Bernal-Mizrachi L., Alderuccio J.P., RA Lossos I.S., Landgraf R., Vega-Vazquez F.; RT "Smoothened stabilizes and protects TRAF6 from degradation: a novel RT non-canonical role of smoothened with implications in lymphoma RT biology."; RL Cancer Lett. 436:149-158(2018). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., RA Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., RA Yang H.H., Koeffler H.P.; RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.; RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.; RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., RA McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., RA Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., RA Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., RA Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., RA Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., RA Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., RA Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., RA Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., RA Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., RA Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., RA Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., RA Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., RA Sellers W.R.; RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646; RA Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., RA MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.; RT "The LL-100 panel: 100 cell lines for blood cancer studies."; RL Sci. 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