ID DMS 273 AC CVCL_1176 SY DMS-273; DMS273; Darmouth Medical School 273 DR BTO; BTO_0005903 DR CLO; CLO_0002797 DR EFO; EFO_0002164 DR CLDB; cl1079 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03472955 DR BioSample; SAMN10987982 DR cancercelllines; CVCL_1176 DR Cell_Model_Passport; SIDM00522 DR ChEMBL-Cells; CHEMBL3308487 DR ChEMBL-Targets; CHEMBL614034 DR Cosmic; 687985 DR Cosmic; 1436015 DR Cosmic; 1609521 DR Cosmic; 2125191 DR Cosmic; 2648003 DR Cosmic-CLP; 687985 DR DepMap; ACH-000749 DR ECACC; 95062830 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 687985 DR GEO; GSM827419 DR GEO; GSM886982 DR GEO; GSM888051 DR GEO; GSM1669736 DR GEO; GSM1887904 DR GEO; GSM1887987 DR IARC_TP53; 21307 DR IGRhCellID; DMS273 DR LiGeA; CCLE_304 DR LINCS_LDP; LCL-1807 DR PharmacoDB; DMS273_299_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1176 DR PubChem_Cell_line; CVCL_1176 DR Wikidata; Q54831301 RX PubMed=2041050; RX PubMed=2986244; RX PubMed=3335022; RX PubMed=9212023; RX PubMed=9744504; RX PubMed=12712436; RX PubMed=15900046; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22336246; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25960936; RX PubMed=26589293; RX PubMed=27247353; RX PubMed=27397505; RX PubMed=28766886; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=32586373; RX PubMed=35839778; WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/dms273-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR39 cancer cell line panel. CC Population: Caucasian. CC Doubling time: 6.2 days (PubMed=2986244). CC HLA typing: A*03:01,23:01; B*35:03,44:03; C*04:01,04:01; DRB1*07:01,07:01 (PubMed=25960936). CC HLA typing: A*03:01,23:01; B*35:03,44:03; C*04:01,04:01; DRB1*07:01,07:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:7910; NPM1; Simple; p.Asp173del (c.511_513delGAT); Zygosity=Heterozygous (Cosmic-CLP=687985; DepMap=ACH-000749). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Homozygous (PubMed=15900046; Cosmic-CLP=687985; DepMap=ACH-000749). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.51%; Native American=0.88%; East Asian, North=1.83%; East Asian, South=0%; South Asian=0%; European, North=66.84%; European, South=29.94% (PubMed=30894373). CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): Cosmic-CLP=687985; ECACC=95062830; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 12,13 ST D16S539: 11 ST D18S51: 12,16 ST D21S11: 28,31 ST D3S1358: 16 ST D5S818: 11,12 ST D7S820: 10,12 ST D8S1179: 12,13 ST FGA: 20 ST Penta D: 9,11 ST Penta E: 13 ST TH01: 9.3 ST TPOX: 10 ST vWA: 15 DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 50Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 // RX PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526; RA Krushkal, Julia RA Silvers, Thomas E. RA Reinhold, William C. RA Sonkin, Dmitriy RA Vural, Suleyman RA Connelly, John RA Varma, Sudhir RA Meltzer, Paul S. RA Kunkel, Mark W. RA Rapisarda, Annamaria RA Evans, David RA Pommier, Yves RA Teicher, Beverly A. RT "Epigenome-wide DNA methylation analysis of small cell lung cancer RT cell lines suggests potential chemotherapy targets."; RL Clin. Epigenetics 12:93.1-93.28(2020). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel, Sebastian RA Lower, Martin RA Bukur, Thomas RA Sahin, Ugur RA Castle, John C. RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=12712436; DOI=10.1002/ijc.11106; RA Hansen, Lasse Tengbjerg RA Lundin, Cecilia RA Spang-Thomsen, Mogens RA Petersen, Lone Norgard RA Helleday, Thomas RT "The role of RAD51 in etoposide (VP16) resistance in small cell lung RT cancer."; RL Int. J. Cancer 105:472-479(2003). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282; RA Polley, Eric C. RA Kunkel, Mark W. RA Evans, David RA Silvers, Thomas E. RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Selby, Michael RA Connelly, John RA Harris, Erik RA Fer, Nicole RA Sonkin, Dmitriy RA Kaur, Gurmeet RA Monks, Anne RA Malik, Shakun RA Morris, Joel RA Teicher, Beverly A. RT "Small cell lung cancer screen of oncology drugs, investigational RT agents, and gene and microRNA expression."; RL J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin K. RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=3335022; RA Alley, Michael C. RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=2041050; DOI=10.1093/jnci/83.11.757; RA Monks, Anne RA Scudiero, Dominic A. RA Skehan, Philip RA Shoemaker, Robert H. RA Paull, Kenneth D. RA Vistica, David T. RA Hose, Curtis D. RA Langley, John RA Cronise, Paul RA Vaigro-Wolff, Anne RA Gray-Goodrich, Marcia RA Campbell, Hugh RA Mayo, Joseph G. RA Boyd, Michael R. RT "Feasibility of a high-flux anticancer drug screen using a diverse RT panel of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 83:757-766(1991). // RX PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9; RA Krarup, Marianne RA Poulsen, Hans Skovgaard RA Spang-Thomsen, Mogens RT "Cellular radiosensitivity of small-cell lung cancer cell lines."; RL Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima, Tetsuo RA Oh-hara, Tomoko RA Sato, Shigeo RA Mochizuki, Mikiko RA Sugimoto, Yoshikazu RA Yamazaki, Kanami RA Hamada, Jun-ichi RA Tada, Mitsuhiro RA Moriuchi, Tetsuya RA Ishikawa, Yuichi RA Kato, Yo RA Tomoda, Hiroshi RA Yamori, Takao RA Tsuruo, Takashi RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065; RA Damstrup, Lars RA Voldborg, Bjorn Gunnar Rude RA Spang-Thomsen, Mogens RA Brunner, Nils RA Poulsen, Hans Skovgaard RT "In vitro invasion of small-cell lung cancer cell lines correlates RT with expression of epidermal growth factor receptor."; RL Br. J. Cancer 78:631-640(1998). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong, De-Xin RA Yamori, Takao RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5; RA Vindelov, Lars L. RA Hansen, Heine Hoi RA Spang-Thomsen, Mogens RT "Growth characteristics and heterogeneity of small cell carcinoma of RT the lung."; RL Recent Results Cancer Res. 97:47-54(1985). // RX PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882; RA Teicher, Beverly A. RA Silvers, Thomas E. RA Selby, Michael RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Parchment, Ralph E. RA Krushkal, Julia RA Sonkin, Dmitriy RA Rubinstein, Lawrence RA Morris, Joel RA Evans, David RT "Small cell lung carcinoma cell line screen of etoposide/carboplatin RT plus a third agent."; RL Cancer Med. 6:1952-1964(2017). //