ID DMS 114 AC CVCL_1174 SY DMS-114; DMS114; Darmouth Medical School 114 DR BTO; BTO_0004813 DR CLO; CLO_0002795 DR EFO; EFO_0002162 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2066 DR BioGRID_ORCS_Cell_line; 805 DR BioSample; SAMN03471429 DR BioSample; SAMN10988190 DR cancercelllines; CVCL_1174 DR Cell_Model_Passport; SIDM00865 DR ChEMBL-Cells; CHEMBL3307670 DR ChEMBL-Targets; CHEMBL614642 DR Cosmic; 687983 DR Cosmic; 1436016 DR Cosmic; 2125177 DR Cosmic; 2648005 DR Cosmic-CLP; 687983 DR DepMap; ACH-000530 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10841-111E4 DR GDSC; 687983 DR GEO; GSM784211 DR GEO; GSM886980 DR GEO; GSM888049 DR GEO; GSM1374464 DR GEO; GSM1374465 DR GEO; GSM1374466 DR GEO; GSM1669735 DR GEO; GSM1887902 DR GEO; GSM1887985 DR IARC_TP53; 21305 DR IARC_TP53; 21640 DR IGRhCellID; DMS114 DR LiGeA; CCLE_413 DR LINCS_LDP; LCL-1830 DR NCI-DTP; DMS-114 DR PharmacoDB; DMS114_297_2019 DR PRIDE; PXD011896 DR PRIDE; PXD030304 DR Progenetix; CVCL_1174 DR PubChem_Cell_line; CVCL_1174 DR Wikidata; Q54831291 RX PubMed=2041050; RX PubMed=2388294; RX PubMed=2986244; RX PubMed=3335022; RX PubMed=6266631; RX PubMed=7718330; RX PubMed=9212023; RX PubMed=9744504; RX PubMed=12712436; RX PubMed=15900046; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22336246; RX PubMed=22460905; RX PubMed=22961666; RX PubMed=27247353; RX PubMed=27397505; RX PubMed=28766886; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=32586373; RX PubMed=35839778; RX PubMed=38180245; WW Info; NCI DTP; NCI-60 additional lines; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: FGFR genetic alteration cell panel (ATCC TCP-1034). CC Part of: JFCR39 cancer cell line panel. CC Part of: KuDOS 95 cell line panel. CC Population: Caucasian. CC Doubling time: 3.8 days (PubMed=6266631); 1.6 days (PubMed=2986244); 27 hours (PubMed=7718330). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:14446; PARD3B; Unexplicit; Ex2-14del; Zygosity=Homozygous (PubMed=20215515). CC Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Glu1310Ter (c.3928G>T); Zygosity=Homozygous (DepMap=ACH-000530). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Homozygous (PubMed=15900046; Cosmic-CLP=687983; DepMap=ACH-000530). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.44%; Native American=0.11%; East Asian, North=2.38%; East Asian, South=0%; South Asian=0%; European, North=55.93%; European, South=41.14% (PubMed=30894373). CC Caution: Originally classified as originating from a lung small cell carcinoma, but is reclassified as a thoracic SMARCA4-deficient undifferentiated tumor based on a number of criteria (PubMed=38180245). CC Misspelling: DMS 144; FANTOM5_SSTAR=10841-111E4. CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): ATCC=CRL-2066; Cosmic-CLP=687983 ST Amelogenin: X ST CSF1PO: 10,11 ST D13S317: 13 ST D16S539: 12 ST D18S51: 18 ST D19S433: 13 ST D21S11: 29 ST D2S1338: 17 ST D3S1358: 14,17 ST D5S818: 12 ST D7S820: 10,11 ST D8S1179: 12,13 ST FGA: 21 ST Penta D: 11,13 ST Penta E: 7,13 ST TH01: 8,9.3 ST TPOX: 8,11 ST vWA: 16,17 DI NCIt; C183115; Thoracic SMARCA4-deficient undifferentiated tumor OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 68Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 // RX PubMed=2041050; DOI=10.1093/jnci/83.11.757; RA Monks, Anne RA Scudiero, Dominic A. RA Skehan, Philip RA Shoemaker, Robert H. RA Paull, Kenneth D. RA Vistica, David T. RA Hose, Curtis D. RA Langley, John RA Cronise, Paul RA Vaigro-Wolff, Anne RA Gray-Goodrich, Marcia RA Campbell, Hugh RA Mayo, Joseph G. RA Boyd, Michael R. RT "Feasibility of a high-flux anticancer drug screen using a diverse RT panel of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 83:757-766(1991). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=7718330; DOI=10.1016/0959-8049(94)00472-H; RA Baguley, Bruce Charles RA Marshall, Elaine S. RA Whittaker, John Richard RA Dotchin, M.C. RA Nixon, Johanna RA McCrystal, Michael R. RA Finlay, Graeme John RA Matthews, John H.L. RA Holdaway, Karen M. RA van Zijl, Pierre Leonardus RT "Resistance mechanisms determining the in vitro sensitivity to RT paclitaxel of tumour cells cultured from patients with ovarian RT cancer."; RL Eur. J. Cancer 31A:230-237(1995). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong, De-Xin RA Yamori, Takao RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=32586373; DOI=10.1186/s13148-020-00876-8; PMCID=PMC7318526; RA Krushkal, Julia RA Silvers, Thomas E. RA Reinhold, William C. RA Sonkin, Dmitriy RA Vural, Suleyman RA Connelly, John RA Varma, Sudhir RA Meltzer, Paul S. RA Kunkel, Mark W. RA Rapisarda, Annamaria RA Evans, David RA Pommier, Yves RA Teicher, Beverly A. RT "Epigenome-wide DNA methylation analysis of small cell lung cancer RT cell lines suggests potential chemotherapy targets."; RL Clin. Epigenetics 12:93.1-93.28(2020). // RX PubMed=2388294; DOI=10.1093/jnci/82.17.1420; RA McLemore, Theodore L. RA Litterst, Charles L. RA Coudert, Bruno P. RA Liu, Mark C. RA Hubbard, Walter C. RA Adelberg, Steven RA Czerwinski, Maciej J. RA McMahon, Noreen A. RA Eggleston, Joseph C. RA Boyd, Michael R. RT "Metabolic activation of 4-ipomeanol in human lung, primary pulmonary RT carcinomas, and established human pulmonary carcinoma cell lines."; RL J. Natl. Cancer Inst. 82:1420-1426(1990). // RX PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065; RA Damstrup, Lars RA Voldborg, Bjorn Gunnar Rude RA Spang-Thomsen, Mogens RA Brunner, Nils RA Poulsen, Hans Skovgaard RT "In vitro invasion of small-cell lung cancer cell lines correlates RT with expression of epidermal growth factor receptor."; RL Br. J. Cancer 78:631-640(1998). // RX PubMed=3335022; RA Alley, Michael Curtis RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::AID-CNCR2820450513>3.0.CO;2-H; RA Pettengill, Olive S. RA Sorenson, George D. RA Wurster-Hill, Doris H. RA Curphey, Thomas J. RA Noll, Walter W. RA Cate, Charles C. RA Maurer, Lloyd Herbert RT "Isolation and growth characteristics of continuous cell lines from RT small-cell carcinoma of the lung."; RL Cancer 45:906-918(1980). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima, Tetsuo RA Oh-hara, Tomoko RA Sato, Shigeo RA Mochizuki, Mikiko RA Sugimoto, Yoshikazu RA Yamazaki, Kanami RA Hamada, Jun-ichi RA Tada, Mitsuhiro RA Moriuchi, Tetsuya RA Ishikawa, Yuichi RA Kato, Yo RA Tomoda, Hiroshi RA Yamori, Takao RA Tsuruo, Takashi RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5; RA Vindelov, Lars L. RA Hansen, Heine Hoi RA Spang-Thomsen, Mogens RT "Growth characteristics and heterogeneity of small cell carcinoma of RT the lung."; RL Recent Results Cancer Res. 97:47-54(1985). // RX PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882; RA Teicher, Beverly A. RA Silvers, Thomas E. RA Selby, Michael RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Parchment, Ralph E. RA Krushkal, Julia RA Sonkin, Dmitriy RA Rubinstein, Lawrence RA Morris, Joel RA Evans, David RT "Small cell lung carcinoma cell line screen of etoposide/carboplatin RT plus a third agent."; RL Cancer Med. 6:1952-1964(2017). // RX PubMed=12712436; DOI=10.1002/ijc.11106; RA Hansen, Lasse Tengbjerg RA Lundin, Cecilia RA Spang-Thomsen, Mogens RA Petersen, Lone Norgard RA Helleday, Thomas RT "The role of RAD51 in etoposide (VP16) resistance in small cell lung RT cancer."; RL Int. J. Cancer 105:472-479(2003). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers, Lauren Averett RA Wang, Jing RA Nilsson, Monique B. RA Fujimoto, Junya RA Saintigny, Pierre RA Yordy, John Stuart RA Giri, Uma RA Peyton, Michael RA Fan, You-Hong RA Diao, Li-Xia RA Masrorpour, Fatemeh RA Shen, Li RA Liu, Wen-Bin RA Duchemann, Boris RA Tumula, Praveen RA Bhardwaj, Vikas RA Welsh, James RA Weber, Stephanie RA Glisson, Bonnie S. RA Kalhor, Neda RA Wistuba, Ignacio Ivan RA Girard, Luc RA Lippman, Scott M. RA Mills, Gordon B. RA Coombes, Kevin Robert RA Weinstein, John N. RA Minna, John D. RA Heymach, John Victor RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9; RA Krarup, Marianne RA Poulsen, Hans Skovgaard RA Spang-Thomsen, Mogens RT "Cellular radiosensitivity of small-cell lung cancer cell lines."; RL Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997). // RX PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282; RA Polley, Eric C. RA Kunkel, Mark W. RA Evans, David RA Silvers, Thomas E. RA Delosh, Rene M. RA Laudeman, Julie RA Ogle, Chad RA Reinhart, Russell RA Selby, Michael RA Connelly, John RA Harris, Erik RA Fer, Nicole RA Sonkin, Dmitriy RA Kaur, Gurmeet RA Monks, Anne RA Malik, Shakun RA Morris, Joel RA Teicher, Beverly A. RT "Small cell lung cancer screen of oncology drugs, investigational RT agents, and gene and microRNA expression."; RL J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=38180245; DOI=10.1158/1078-0432.CCR-23-2360; PMCID=PMC11061608; RA Ng, Jin RA Cai, Ling RA Girard, Luc RA Prall, Owen W.J. RA Rajan, Neeha Sulakshi RA Khoo, Christine RA Batrouney, Ahida RA Byrne, David J. RA Boyd, Danielle K. RA Kersbergen, Ariena J. RA Christie, Michael RA Minna, John D. RA Burr, Marian L. RA Sutherland, Kate D. RT "Molecular and pathologic characterization of YAP1-expressing small RT cell lung cancer cell lines leads to reclassification as RT SMARCA4-deficient malignancies."; RL Clin. Cancer Res. 30:1846-1858(2024). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //