ID CHP-212 AC CVCL_1125 AS CVCL_A797 SY CHP 212; CHP212; NB9; NB-9; Children's Hospital of Philadelphia-212 DR CLO; CLO_0002467 DR CLO; CLO_0002473 DR CLO; CLO_0050261 DR EFO; EFO_0002133 DR CLDB; cl771 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2273 DR BioGRID_ORCS_Cell_line; 595 DR BioSample; SAMN03472322 DR BioSample; SAMN03473208 DR BioSample; SAMN10988326 DR cancercelllines; CVCL_1125 DR Cell_Model_Passport; SIDM00910 DR ChEMBL-Cells; CHEMBL3308101 DR ChEMBL-Targets; CHEMBL1075423 DR Cosmic; 724826 DR Cosmic; 906820 DR Cosmic; 920244 DR Cosmic; 1161987 DR Cosmic; 2131574 DR Cosmic-CLP; 906820 DR DepMap; ACH-000120 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 906820 DR GEO; GSM563361 DR GEO; GSM886930 DR GEO; GSM887996 DR GEO; GSM1366405 DR GEO; GSM1669678 DR GEO; GSM2371223 DR GEO; GSM2394381 DR IARC_TP53; 21227 DR IGRhCellID; CHP212 DR LiGeA; CCLE_207 DR LINCS_LDP; LCL-1964 DR PharmacoDB; CHP212_200_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1125 DR PubChem_Cell_line; CVCL_1125 DR RCB; RCB0477 DR Wikidata; Q54813267 RX DOI=10.1007/0-306-46872-7_2; RX DOI=10.1016/B978-0-12-008304-6.50015-4; RX DOI=10.1016/B978-0-12-333530-2.50006-X; RX PubMed=6113887; RX PubMed=7139592; RX PubMed=12068308; RX PubMed=15720811; RX PubMed=15892104; RX PubMed=18724359; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28350380; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; RX PubMed=39255063; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: RAS genetic alteration cell panel (ATCC TCP-1031). CC Population: Caucasian. CC Characteristics: Intermediate type (I-type) (PubMed=15720811). CC HLA typing: A*02:01,24:02; B*07:07,58:05; C*07:02,07:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=12068308; ATCC=CRL-2273; Cosmic-CLP=906820; DepMap=ACH-000120). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Extrachromosomal circular DNA (scEC); Single cell. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Transcriptomics; RNAseq; Single cell. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.16%; Native American=0%; East Asian, North=1.09%; East Asian, South=0.43%; South Asian=0.86%; European, North=70.26%; European, South=25.19% (PubMed=30894373). CC Derived from site: In situ; Brain; UBERON=UBERON_0000955. ST Source(s): ATCC=CRL-2273; Cosmic-CLP=906820; PubMed=25877200; RCB=RCB0477 ST Amelogenin: X,Y ST CSF1PO: 12 ST D13S317: 8 (RCB=RCB0477) ST D13S317: 8,13 (ATCC=CRL-2273; Cosmic-CLP=906820; PubMed=25877200) ST D16S539: 13 ST D18S51: 14,16 ST D19S433: 12,15 ST D21S11: 27,29 ST D2S1338: 22,25 ST D3S1358: 15,17 ST D5S818: 10,12 ST D7S820: 11 ST D8S1179: 11,13 ST FGA: 20 ST Penta D: 9,10 ST Penta E: 5,15 ST TH01: 6 (ATCC=CRL-2273; Cosmic-CLP=906820; PubMed=25877200) ST TH01: 6,7 (RCB=RCB0477) ST TPOX: 8,11 ST vWA: 15,18 DI NCIt; C3270; Neuroblastoma DI ORDO; Orphanet_635; Neuroblastoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 1Y8M CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 44 // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=6113887; RA Schlesinger, Harvey R. RA Rorke-Adams, Lucy Balian RA Jamieson, R. RA Hummeler, Klaus RT "Neuronal properties of neuroectodermal tumors in vitro."; RL Cancer Res. 41:2573-2575(1981). // RX PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043; RA Mosse, Yael P. RA Laudenslager, Marci RA Longo, Luca RA Cole, Kristina A. RA Wood, Andrew RA Attiyeh, Edward Fathi RA Laquaglia, Michael J. RA Sennett, Rachel RA Lynch, Jill E. RA Perri, Patrizia RA Laureys, Genevieve RA Speleman, Frank RA Kim, Cecilia RA Hou, Cui-Ping RA Hakonarson, Hakon RA Torkamani, Ali RA Schork, Nicholas J. RA Brodeur, Garrett M. RA Tonini, Gian Paolo RA Rappaport, Eric RA Devoto, Marcella RA Maris, John Matthew RT "Identification of ALK as a major familial neuroblastoma RT predisposition gene."; RL Nature 455:930-935(2008). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX DOI=10.1016/B978-0-12-333530-2.50006-X; RA Israel, Mark A. RA Thiele, Carol Jeanne RT "Tumor cell lines of the peripheral nervous system."; RL (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994). // RX PubMed=39255063; DOI=10.1016/j.celrep.2024.114711; RA Stober, Maja-Celine RA Chamorro Gonzalez, Rocio RA Bruckner, Lotte RA Conrad, Thomas RA Wittstruck, Nadine RA Krienelke Szymansky, Annabell RA Eggert, Angelika RA Schulte, Johannes Hubertus RA Koche, Richard Patrick RA Henssen, Anton George RA Schwarz, Roland F. RA Haase, Kerstin RT "Intercellular extrachromosomal DNA copy-number heterogeneity drives RT neuroblastoma cell state diversity."; RL Cell Rep. 43:114711.1-114711.19(2024). // RX DOI=10.1016/B978-0-12-008304-6.50015-4; RA Biedler, June Lee RA Meyers, Marian B. RA Spengler, Barbara A. RT "Homogeneously staining regions and double minute chromosomes, RT prevalent cytogenetic abnormalities of human neuroblastoma cells."; RL (In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983). // RX PubMed=15892104; DOI=10.1002/gcc.20198; RA Mosse, Yael P. RA Greshock, Joel RA Margolin, Adam A. RA Naylor, Tara RA Cole, Kristina A. RA Khazi, Deepa RA Hii, George RA Winter, Cynthia RA Shahzad, Syed RA Asziz, Muhammad Usman RA Biegel, Jaclyn A. RA Weber, Barbara L. RA Maris, John Matthew RT "High-resolution detection and mapping of genomic DNA alterations in RT neuroblastoma."; RL Genes Chromosomes Cancer 43:390-403(2005). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX DOI=10.1007/0-306-46872-7_2; RA Thiele, Carol Jeanne RT "Neuroblastoma."; RL (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999). // RX PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315; RA Harenza, Jo Lynne RA Diamond, Maura A. RA Adams, Rebecca N. RA Song, Michael M. RA Davidson, Heather L. RA Hart, Lori S. RA Dent, Maiah H. RA Fortina, Paolo RA Reynolds, Charles Patrick RA Maris, John Matthew RT "Transcriptomic profiling of 39 commonly-used neuroblastoma cell RT lines."; RL Sci. Data 4:170033.1-170033.8(2017). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=15720811; DOI=10.1593/neo.04310; PMCID=PMC1531688; RA Walton, Jeanette D. RA Kattan, David R. RA Thomas, Sharon K. RA Spengler, Barbara A. RA Guo, Hong-Fen RA Biedler, June Lee RA Cheung, Nai-Kong V. RA Ross, Robert A. RT "Characteristics of stem cells from human neuroblastoma cell lines and RT in tumors."; RL Neoplasia 6:838-845(2004). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathy RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne M. RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4; RA Gilbert, Fred RA Balaban-Malenbaum, Gloria Brady RA Moorhead, Paul Sidney RA Bianchi, Diana W. RA Schlesinger, Harvey R. RT "Abnormalities of chromosome 1p in human neuroblastoma tumors and cell RT lines."; RL Cancer Genet. Cytogenet. 7:33-42(1982). //