ID CGTH-W-1 AC CVCL_1120 SY CGTH-W1; CGTH W-1; CGTHW1 DR BTO; BTO_0004740 DR CLO; CLO_0002406 DR EFO; EFO_0002131 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03470999 DR BioSample; SAMN03473318 DR BioSample; SAMN10987694 DR cancercelllines; CVCL_1120 DR Cell_Model_Passport; SIDM01248 DR ChEMBL-Cells; CHEMBL3308849 DR ChEMBL-Targets; CHEMBL2366300 DR Cosmic; 910568 DR Cosmic; 1995365 DR Cosmic; 2054098 DR Cosmic-CLP; 910568 DR DepMap; ACH-001023 DR DSMZ; ACC-360 DR DSMZCellDive; ACC-360 DR EGA; EGAS00001000978 DR GDSC; 910568 DR GEO; GSM886926 DR GEO; GSM887992 DR GEO; GSM1669673 DR IARC_TP53; 21223 DR IGRhCellID; CGTHW1 DR LINCS_LDP; LCL-1691 DR PharmacoDB; CGTHW1_194_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1120 DR PubChem_Cell_line; CVCL_1120 DR Wikidata; Q54811588 RX PubMed=8826082; RX PubMed=8888804; RX PubMed=11668190; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=23833040; RX PubMed=25877200; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Contaminated. Shown to be a SW579 derivative (PubMed=25877200; DSMZ). Originally thought to originate from a thyroid gland follicular carcinoma metastasizing to the sternum of a 70 year old Chinese female patient. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00536. CC Population: Caucasian. CC Doubling time: ~18 hours (PubMed=8888804); ~20-25 hours (DSMZ=ACC-360). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile255Ser (c.764T>G); ClinVar=VCV000376622; Zygosity=Homozygous (Cosmic-CLP=910568; DepMap=ACH-001023). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=2.04%; East Asian, North=0.24%; East Asian, South=0%; South Asian=1.16%; European, North=64.53%; European, South=32.03% (PubMed=30894373). CC Discontinued: DSMZ; ACC-360; true. CC Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046. ST Source(s): Cosmic-CLP=910568; DSMZ=ACC-360; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 13 ST D13S317: 13 ST D16S539: 11 ST D18S51: 15,17 ST D19S433: 13,14 ST D21S11: 29,31 ST D2S1338: 17,18 ST D3S1358: 15,18 ST D5S818: 9,11 (DSMZ=ACC-360) ST D5S818: 11 (Cosmic-CLP=910568; PubMed=25877200) ST D7S820: 8,9 ST D8S1179: 11,13 ST FGA: 21,24 (PubMed=25877200) ST FGA: 21,24,25 (DSMZ=ACC-360) ST Penta D: 9 (PubMed=25877200) ST Penta D: 9,11,12 (DSMZ=ACC-360) ST Penta E: 11 (PubMed=25877200) ST Penta E: 11,12 (DSMZ=ACC-360) ST TH01: 8,9.3 ST TPOX: 8,10 ST vWA: 14,18 DI NCIt; C46008; Thyroid gland squamous cell carcinoma DI ORDO; Orphanet_100088; Thyroid carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_3603 ! SW579 SX Male AG 59Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=8888804; DOI=10.1002/(SICI)1096-9098(199610)63:2<112::AID-JSO8>3.0.CO;2-H; RA Lin, Jen-Der RA Chao, Tzu-Chieh RA Weng, Hsiao-Fen RA Huang, Hong-So RA Ho, Yat-Sen RT "Establishment of xenografts and cell lines from well-differentiated RT human thyroid carcinoma."; RL J. Surg. Oncol. 63:112-118(1996). // RX PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971; RA Landa, Inigo RA Ganly, Ian RA Chan, Timothy A. RA Mitsutake, Norisato RA Matsuse, Michiko RA Ibrahimpasic, Tihana RA Ghossein, Ronald A. RA Fagin, James Alexander RT "Frequent somatic TERT promoter mutations in thyroid cancer: higher RT prevalence in advanced forms of the disease."; RL J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8826082; DOI=10.1007/BF02634562; RA Lin, Jen-Der RA Ho, Yat-Sen RA Chang, Hsien-Yuan RA Weng, Hsiao-Fen RT "The role of insulin-like growth factor-1 (IGF-1) in follicular RT thyroid cancer cell line CGTH W-1."; RL In Vitro Cell. Dev. Biol. Anim. 31:817-821(1995). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). //