ID Ca9-22 AC CVCL_1102 SY CA9-22; Ca 9-22; CA922; Ca922 DR BTO; BTO_0005204 DR CLO; CLO_0051380 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 840 DR BioSample; SAMN01821673 DR cancercelllines; CVCL_1102 DR Cell_Model_Passport; SIDM00489 DR CGH-DB; 355-2 DR ChEMBL-Cells; CHEMBL3308714 DR ChEMBL-Targets; CHEMBL1075404 DR Cosmic; 753538 DR Cosmic; 930339 DR Cosmic; 932155 DR Cosmic; 1042302 DR Cosmic; 1046026 DR Cosmic; 1118791 DR Cosmic; 1120700 DR Cosmic; 1123036 DR Cosmic; 1140783 DR Cosmic; 1219867 DR Cosmic; 1317411 DR Cosmic; 2266786 DR Cosmic; 2546832 DR Cosmic-CLP; 753538 DR DepMap; ACH-002043 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10434-106E2 DR GDSC; 753538 DR GEO; GSM301576 DR GEO; GSM827235 DR GEO; GSM850380 DR GEO; GSM1669642 DR IARC_TP53; 1095 DR JCRB; JCRB0625 DR LINCS_HMS; 50007 DR LINCS_LDP; LCL-2033 DR PharmacoDB; Ca922_160_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1102 DR PubChem_Cell_line; CVCL_1102 DR RCB; RCB1976 DR TKG; TKG 0485 DR Wikidata; Q54808305 RX DOI=10.5794/jjoms.23.619; RX PubMed=275414; RX PubMed=1570156; RX PubMed=2228902; RX PubMed=4549822; RX PubMed=9023415; RX PubMed=9178645; RX PubMed=9247707; RX PubMed=9290701; RX PubMed=10069537; RX PubMed=10741724; RX PubMed=12738951; RX PubMed=15800904; RX PubMed=17052259; RX PubMed=17325662; RX PubMed=17599052; RX PubMed=18097548; RX PubMed=18973137; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=21868764; RX PubMed=27397505; RX PubMed=29156801; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=35839778; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Partially contaminated. Some stocks of Ca9-22 are contaminated with MSK-922 (PubMed=21868764). CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00437. CC Population: Japanese. CC HLA typing: A*02:07,24:02; B*35,46:01; C*01:02,14:02 (PubMed=9023415). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=1570156; PubMed=10741724; Cosmic-CLP=753538; DepMap=ACH-002043). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.96%; Native American=0%; East Asian, North=79.73%; East Asian, South=18.82%; South Asian=0%; European, North=0%; European, South=0.49% (PubMed=30894373). CC Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828. ST Source(s): Cosmic-CLP=753538; JCRB=JCRB0625; RCB=RCB1976; TKG=TKG 0485 ST Amelogenin: X,Y ST CSF1PO: 12 ST D13S317: 11 ST D16S539: 9,10 ST D5S818: 12 ST D7S820: 11,13 ST TH01: 6 ST TPOX: 8,11 ST vWA: 16 DI NCIt; C129857; Gingival squamous cell carcinoma DI ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 43Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 CH CVCL_HM42 ! Ca9-22PF CH CVCL_HM41 ! Ca9-22SF CH CVCL_2789 ! KOSC-3 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662; RA Zhao, Mei RA Sano, Daisuke RA Pickering, Curtis R. RA Jasser, Samar A. RA Henderson, Ying C. RA Clayman, Gary L. RA Sturgis, Erich M. RA Ow, Thomas J. RA Lotan, Reuben RA Carey, Thomas E. RA Sacks, Peter G. RA Grandis, Jennifer Rubin RA Sidransky, David RA Heldin, Nils-Erik RA Myers, Jeffrey N. RT "Assembly and initial characterization of a panel of 85 genomically RT validated cell lines from diverse head and neck tumor sites."; RL Clin. Cancer Res. 17:7248-7264(2011). // RX PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x; PMCID=PMC11160012; RA Kozaki, Ken-ichi RA Imoto, Issei RA Pimkhaokham, Atiphan RA Hasegawa, Shogo RA Tsuda, Hitoshi RA Omura, Ken RA Inazawa, Johji RT "PIK3CA mutation is an oncogenic aberration at advanced stages of oral RT squamous cell carcinoma."; RL Cancer Sci. 97:1351-1358(2006). // RX PubMed=17599052; DOI=10.1038/sj.onc.1210589; RA Suzuki, Emina RA Imoto, Issei RA Pimkhaokham, Atiphan RA Nakagawa, Takayuki RA Kamata, Nobuyuki RA Kozaki, Ken-ichi RA Amagasa, Teruo RA Inazawa, Johji RT "PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in RT oral squamous-cell carcinomas by aberrant promoter hypermethylation."; RL Oncogene 26:7921-7932(2007). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX DOI=10.5794/jjoms.23.619; RA Horikoshi, Masaru RA Katsumura, Asaki RA Fujibayashi, Takashi RA Soda, Tadao RA Itoh, Hideo RT "Lymphocyte mediated cytotoxicity to oral squamous cell carcinoma cell RT line (Ca 9-22)."; RL Nihon Koku Geka Gakkai Zasshi 23:619-625(1977). // RX PubMed=15800904; DOI=10.1002/ijc.21008; RA Tada, Takeyuki RA Jimi, Eijiro RA Okamoto, Masato RA Ozeki, Satoru RA Okabe, Koji RT "Oral squamous cell carcinoma cells induce osteoclast differentiation RT by suppression of osteoprotegerin expression in osteoblasts."; RL Int. J. Cancer 116:253-262(2005). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX PubMed=4549822; DOI=10.5794/jjoms.20.100; RA Horikoshi, Masaru RA Kimura, Yoshitaka RA Nagura, Hideaki RA Ono, Toaki RA Ito, Hideo RT "A new human cell line derived from human carcinoma of the gingiva. I. RT Its establishment and morphological studies."; RL Nihon Koku Geka Gakkai Zasshi 20:100-106(1974). // RX PubMed=10069537; DOI=10.1111/j.1600-0714.1999.tb02006.x; RA Hoteiya, Toshiaki RA Hayashi, Eiji RA Satomura, Kazuhito RA Kamata, Nobuyuki RA Nagayama, Masaru RT "Expression of E-cadherin in oral cancer cell lines and its RT relationship to invasiveness in SCID mice in vivo."; RL J. Oral Pathol. Med. 28:107-111(1999). // RX PubMed=17325662; DOI=10.1038/sj.onc.1210330; RA Nakaya, K. RA Yamagata, Hidehisa D. RA Arita, Norimasa RA Nakashiro, Koh-ichi RA Nose, Masato RA Miki, Tetsuro RA Hamakawa, Hiroyuki RT "Identification of homozygous deletions of tumor suppressor gene FAT RT in oral cancer using CGH-array."; RL Oncogene 26:5300-5308(2007). // RX PubMed=18973137; DOI=10.1002/gcc.20626; RA Sugimoto, Takashi RA Seki, Naohiko RA Shimizu, Satoya RA Kikkawa, Naoko RA Tsukada, Jun RA Shimada, Hideaki RA Sasaki, Keita RA Hanazawa, Toyoyuki RA Okamoto, Yoshitaka RA Hata, Akira RT "The galanin signaling cascade is a candidate pathway regulating RT oncogenesis in human squamous cell carcinoma."; RL Genes Chromosomes Cancer 48:132-142(2009). // RX PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691; RA Kalu, Nene N. RA Mazumdar, Tuhina RA Peng, Shao-Hua RA Shen, Li RA Sambandam, Vaishnav RA Rao, Xia-Yu RA Xi, Yuan-Xin RA Li, Le-Rong RA Qi, Yuan RA Gleber-Netto, Frederico O. RA Patel, Ameeta RA Wang, Jing RA Frederick, Mitchell J. RA Myers, Jeffrey N. RA Pickering, Curtis R. RA Johnson, Faye M. RT "Genomic characterization of human papillomavirus-positive and RT -negative human squamous cell cancer cell lines."; RL Oncotarget 8:86369-86383(2017). // RX PubMed=1570156; RA Sakai, Eiki RA Tsuchida, Nobuo RT "Most human squamous cell carcinomas in the oral cavity contain RT mutated p53 tumor-suppressor genes."; RL Oncogene 7:927-933(1992). // RX PubMed=275414; DOI=10.5357/koubyou.45.20; RA Kimura, Yoshitaka RT "Studies on lactate dehydrogenase isoenzymes in a cell line (Ca 9-22) RT derived from carcinoma of the gingiva."; RL Kokubyo Gakkai Zasshi 45:20-35(1978). // RX PubMed=9178645; DOI=10.1006/cimm.1997.1108; RA Nakao, Masanobu RA Sata, Michio RA Saitsu, Hideki RA Yutani, Shigeru RA Kawamoto, Mayumi RA Kojiro, Masamichi RA Itoh, Kyogo RT "CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with RT hepatocellular carcinoma."; RL Cell. Immunol. 177:176-181(1997). // RX PubMed=18097548; DOI=10.3892/ijo.32.1.101; RA Murugan, Avaniyapuram Kannan RA Hong, Nguyen Thi RA Fukui, Yasuhisa RA Munirajan, Arasambattu Kannan RA Tsuchida, Nobuo RT "Oncogenic mutations of the PIK3CA gene in head and neck squamous cell RT carcinomas."; RL Int. J. Oncol. 32:101-111(2008). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=12738951; DOI=10.1067/moe.2003.36; RA Sugiyama, Masaru RA Bhawal, Ujjal K. RA Dohmen, Tamiko RA Ono, Shigehiro RA Miyauchi, Miwa RA Ishikawa, Takenori RT "Detection of human papillomavirus-16 and HPV-18 DNA in normal, RT dysplastic, and malignant oral epithelium."; RL Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003). // RX PubMed=2228902; DOI=10.1007/BF02624609; RA Rikimaru, Koichi RA Toda, Hitomi RA Tachikawa, Noriko RA Kamata, Nobuyuki RA Enomoto, Shoji RT "Growth of the malignant and nonmalignant human squamous cells in a RT protein-free defined medium."; RL In Vitro Cell. Dev. Biol. 26:849-856(1990). // RX PubMed=9247707; DOI=10.1080/15216549700202901; RA Hatakeyama, Setsuko RA Gao, Yu-Hao RA Ohara-Nemoto, Yuko RA Kataoka, Hiroaki RA Satoh, Masanobu RT "Expression of bone morphogenetic proteins of human neoplastic RT epithelial cells."; RL Biochem. Mol. Biol. Int. 42:497-505(1997). // RX PubMed=9023415; DOI=10.1006/cimm.1996.1062; RA Seki, Naoko RA Hoshino, Tomoaki RA Kikuchi, Megumi RA Hayashi, Akihiro RA Itoh, Kyogo RT "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating RT lymphocytes of patients with non-small cell lung cancer."; RL Cell. Immunol. 175:101-110(1997). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=10741724; RA Eura, Masao RA Chikamatsu, Kazuaki RA Katsura, Fumihiro RA Obata, Atsushi RA Sobao, Yuji RA Takiguchi, Masafumi RA Song, Yong-Sheng RA Appella, Ettore RA Whiteside, Theresa L. RA DeLeo, Albert B. RT "A wild-type sequence p53 peptide presented by HLA-A24 induces RT cytotoxic T lymphocytes that recognize squamous cell carcinomas of the RT head and neck."; RL Clin. Cancer Res. 6:979-986(2000). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //