ID   Ca Ski
AC   CVCL_1100
SY   Ca-Ski; CaSki; Caski; CASKI
DR   BTO; BTO_0003109
DR   CLO; CLO_0002165
DR   CLO; CLO_0002201
DR   CLO; CLO_0050930
DR   EFO; EFO_0006549
DR   CLDB; cl603
DR   CLDB; cl604
DR   CLDB; cl605
DR   CLDB; cl4940
DR   AddexBio; C0008004/375
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1550
DR   ATCC; CRL-7915
DR   ATCC; CRM-CRL-1550
DR   BCRC; 60251
DR   BioSample; SAMN01821540
DR   BioSample; SAMN01821672
DR   BioSample; SAMN01821725
DR   BioSample; SAMN03473214
DR   cancercelllines; CVCL_1100
DR   CCRID; 1101HUM-PUMC000101
DR   CCRID; 1102HUM-NIFDC00093
DR   CCRID; 3101HUMTCHu137
DR   CCRID; 4201HUM-CCTCC00111
DR   CCTCC; GDC0111
DR   Cell_Model_Passport; SIDM00923
DR   ChEMBL-Cells; CHEMBL3308097
DR   ChEMBL-Targets; CHEMBL1075403
DR   CLS; 300145
DR   Cosmic; 687507
DR   Cosmic; 760221
DR   Cosmic; 809232
DR   Cosmic; 846182
DR   Cosmic; 877469
DR   Cosmic; 906824
DR   Cosmic; 925357
DR   Cosmic; 928904
DR   Cosmic; 1019307
DR   Cosmic; 1131519
DR   Cosmic; 1193033
DR   Cosmic; 1201775
DR   Cosmic; 1324211
DR   Cosmic; 1995364
DR   Cosmic; 2060797
DR   Cosmic; 2301538
DR   Cosmic; 2646655
DR   Cosmic; 2660195
DR   Cosmic; 2668297
DR   Cosmic; 2791017
DR   Cosmic; 2816212
DR   Cosmic-CLP; 906824
DR   DepMap; ACH-001336
DR   ECACC; 87020501
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   FANTOM5_SSTAR; 10431-106D8
DR   GDSC; 906824
DR   GEO; GSM29720
DR   GEO; GSM113861
DR   GEO; GSM226732
DR   GEO; GSM226867
DR   GEO; GSM253297
DR   GEO; GSM675733
DR   GEO; GSM685445
DR   GEO; GSM722572
DR   GEO; GSM722573
DR   GEO; GSM723053
DR   GEO; GSM723054
DR   GEO; GSM827309
DR   GEO; GSM1669667
DR   IARC_TP53; 21261
DR   IBRC; C10345
DR   ICLC; HTL98018
DR   IGRhCellID; CaSki%20GEO
DR   IZSLER; BS TCL 201
DR   JCRB; IFO50007
DR   KCB; KCB 2013034YJ
DR   KCLB; 21550
DR   LINCS_HMS; 50006
DR   LINCS_LDP; LCL-1541
DR   Lonza; 1669
DR   PharmacoDB; CaSki_158_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1100
DR   PubChem_Cell_line; CVCL_1100
DR   RCB; RCB1947
DR   TKG; TKG 0366
DR   Wikidata; Q54808287
RX   CelloPub=CLPUB00481;
RX   PubMed=867042;
RX   PubMed=2990217;
RX   PubMed=3029430;
RX   PubMed=3371749;
RX   PubMed=7751322;
RX   PubMed=9887230;
RX   PubMed=10423141;
RX   PubMed=15531914;
RX   PubMed=17311676;
RX   PubMed=17611311;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=21439369;
RX   PubMed=22412903;
RX   PubMed=24134916;
RX   PubMed=24201445;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-21.html
CC   Group: Space-flown cell line (cellonaut).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Virology: Contains from 100 to 800 copies of the HPV16 genome; some complete and others truncated.
CC   Doubling time: 3.2 days (PubMed=29156801).
CC   HLA typing: A*02:01,03:01; B*07:02,37:01; C*07:02,07:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln4079Ter (c.12235C>T); Zygosity=Heterozygous (Cosmic-CLP=906824; DepMap=ACH-001336).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (Cosmic-CLP=906824; DepMap=ACH-001336).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9887230).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.02%; Native American=0%; East Asian, North=1.86%; East Asian, South=0%; South Asian=0%; European, North=68.36%; European, South=28.76% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7915; true.
CC   Derived from site: Metastatic; Small intestine; UBERON=UBERON_0002108.
ST   Source(s): AddexBio=C0008004/375; ATCC=CRL-1550; CCRID; CLS=300145; Cosmic-CLP=906824; DepMap=ACH-001336; ECACC=87020501; JCRB=IFO50007; KCLB=21550; PubMed=25877200; PubMed=29156801; RCB=RCB1947; TKG=TKG 0366
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,12
ST   D16S539: 11,12
ST   D18S51: 17
ST   D19S433: 15,16
ST   D21S11: 30
ST   D2S1338: 21
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 8,11
ST   D8S1179: 15
ST   FGA: 21
ST   Penta D: 10
ST   Penta E: 5
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 44
//
RX   PubMed=3029430; DOI=10.1128/JVI.61.4.962-971.1987; PMCID=PMC254051;
RA   Baker, Carl C.
RA   Phelps, William C.
RA   Lindgren, Valerie
RA   Braun, Michael J.
RA   Gonda, Matthew A.
RA   Howley, Peter Maxwell
RT   "Structural and transcriptional analysis of human papillomavirus type
RT   16 sequences in cervical carcinoma cell lines.";
RL   J. Virol. 61:962-971(1987).
//
RX   PubMed=22412903; DOI=10.1371/journal.pone.0032667; PMCID=PMC3296745;
RA   Vazquez-Mena, Oscar
RA   Medina-Martinez, Ingrid
RA   Juarez-Torres, Eligia
RA   Barron, Valeria
RA   Espinosa, Ana
RA   Villegas-Sepulveda, Nicolas
RA   Gomez-Laguna, Laura
RA   Nieto-Martinez, Karem
RA   Orozco, Lorena Sofia
RA   Roman-Bassaure, Edgar
RA   Munoz Cortez, Sergio
RA   Borges Ibanez, Manuel
RA   Venegas-Vega, Carlos Alberto
RA   Guardado-Estrada, Mariano
RA   Rangel-Lopez, Angelica
RA   Kofman, Susana
RA   Berumen, Jaime
RT   "Amplified genes may be overexpressed, unchanged, or downregulated in
RT   cervical cancer cell lines.";
RL   PLoS ONE 7:e32667.1-e32667.17(2012).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=2990217; PMCID=PMC1888002;
RA   Yee, Carole
RA   Krishnan-Hewlett, Indira
RA   Baker, Carl C.
RA   Schlegel, Richard
RA   Howley, Peter Maxwell
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=7751322; DOI=10.1007/BF01366967;
RA   Rantanen, Virpi
RA   Grenman, Seija E.
RA   Kulmala, Jarmo
RA   Grenman, Reidar
RT   "The intrinsic radiosensitivity and sublethal damage repair capacity
RT   of five cervical carcinoma cell lines tested with the 96-well-plate
RT   assay.";
RL   J. Cancer Res. Clin. Oncol. 121:230-234(1995).
//
RX   CelloPub=CLPUB00481;
RA   Kuno, Haruhiko
RA   Yoshida, Touho
RT   "Detection of human papillomavirus types 16, 18, and 33 in cell lines
RT   derived from human genital organs by polymerase chain reaction.";
RL   Res. Commun. Inst. Ferment. 18:6-12(1997).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7;
RA   Grenman, Seija E.
RA   Shapira, Amnon
RA   Carey, Thomas E.
RT   "In vitro response of cervical cancer cell lines CaSki, HeLa, and
RT   ME-180 to the antiestrogen tamoxifen.";
RL   Gynecol. Oncol. 30:228-238(1988).
//
RX   PubMed=17311676; DOI=10.1186/1471-2164-8-53; PMCID=PMC1805756;
RA   Kloth, Judith N.
RA   Oosting, Jan
RA   van Wezel, Tom
RA   Szuhai, Karoly
RA   Knijnenburg, Jeroen
RA   Gorter, Arko
RA   Kenter, Gemma G.
RA   Fleuren, Gert Jan
RA   Jordanova, Ekaterina S.
RT   "Combined array-comparative genomic hybridization and
RT   single-nucleotide polymorphism-loss of heterozygosity analysis reveals
RT   complex genetic alterations in cervical cancer.";
RL   BMC Genomics 8:53.1-53.13(2007).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus, Stefan E.
RA   Schwarz, Elisabeth
RA   Lohrey, Claudia
RA   Zapatka, Marc
RA   Landsberg, Stephanie
RA   Hahn, Stephan A.
RA   Schmidt, Dietmar
RA   Dienes, Hans-Peter
RA   Schmiegel, Wolff Helmut
RA   Schwarte-Waldhoff, Irmgard
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725;
RA   Meissner, John D.
RT   "Nucleotide sequences and further characterization of human
RT   papillomavirus DNA present in the CaSki, SiHa and HeLa cervical
RT   carcinoma cell lines.";
RL   J. Gen. Virol. 80:1725-1733(1999).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223;
RA   McCormack, Amanda
RA   Fan, Jiang-Lan
RA   Duesberg, Max
RA   Bloomfield, Mathew
RA   Fiala, Christian
RA   Duesberg, Peter Heinz
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen, Virpi
RA   Grenman, Seija E.
RA   Kurvinen, Kaisa
RA   Hietanen, Sakari H.
RA   Raitanen, Misa
RA   Syrjanen, Stina M.
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003;
RA   Schmitt, Markus
RA   Pawlita, Michael
RT   "The HPV transcriptome in HPV16 positive cell lines.";
RL   Mol. Cell. Probes 25:108-113(2011).
//
RX   PubMed=867042; DOI=10.1126/science.867042;
RA   Pattillo, Roland Anthony
RA   Hussa, Robert O.
RA   Story, Michael T.
RA   Ruckert, Anna C.F.
RA   Shalaby, M. Refaat
RA   Mattingly, Richard F.
RT   "Tumor antigen and human chorionic gonadotropin in CaSki cells: a new
RT   epidermoid cervical cancer cell line.";
RL   Science 196:1456-1458(1977).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=17611311;
RA   Yang, Cheng
RA   Li, Guan-Cheng
RA   Li, Yue-Hui
RA   Hu, Jin-Yue
RA   Xiao, Yan
RA   Zhang, Zhi-Jie
RT   "Biological properties of Caski cell lines induced by exposing to the
RT   space environment.";
RL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:380-386(2007).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410;
RA   Akagi, Keiko
RA   Li, Jing-Feng
RA   Broutian, Tatevik R.
RA   Padilla-Nash, Hesed Maria
RA   Xiao, Wei-Hong
RA   Jiang, Bo
RA   Rocco, James W.
RA   Teknos, Theodoros Null
RA   Kumar, Bhavna
RA   Wangsa, Danny
RA   He, Dan
RA   Ried, Thomas
RA   Symer, David E.
RA   Gillison, Maura Lianne
RT   "Genome-wide analysis of HPV integration in human cancers reveals
RT   recurrent, focal genomic instability.";
RL   Genome Res. 24:185-199(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//