ID   C-4-II
AC   CVCL_1095
SY   C-4 II; C-4II; C4 II; C4II
DR   CLO; CLO_0002126
DR   EFO; EFO_0002123
DR   CLDB; cl571
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ATCC; CRL-1595
DR   ATCC; CRL-7914
DR   BioSample; SAMN03471403
DR   cancercelllines; CVCL_1095
DR   Cell_Model_Passport; SIDM00906
DR   ChEMBL-Cells; CHEMBL3308712
DR   ChEMBL-Targets; CHEMBL1075400
DR   Cosmic; 760218
DR   Cosmic; 809230
DR   Cosmic; 910553
DR   DepMap; ACH-001335
DR   ECACC; 88102701
DR   GEO; GSM675732
DR   GEO; GSM685437
DR   IARC_TP53; 21202
DR   IGRhCellID; C4II
DR   LINCS_LDP; LCL-1302
DR   Progenetix; CVCL_1095
DR   PubChem_Cell_line; CVCL_1095
DR   Wikidata; Q54799745
RX   PubMed=833871;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=5796380;
RX   PubMed=6935474;
RX   PubMed=13863218;
RX   PubMed=14114965;
RX   PubMed=15531914;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=24134916;
RX   PubMed=29156801;
RX   PubMed=35692560;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Virology: Contains a complete HPV18 genome.
CC   Doubling time: 2.4 days (PubMed=29156801).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; CRL-7914; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC=CRL-1595; DepMap=ACH-001335; ECACC=88102701; PubMed=29156801
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 14
ST   D19S433: 13,14
ST   D21S11: 29,30
ST   D2S1338: 23
ST   D3S1358: 16,17
ST   D5S818: 9,11
ST   D7S820: 10,11
ST   D8S1179: 14,15
ST   FGA: 25
ST   Penta D: 9,13
ST   Penta E: 19
ST   TH01: 9,9.3
ST   TPOX: 10,11
ST   vWA: 14
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2253 ! C-4-I
SX   Female
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=2990217; PMCID=PMC1888002;
RA   Yee, Carole
RA   Krishnan-Hewlett, Indira
RA   Baker, Carl C.
RA   Schlegel, Richard
RA   Howley, Peter Maxwell
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh, Jorgen
RA   Wright, William C.
RA   Loveless, James D.
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus, Stefan E.
RA   Schwarz, Elisabeth
RA   Lohrey, Claudia
RA   Zapatka, Marc
RA   Landsberg, Stephanie
RA   Hahn, Stephan A.
RA   Schmidt, Dietmar
RA   Dienes, Hans-Peter
RA   Schmiegel, Wolff Helmut
RA   Schwarte-Waldhoff, Irmgard
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=13863218; DOI=10.1093/jnci/28.3.605;
RA   Auersperg, Nelly
RA   Hawryluk, Annette Patricia
RT   "Chromosome observations on three epithelial-cell cultures derived
RT   from carcinomas of the human cervix.";
RL   J. Natl. Cancer Inst. 28:605-627(1962).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225;
RA   de Lourdes Zuniga-Martinez, Ma
RA   Lopez-Mendoza, Carlos Miguel
RA   Tenorio-Salazar, Jared
RA   Garcia-Carranca, Alejandro Manuel
RA   Cerbon-Cervantes, Marco Antonio
RA   Alcantara-Quintana, Luz Eugenia
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223;
RA   McCormack, Amanda
RA   Fan, Jiang-Lan
RA   Duesberg, Max
RA   Bloomfield, Mathew
RA   Fiala, Christian
RA   Duesberg, Peter Heinz
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=5796380; DOI=10.1093/jnci/43.1.151;
RA   Auersperg, Nelly
RT   "Histogenetic behavior of tumors. I. Morphologic variation in vitro
RT   and in vivo of two related human carcinoma cell lines.";
RL   J. Natl. Cancer Inst. 43:151-173(1969).
//
RX   PubMed=14114965; DOI=10.1093/jnci/32.1.135;
RA   Auersperg, Nelly
RT   "Long-term cultivation of hypodiploid human tumor cells.";
RL   J. Natl. Cancer Inst. 32:135-163(1964).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright, William C.
RA   Daniels, Walter P.
RA   Fogh, Jorgen
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//