ID   C-4-II
AC   CVCL_1095
SY   C-4 II; C-4II; C4 II; C4II
DR   CLO; CLO_0002126
DR   EFO; EFO_0002123
DR   CLDB; cl571
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ATCC; CRL-1595
DR   ATCC; CRL-7914
DR   BioSample; SAMN03471403
DR   cancercelllines; CVCL_1095
DR   Cell_Model_Passport; SIDM00906
DR   ChEMBL-Cells; CHEMBL3308712
DR   ChEMBL-Targets; CHEMBL1075400
DR   Cosmic; 760218
DR   Cosmic; 809230
DR   Cosmic; 910553
DR   DepMap; ACH-001335
DR   ECACC; 88102701
DR   GEO; GSM675732
DR   GEO; GSM685437
DR   IARC_TP53; 21202
DR   IGRhCellID; C4II
DR   LINCS_LDP; LCL-1302
DR   Progenetix; CVCL_1095
DR   PubChem_Cell_line; CVCL_1095
DR   Wikidata; Q54799745
RX   PubMed=833871;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=5796380;
RX   PubMed=6935474;
RX   PubMed=13863218;
RX   PubMed=14114965;
RX   PubMed=15531914;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=24134916;
RX   PubMed=29156801;
RX   PubMed=35692560;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Virology: Contains a complete HPV18 genome.
CC   Doubling time: 2.4 days (PubMed=29156801).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: ATCC; CRL-7914; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC=CRL-1595; DepMap=ACH-001335; ECACC=88102701; PubMed=29156801
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 14
ST   D19S433: 13,14
ST   D21S11: 29,30
ST   D2S1338: 23
ST   D3S1358: 16,17
ST   D5S818: 9,11
ST   D7S820: 10,11
ST   D8S1179: 14,15
ST   FGA: 25
ST   Penta D: 9,13
ST   Penta E: 19
ST   TH01: 9,9.3
ST   TPOX: 10,11
ST   vWA: 14
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2253 ! C-4-I
SX   Female
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 33
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=2990217; PMCID=PMC1888002;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=5796380; DOI=10.1093/jnci/43.1.151;
RA   Auersperg N.;
RT   "Histogenetic behavior of tumors. I. Morphologic variation in vitro
RT   and in vivo of two related human carcinoma cell lines.";
RL   J. Natl. Cancer Inst. 43:151-173(1969).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=13863218; DOI=10.1093/jnci/28.3.605;
RA   Auersperg N., Hawryluk A.P.;
RT   "Chromosome observations on three epithelial-cell cultures derived
RT   from carcinomas of the human cervix.";
RL   J. Natl. Cancer Inst. 28:605-627(1962).
//
RX   PubMed=14114965; DOI=10.1093/jnci/32.1.135;
RA   Auersperg N.;
RT   "Long-term cultivation of hypodiploid human tumor cells.";
RL   J. Natl. Cancer Inst. 32:135-163(1964).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223;
RA   McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.H.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225;
RA   de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J.,
RA   Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.;
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//