ID   BONNA-12
AC   CVCL_1090
SY   Bonna-12; BONNA12; Bonna12
DR   CLO; CLO_0002014
DR   CLDB; cl473
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473418
DR   cancercelllines; CVCL_1090
DR   Cell_Model_Passport; SIDM00984
DR   Cosmic; 906695
DR   Cosmic; 2690006
DR   Cosmic; 2756295
DR   Cosmic-CLP; 906695
DR   DepMap; ACH-001452
DR   DSMZ; ACC-150
DR   DSMZCellDive; ACC-150
DR   EGA; EGAS00001000978
DR   GEO; GSM1669627
DR   IARC_TP53; 21196
DR   PharmacoDB; BONNA12_106_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54797948
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1313127;
RX   PubMed=20164919;
RX   PubMed=20454443;
RX   PubMed=22653958;
RX   PubMed=27397505;
RX   PubMed=27463354;
RX   PubMed=29989027;
RX   PubMed=30894373;
RX   PubMed=31160637;
RX   PubMed=35839778;
CC   Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 36-48 hours (PubMed=27463354); ~50-60 hours (DSMZ=ACC-150).
CC   HLA typing: A*11:01:01,68:01:02; B*35:01:01,40:01:02; C*03:04:01,04:01:01; DPA1*01:03:01,01:03:01; DPB1*03:01:01,02:01:02; DQA1*01:03:01,01:01:01; DQB1*05:01:01,06:03:01; DRA*01:01:01,01:02:02; DRB1*01:01:01,13:01:01 (DSMZCellDive=ACC-150).
CC   Karyotypic information: Has lost chromosome Y.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Thr2466Met (c.7397C>T); ClinVar=VCV000241169; Zygosity=Heterozygous (PubMed=29989027; Cosmic-CLP=906695; DepMap=ACH-001452).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.35%; Native American=0%; East Asian, North=1.04%; East Asian, South=0%; South Asian=0%; European, North=71.7%; European, South=26.91% (PubMed=30894373).
CC   Derived from site: Metastatic; Spleen; UBERON=UBERON_0002106.
ST   Source(s): Cosmic-CLP=906695; DepMap=ACH-001452; DSMZ=ACC-150
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,14
ST   D16S539: 11,12 (DSMZ=ACC-150)
ST   D16S539: 12 (Cosmic-CLP=906695; DepMap=ACH-001452)
ST   D18S51: 13 (DSMZ=ACC-150)
ST   D18S51: 14 (DepMap=ACH-001452)
ST   D19S433: 14,17
ST   D21S11: 30,31.2
ST   D2S1338: 19
ST   D3S1358: 14,17
ST   D5S818: 9,14
ST   D7S820: 8,10
ST   D8S1179: 10,13
ST   FGA: 18,22
ST   Penta D: 9,11 (DSMZ=ACC-150)
ST   Penta D: 9,12 (DepMap=ACH-001452)
ST   Penta E: 10,11 (DSMZ=ACC-150)
ST   Penta E: 11 (DepMap=ACH-001452)
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C7402; Hairy cell leukemia
DI   ORDO; Orphanet_58017; Classic hairy cell leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
//
RX   PubMed=22653958; DOI=10.1182/blood-2011-12-400374;
RA   Tiacci, Enrico
RA   Pucciarini, Alessandra
RA   Bigerna, Barbara
RA   Pettirossi, Valentina
RA   Strozzini, Francesca
RA   Martelli, Maria Paola
RA   Tabarrini, Alessia
RA   Drexler, Hans Gunther
RA   Falini, Brunangelo
RT   "Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M,
RT   and HC-1 questions their origin from hairy cell leukemia.";
RL   Blood 119:5332-5333(2012).
//
RX   PubMed=29989027; DOI=10.18632/oncotarget.25601; PMCID=PMC6034755;
RA   Maitre, Elsa
RA   Bertrand, Philippe
RA   Maingonnat, Catherine
RA   Viailly, Pierre-Julien
RA   Wiber, Margaux
RA   Naguib, Dina
RA   Salaun, Veronique
RA   Cornet, Edouard
RA   Damaj, Gandhi
RA   Sola, Brigitte
RA   Jardin, Fabrice
RA   Troussard, Xavier
RT   "New generation sequencing of targeted genes in the classical and the
RT   variant form of hairy cell leukemia highlights mutations in epigenetic
RT   regulation genes.";
RL   Oncotarget 9:28866-28876(2018).
//
RX   PubMed=27463354; DOI=10.3109/10428199109067637;
RA   Wientjens, Gert-Jan H.M.
RA   Jansen, Joop H.
RA   Wessels, Hans W.
RA   Kibbelaar, Robert E.
RA   Beverstock, Geoffrey C.
RA   Brederoo, Pieter
RA   Kluin-Nelemans, Hanneke Cornelia
RT   "Characterization of a new human B cell line (Bonna-12) with trisomy 9
RT   and trisomy 12 chromosomal abnormality.";
RL   Leuk. Lymphoma 5:415-422(1991).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=1313127;
RA   Kluin-Nelemans, Hanneke Cornelia
RA   Wientjens, Gert-Jan H.M.
RA   Jansen, Joop H.
RT   "Establishment of a new human B-cell line (BONNA-12) with trisomy 9
RT   and trisomy 12 chromosomal abnormality.";
RL   Leukemia 6:158-158(1992).
//