ID A-704 AC CVCL_1065 SY A.704; A704 DR BTO; BTO_0004583 DR CLO; CLO_0001546 DR CLO; CLO_0001609 DR CLO; CLO_0001610 DR CLDB; cl167 DR CLDB; cl168 DR CLDB; cl170 DR CLDB; cl5026 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-7911 DR ATCC; HTB-45 DR BioSample; SAMN03471120 DR BioSample; SAMN03472920 DR BioSample; SAMN10987988 DR cancercelllines; CVCL_1065 DR Cell_Model_Passport; SIDM00849 DR ChEMBL-Cells; CHEMBL3307650 DR ChEMBL-Targets; CHEMBL614567 DR CLS; 300217 DR Cosmic; 687938 DR Cosmic; 910920 DR Cosmic; 979707 DR Cosmic; 982279 DR Cosmic; 1995339 DR Cosmic; 2520641 DR Cosmic-CLP; 910920 DR DepMap; ACH-000429 DR ECACC; 93020513 DR EGA; EGAS00001000978 DR GDSC; 910920 DR GEO; GSM374459 DR GEO; GSM886860 DR GEO; GSM887925 DR GEO; GSM1669591 DR IARC_TP53; 21169 DR IARC_TP53; 27550 DR ICLC; HTL95007 DR IZSLER; BS TCL 117 DR KCLB; 30045 DR LiGeA; CCLE_470 DR LINCS_LDP; LCL-1762 DR NCI-DTP; A704 DR PharmacoDB; A704_50_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1065 DR PubChem_Cell_line; CVCL_1065 DR Wikidata; Q54606061 RX PubMed=77569; RX PubMed=450131; RX PubMed=571047; RX PubMed=3335022; RX PubMed=3518877; RX PubMed=4357758; RX PubMed=6220172; RX PubMed=6244232; RX PubMed=6256643; RX PubMed=6500159; RX PubMed=6825208; RX PubMed=7591954; RX PubMed=20164919; RX PubMed=22460905; RX PubMed=22949125; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=28489074; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). CC Population: African American. CC HLA typing: A*01,03; B*08,12 (PubMed=77569). CC HLA typing: A*34:02,74:01; B*35:01,44:03; C*04:01,04:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*11:02,15:03 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-low) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Asp (c.376T>G); ClinVar=VCV000265333; Zygosity=Heterozygous (Cosmic-CLP=910920). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Arg (c.403T>C); ClinVar=VCV000376560; Zygosity=Heterozygous (Cosmic-CLP=910920). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu258Ter (c.772G>T); ClinVar=VCV000486557; Zygosity=Heterozygous (Cosmic-CLP=910920). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=71.07%; Native American=0%; East Asian, North=6.26%; East Asian, South=0%; South Asian=0%; European, North=2.53%; European, South=20.13% (PubMed=30894373). CC Discontinued: ATCC; CRL-7911; true. CC Derived from site: In situ; Kidney; UBERON=UBERON_0002113. CC Cell type: Epithelial cell of kidney; CL=CL_0002518. ST Source(s): ATCC=HTB-45; CLS=300217; Cosmic-CLP=910920; ECACC=93020513; IZSLER=BS TCL 117; KCLB=30045; PubMed=25877200 ST Amelogenin: X,Y ST CSF1PO: 7,8 ST D13S317: 8 ST D16S539: 12,13 ST D18S51: 16,17 ST D19S433: 13 ST D21S11: 28,32 ST D2S1338: 16,21 ST D3S1358: 15 ST D5S818: 10,11 ST D7S820: 10 ST D8S1179: 13,15 ST FGA: 22,23 ST Penta D: 2.2,11 ST Penta E: 8,17 ST TH01: 7 (PubMed=25877200) ST TH01: 7,9 (ATCC=HTB-45; CLS=300217; Cosmic-CLP=910920; ECACC=93020513; IZSLER=BS TCL 117; KCLB=30045) ST TPOX: 11 ST vWA: 14,18 DI NCIt; C9385; Renal cell carcinoma DI ORDO; Orphanet_217071; Renal cell carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 78Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 // RX PubMed=6500159; DOI=10.1159/000163283; RA Gershwin, Merrill Eric RA Lentz, Daniel RA Owens, Robert B. RT "Relationship between karyotype of tissue culture lines and RT tumorigenicity in nude mice."; RL Exp. Cell Biol. 52:361-370(1984). // RX PubMed=450131; DOI=10.1038/279797a0; RA Day, Rufus S. 3rd RA Ziolkowski, Chuck H.J. RT "Human brain tumour cell strains with deficient host-cell reactivation RT of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5."; RL Nature 279:797-799(1979). // RX PubMed=6220172; RA Dracopoli, Nicholas C. RA Fogh, Jorgen RT "Polymorphic enzyme analysis of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 70:469-476(1983). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=3335022; RA Alley, Michael Curtis RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=6825208; DOI=10.1093/carcin/4.2.199; RA Yarosh, Daniel B. RA Foote, Robert S. RA Mitra, Sankar RA Day, Rufus S. 3rd RT "Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- RT human tumor cell strains."; RL Carcinogenesis 4:199-205(1983). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=571047; RA Fogh, Jorgen RT "Cultivation, characterization, and identification of human tumor RT cells with emphasis on kidney, testis, and bladder tumors."; RL Natl. Cancer Inst. Monogr. 49:5-9(1978). // RX PubMed=6244232; RA Williams, Richard D. RT "Human urologic cancer cell lines."; RL Invest. Urol. 17:359-363(1980). // RX PubMed=22949125; DOI=10.1002/ijc.27822; RA Pawlowski, Rafal RA Muhl, Sarah M. RA Sulser, Tullio RA Krek, Wilhelm RA Moch, Holger RA Schraml, Peter RT "Loss of PBRM1 expression is associated with renal cell carcinoma RT progression."; RL Int. J. Cancer 132:E11-E17(2013). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. 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RA Hakimi, Abraham Ari RT "Analysis of renal cancer cell lines from two major resources enables RT genomics-guided cell line selection."; RL Nat. Commun. 8:15165.1-15165.10(2017). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=6256643; DOI=10.1038/288724a0; RA Day, Rufus S. 3rd RA Ziolkowski, Chuck H.J. RA Scudiero, Dominic A. RA Meyer, Sharon A. RA Lubiniecki, Anthony S. RA Girardi, Anthony Joseph RA Galloway, Sheila Margaret RA Bynum, Gaither D. RT "Defective repair of alkylated DNA by human tumour and RT SV40-transformed human cell strains."; RL Nature 288:724-727(1980). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=7591954; DOI=10.1111/j.1349-7006.1995.tb03087.x; PMCID=PMC5920923; RA Kinoshita, Hidefumi RA Yamada, Hitoshi RA Ogawa, Osamu RA Kakehi, Yoshiyuki RA Osaka, Mitsuhiko RA Nakamura, Eijiro RA Mishina, Mutsuki RA Habuchi, Tomonori RA Takahashi, Rei RA Sugiyama, Taketoshi RA Yoshida, Osamu RT "Contribution of chromosome 9p21-22 deletion to the progression of RT human renal cell carcinoma."; RL Jpn. J. Cancer Res. 86:795-799(1995). // RX PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x; RA Espmark, Jons Ake RA Ahlqvist-Roth, Lena RA Sarne, Lena RA Persson, Anita RT "Tissue typing of cells in culture. III. HLA antigens of established RT human cell lines. Attempts at typing by the mixed hemadsorption RT technique."; RL Tissue Antigens 11:279-286(1978). // RX PubMed=4357758; DOI=10.1093/jnci/51.5.1417; RA Giard, Donald J. RA Aaronson, Stuart A. RA Todaro, George J. RA Arnstein, Paul RA Kersey, John H. RA Dosik, Harvey RA Parks, Wade P. RT "In vitro cultivation of human tumors: establishment of cell lines RT derived from a series of solid tumors."; RL J. Natl. Cancer Inst. 51:1417-1423(1973). //