ID   A-388
AC   CVCL_1063
SY   A388
DR   CLO; CLO_0001584
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-7905
DR   BioSample; SAMN03471118
DR   cancercelllines; CVCL_1063
DR   Cell_Model_Passport; SIDM00794
DR   ChEMBL-Cells; CHEMBL3308159
DR   ChEMBL-Targets; CHEMBL2366355
DR   Cosmic; 688037
DR   Cosmic; 910697
DR   Cosmic; 1995333
DR   Cosmic-CLP; 910697
DR   DepMap; ACH-001442
DR   EGA; EGAS00001000978
DR   GDSC; 910697
DR   GEO; GSM1669583
DR   IARC_TP53; 21164
DR   LINCS_LDP; LCL-1342
DR   PharmacoDB; A388_43_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1063
DR   Wikidata; Q54606033
RX   PubMed=327080;
RX   PubMed=375235;
RX   PubMed=833871;
RX   PubMed=1255758;
RX   PubMed=1358434;
RX   PubMed=3518877;
RX   PubMed=4357758;
RX   PubMed=6173755;
RX   PubMed=6256643;
RX   PubMed=6954533;
RX   PubMed=20164919;
RX   PubMed=22282976;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-and-growth-of-a388-crl-7905
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg832Cys (c.2494C>T); ClinVar=VCV000936373; Zygosity=Heterozygous (ATCC=CRL-7905; DepMap=ACH-001442).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (ATCC=CRL-7905; DepMap=ACH-001442).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (ATCC=CRL-7905; Cosmic-CLP=910697; DepMap=ACH-001442).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=4.06%; Native American=0.32%; East Asian, North=3.84%; East Asian, South=0%; South Asian=0%; European, North=50.76%; European, South=41.03% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ATCC=CRL-7905; Cosmic-CLP=910697; DepMap=ACH-001442
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D19S433: 12,15
ST   D21S11: 28,30
ST   D2S1338: 18,25
ST   D3S1358: 13
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 12,13
ST   FGA: 22
ST   Penta D: 7,10
ST   Penta E: 11,13
ST   TH01: 9,9.3
ST   TPOX: 8,9
ST   vWA: 17,18
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   86Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 40
CH   CVCL_ZF53 ! A388.6TG.c2
//
RX   PubMed=1255758; DOI=10.1093/jnci/56.2.245;
RA   Gonda, Matthew A.
RA   Aaronson, Stuart A.
RA   Ellmore, Nelson Wayne
RA   Zeve, Victor H.
RA   Nagashima, Kunio
RT   "Ultrastructural studies of surface features of human normal and tumor
RT   cells in tissue culture by scanning and transmission electron
RT   microscopy.";
RL   J. Natl. Cancer Inst. 56:245-263(1976).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh, Jorgen
RA   Wright, William C.
RA   Loveless, James D.
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=22282976; DOI=10.1093/carcin/1.1.21;
RA   Day, Rufus S. 3rd
RA   Ziolkowski, Chuck H.J.
RA   Scudiero, Dominic A.
RA   Meyer, Sharon A.
RA   Mattern, Michael R.
RT   "Human tumor cell strains defective in the repair of alkylation
RT   damage.";
RL   Carcinogenesis 1:21-32(1980).
//
RX   PubMed=375235; DOI=10.1073/pnas.76.3.1288; PMCID=PMC383236;
RA   Sherwin, Stephen A.
RA   Sliski, Ann H.
RA   Todaro, George J.
RT   "Human melanoma cells have both nerve growth factor and nerve growth
RT   factor-specific receptors on their cell surfaces.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979).
//
RX   PubMed=4357758; DOI=10.1093/jnci/51.5.1417;
RA   Giard, Donald J.
RA   Aaronson, Stuart A.
RA   Todaro, George J.
RA   Arnstein, Paul
RA   Kersey, John H.
RA   Dosik, Harvey
RA   Parks, Wade P.
RT   "In vitro cultivation of human tumors: establishment of cell lines
RT   derived from a series of solid tumors.";
RL   J. Natl. Cancer Inst. 51:1417-1423(1973).
//
RX   PubMed=6256643; DOI=10.1038/288724a0;
RA   Day, Rufus S. 3rd
RA   Ziolkowski, Chuck H.J.
RA   Scudiero, Dominic A.
RA   Meyer, Sharon A.
RA   Lubiniecki, Anthony S.
RA   Girardi, Anthony Joseph
RA   Galloway, Sheila Margaret
RA   Bynum, Gaither D.
RT   "Defective repair of alkylated DNA by human tumour and
RT   SV40-transformed human cell strains.";
RL   Nature 288:724-727(1980).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=6173755; DOI=10.1038/295116a0;
RA   Eva, Alessandra
RA   Robbins, Keith Cranston
RA   Andersen, Philip Roger
RA   Srinivasan, Alagarsamy
RA   Tronick, Steven R.
RA   Reddy, E. Premkumar
RA   Ellmore, Nelson Wayne
RA   Galen, Angela T.
RA   Lautenberger, James Allen
RA   Papas, Takis S.
RA   Westin, Eric H.
RA   Wong-Staal, Flossie
RA   Gallo, Robert Charles
RA   Aaronson, Stuart A.
RT   "Cellular genes analogous to retroviral onc genes are transcribed in
RT   human tumour cells.";
RL   Nature 295:116-119(1982).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157;
RA   Westin, Eric H.
RA   Gallo, Robert Charles
RA   Arya, Suresh K.
RA   Eva, Alessandra
RA   Souza, Lawrence M.
RA   Baluda, Marcel Albert
RA   Aaronson, Stuart A.
RA   Wong-Staal, Flossie
RT   "Differential expression of the amv gene in human hematopoietic
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
//
RX   PubMed=1358434;
RA   Conway, Kathleen
RA   Morgan, David
RA   Phillips, Karen K.
RA   Yuspa, Stuart Howard
RA   Weissman, Bernard E.
RT   "Tumorigenic suppression of a human cutaneous squamous cell carcinoma
RT   cell line in the nude mouse skin graft assay.";
RL   Cancer Res. 52:6487-6495(1992).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh, Jorgen
RA   Fogh, Jens M.
RA   Orfeo, Thomas
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//