ID   IOSE11
AC   CVCL_0T68
SY   iOSE11; IOE11; Immortalized Ovarian Surface Epithelial cells 11
DR   GEO; GSM1663032
DR   GEO; GSM1663033
DR   GEO; GSM1663034
DR   GEO; GSM1663035
DR   GEO; GSM1663036
DR   GEO; GSM1663037
DR   GEO; GSM1663038
DR   GEO; GSM1663039
DR   GEO; GSM2889281
DR   GEO; GSM2889282
DR   GEO; GSM2889283
DR   GEO; GSM2889284
DR   GEO; GSM2889285
DR   GEO; GSM2889286
DR   Wikidata; Q54897912
RX   PubMed=20360942;
RX   PubMed=21859834;
RX   PubMed=25204737;
RX   PubMed=25804953;
RX   PubMed=29844388;
RX   PubMed=30487138;
RX   PubMed=34253763;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K4me1.
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: STR profile from personal communication of Monteiro, Alvaro N.A.
CC   Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 10,11
ST   D18S51: 13,14
ST   D21S11: 29
ST   D3S1358: 16,17
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 11,15
ST   FGA: 20,22
ST   Penta D: 8,16
ST   Penta E: 14,18
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 14
//
RX   PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739;
RA   Lawrenson K., Grun B., Benjamin E., Jacobs I.J., Dafou D.,
RA   Gayther S.A.;
RT   "Senescent fibroblasts promote neoplastic transformation of partially
RT   transformed ovarian epithelial cells in a three-dimensional model of
RT   early stage ovarian cancer.";
RL   Neoplasia 12:317-325(2010).
//
RX   PubMed=21859834; DOI=10.1093/carcin/bgr140;
RA   Lawrenson K., Sproul D., Grun B., Notaridou M., Benjamin E.,
RA   Jacobs I.J., Dafou D., Sims A.H., Gayther S.A.;
RT   "Modelling genetic and clinical heterogeneity in epithelial ovarian
RT   cancers.";
RL   Carcinogenesis 32:1540-1549(2011).
//
RX   PubMed=25204737; DOI=10.1002/ijc.29197;
RA   Lawrenson K., Mhawech-Fauceglia P., Worthington J., Spindler T.J.,
RA   O'Brien D., Lee J.M., Spain G., Sharifian M., Wang G.-S., Darcy K.M.,
RA   Pejovic T., Sowter H.M., Timms J.F., Gayther S.A.;
RT   "Identification of novel candidate biomarkers of epithelial ovarian
RT   cancer by profiling the secretomes of three-dimensional genetic models
RT   of ovarian carcinogenesis.";
RL   Int. J. Cancer 137:1806-1817(2015).
//
RX   PubMed=25804953; DOI=10.1093/hmg/ddv101; PMCID=PMC4459387;
RA   Coetzee S.G., Shen H.C., Hazelett D.J., Lawrenson K.,
RA   Kuchenbaecker K., Tyrer J.P., Rhie S.K., Levanon K., Karst A.M.,
RA   Drapkin R.I., Ramus S.J., Couch F.J., Offit K., Chenevix-Trench G.,
RA   Monteiro A.N.A., Antoniou A., Freedman M.L., Coetzee G.A.,
RA   Pharoah P.D.P., Noushmehr H., Gayther S.A.;
RG   Consortium of Investigators of Modifiers of BRCA1/2;
RG   Ovarian Cancer Association Consortium;
RT   "Cell-type-specific enrichment of risk-associated regulatory elements
RT   at ovarian cancer susceptibility loci.";
RL   Hum. Mol. Genet. 24:3595-3607(2015).
//
RX   PubMed=29844388; DOI=10.1038/s41598-018-26670-4; PMCID=PMC5974302;
RA   Gjyshi A., Dash S., Cen L., Cheng C.-H., Zhang C.-M., Yoder S.J.,
RA   Teer J.K., Armaiz-Pena G.N., Monteiro A.N.A.;
RT   "Early transcriptional response of human ovarian and fallopian tube
RT   surface epithelial cells to norepinephrine.";
RL   Sci. Rep. 8:8291-8291(2018).
//
RX   PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979;
RA   Buckley M.A., Woods N.T., Tyrer J.P., Mendoza-Fandino G.,
RA   Lawrenson K., Hazelett D.J., Najafabadi H.S., Gjyshi A.,
RA   Carvalho R.S., Lyra P.C. Jr., Coetzee S.G., Shen H.C., Yang A.W.,
RA   Earp M.A., Yoder S.J., Risch H., Chenevix-Trench G., Ramus S.J.,
RA   Phelan C.M., Coetzee G.A., Noushmehr H., Hughes T.R., Sellers T.A.,
RA   Goode E.L., Pharoah P.D.P., Gayther S.A., Monteiro A.N.A.;
RT   "Functional analysis and fine mapping of the 9p22.2 ovarian cancer
RT   susceptibility locus.";
RL   Cancer Res. 79:467-481(2019).
//
RX   PubMed=34253763; DOI=10.1038/s41598-021-93506-z; PMCID=PMC8275603;
RA   Dash S., Yoder S.J., Mesa T., Smith A., Cen L., Eschrich S.A.,
RA   Armaiz-Pena G.N., Monteiro A.N.A.;
RT   "Effects of long-term norepinephrine treatment on normal immortalized
RT   ovarian and fallopian tube cells.";
RL   Sci. Rep. 11:14334.1-14334.12(2021).
//