ID   IOSE11
AC   CVCL_0T68
SY   iOSE11; IOE11; Immortalized Ovarian Surface Epithelial cells 11
DR   GEO; GSM1663032
DR   GEO; GSM1663033
DR   GEO; GSM1663034
DR   GEO; GSM1663035
DR   GEO; GSM1663036
DR   GEO; GSM1663037
DR   GEO; GSM1663038
DR   GEO; GSM1663039
DR   GEO; GSM2889281
DR   GEO; GSM2889282
DR   GEO; GSM2889283
DR   GEO; GSM2889284
DR   GEO; GSM2889285
DR   GEO; GSM2889286
DR   Wikidata; Q54897912
RX   PubMed=20360942;
RX   PubMed=21859834;
RX   PubMed=25204737;
RX   PubMed=25804953;
RX   PubMed=29844388;
RX   PubMed=30487138;
RX   PubMed=34253763;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K4me1.
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: STR profile from personal communication of Monteiro, Alvaro N.A.
CC   Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 10,11
ST   D18S51: 13,14
ST   D21S11: 29
ST   D3S1358: 16,17
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 11,15
ST   FGA: 20,22
ST   Penta D: 8,16
ST   Penta E: 14,18
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 14
CH   CVCL_C3MB ! IOSE11 p53R175H
CH   CVCL_YZ54 ! IOSE11CMYC
//
RX   PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739;
RA   Lawrenson, Kate
RA   Grun, Barbara
RA   Benjamin, Elizabeth
RA   Jacobs, Ian J.
RA   Dafou, Dimitra
RA   Gayther, Simon Andrew
RT   "Senescent fibroblasts promote neoplastic transformation of partially
RT   transformed ovarian epithelial cells in a three-dimensional model of
RT   early stage ovarian cancer.";
RL   Neoplasia 12:317-325(2010).
//
RX   PubMed=21859834; DOI=10.1093/carcin/bgr140;
RA   Lawrenson, Kate
RA   Sproul, Duncan
RA   Grun, Barbara
RA   Notaridou, Maria
RA   Benjamin, Elizabeth
RA   Jacobs, Ian J.
RA   Dafou, Dimitra
RA   Sims, Andrew H.
RA   Gayther, Simon Andrew
RT   "Modelling genetic and clinical heterogeneity in epithelial ovarian
RT   cancers.";
RL   Carcinogenesis 32:1540-1549(2011).
//
RX   PubMed=29844388; DOI=10.1038/s41598-018-26670-4; PMCID=PMC5974302;
RA   Gjyshi, Anxhela
RA   Dash, Sweta
RA   Cen, Ling
RA   Cheng, Chia-Ho
RA   Zhang, Chao-Mei
RA   Yoder, Sean J.
RA   Teer, Jamie K.
RA   Armaiz-Pena, Guillermo N.
RA   Monteiro, Alvaro N.A.
RT   "Early transcriptional response of human ovarian and fallopian tube
RT   surface epithelial cells to norepinephrine.";
RL   Sci. Rep. 8:8291-8291(2018).
//
RX   PubMed=25804953; DOI=10.1093/hmg/ddv101; PMCID=PMC4459387;
RA   Coetzee, Simon Gert
RA   Shen, Howard C.
RA   Hazelett, Dennis J.
RA   Lawrenson, Kate
RA   Kuchenbaecker, Karoline
RA   Tyrer, Jonathan P.
RA   Rhie, Suhn K.
RA   Levanon, Keren
RA   Karst, Alison M.
RA   Drapkin, Ronny I.
RA   Ramus, Susan J.
RA   Couch, Fergus J.
RA   Offit, Kenneth
RA   Chenevix-Trench, Georgia
RA   Monteiro, Alvaro N.A.
RA   Antoniou, Antonis
RA   Freedman, Matthew Lawrence
RA   Coetzee, Gerhard A.
RA   Pharoah, Paul D.P.
RA   Noushmehr, Houtan
RA   Gayther, Simon Andrew
RG   Consortium of Investigators of Modifiers of BRCA1/2;
RG   Ovarian Cancer Association Consortium;
RT   "Cell-type-specific enrichment of risk-associated regulatory elements
RT   at ovarian cancer susceptibility loci.";
RL   Hum. Mol. Genet. 24:3595-3607(2015).
//
RX   PubMed=25204737; DOI=10.1002/ijc.29197;
RA   Lawrenson, Kate
RA   Mhawech-Fauceglia, Paulette
RA   Worthington, Jenny
RA   Spindler, Tassja J.
RA   O'Brien, Darragh
RA   Lee, Janet M.
RA   Spain, Georgia
RA   Sharifian, Maryam
RA   Wang, Gui-Song
RA   Darcy, Kathleen M.
RA   Pejovic, Tanja
RA   Sowter, Heidi M.
RA   Timms, John F.
RA   Gayther, Simon Andrew
RT   "Identification of novel candidate biomarkers of epithelial ovarian
RT   cancer by profiling the secretomes of three-dimensional genetic models
RT   of ovarian carcinogenesis.";
RL   Int. J. Cancer 137:1806-1817(2015).
//
RX   PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979;
RA   Buckley, Melissa A.
RA   Woods, Nicholas T.
RA   Tyrer, Jonathan P.
RA   Mendoza-Fandino, Gustavo
RA   Lawrenson, Kate
RA   Hazelett, Dennis J.
RA   Najafabadi, Hamed S.
RA   Gjyshi, Anxhela
RA   Carvalho, Renato S.
RA   Lyra, Paulo C. Jr.
RA   Coetzee, Simon Gert
RA   Shen, Howard C.
RA   Yang, Ally W.
RA   Earp, Madalene A.
RA   Yoder, Sean J.
RA   Risch, Harvey
RA   Chenevix-Trench, Georgia
RA   Ramus, Susan J.
RA   Phelan, Catherine M.
RA   Coetzee, Gerhard A.
RA   Noushmehr, Houtan
RA   Hughes, Timothy R.
RA   Sellers, Thomas A.
RA   Goode, Ellen L.
RA   Pharoah, Paul D.P.
RA   Gayther, Simon Andrew
RA   Monteiro, Alvaro N.A.
RT   "Functional analysis and fine mapping of the 9p22.2 ovarian cancer
RT   susceptibility locus.";
RL   Cancer Res. 79:467-481(2019).
//
RX   PubMed=34253763; DOI=10.1038/s41598-021-93506-z; PMCID=PMC8275603;
RA   Dash, Sweta
RA   Yoder, Sean J.
RA   Mesa, Tania
RA   Smith, Andrew
RA   Cen, Ling
RA   Eschrich, Steven A.
RA   Armaiz-Pena, Guillermo N.
RA   Monteiro, Alvaro N.A.
RT   "Effects of long-term norepinephrine treatment on normal immortalized
RT   ovarian and fallopian tube cells.";
RL   Sci. Rep. 11:14334.1-14334.12(2021).
//