ID   THP-1/DC-SIGN
AC   CVCL_0R21
SY   THP-1(ATCC)/DC-SIGN; THP-1ATCC/DC-SIGN; THP-1 DC-SIGN+
DR   BEI_Resources; ARP-9943
DR   cancercelllines; CVCL_0R21
DR   Wikidata; Q54972342
RX   PubMed=14972530;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1641; CD209.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 15
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RX   PubMed=14972530; DOI=10.1016/j.virol.2003.09.028;
RA   Wu, Li
RA   Martin, Thomas D.
RA   Carrington, Mary N.
RA   KewalRamani, Vineet N.
RT   "Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated
RT   HIV transmission.";
RL   Virology 318:17-23(2004).
//