ID   B-THP-1/DC-SIGN
AC   CVCL_0R20
SY   B-THP-1 DC-SIGN+
DR   BEI_Resources; ARP-9941
DR   cancercelllines; CVCL_0R20
DR   Wikidata; Q54752142
RX   PubMed=14972530;
CC   Population: African; Nigerian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1641; CD209.
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0R19 ! B-THP-1
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 20
//
RX   PubMed=14972530; DOI=10.1016/j.virol.2003.09.028;
RA   Wu, Li
RA   Martin, Thomas D.
RA   Carrington, Mary N.
RA   KewalRamani, Vineet N.
RT   "Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated
RT   HIV transmission.";
RL   Virology 318:17-23(2004).
//