ID   RN33B
AC   CVCL_0E00
SY   Rn33B
DR   EFO; EFO_0022816
DR   ATCC; CRL-2825
DR   Wikidata; Q54950747
RX   PubMed=7905006;
RX   PubMed=8364724;
RX   PubMed=8699192;
RX   PubMed=12061867;
RX   PubMed=12112642;
RX   PubMed=15139013;
RX   PubMed=31758567;
CC   Characteristics: Profiferates at the permissive temperature (33 Celsius). At the restrictive temperature (38.5 Celsius) ceases mitotic activity and differentiates with phase bright cell bodies and 'neuritic-like' processes.
CC   Doubling time: 48 hours (PubMed=8364724).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Embryonic brain, medullary raphe nucleus; UBERON=UBERON_0002692.
CC   Breed/subspecies: Sprague Dawley; RS=RS_0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   12-13FD
CA   Conditionally immortalized cell line
DT   Created: 10-04-15; Last updated: 10-04-25; Version: 16
//
RX   PubMed=7905006; DOI=10.1016/0165-5728(94)90189-9;
RA   White L.A., Keane R.W., Whittemore S.R.;
RT   "Differentiation of an immortalized CNS neuronal cell line decreases
RT   their susceptibility to cytotoxic T cell lysis in vitro.";
RL   J. Neuroimmunol. 49:135-143(1994).
//
RX   PubMed=8364724; DOI=10.1016/0006-8993(93)91111-5;
RA   Whittemore S.R., White L.A.;
RT   "Target regulation of neuronal differentiation in a temperature-sensitive
RT   cell line derived from medullary raphe.";
RL   Brain Res. 615:27-40(1993).
//
RX   PubMed=8699192; DOI=10.1007/BF02284789;
RA   Shihabuddin L.S., Brunschwig J.-P., Holets Whittemore V.R., Bunge M.B.,
RA   Whittemore S.R.;
RT   "Induction of mature neuronal properties in immortalized neuronal
RT   precursor cells following grafting into the neonatal CNS.";
RL   J. Neurocytol. 25:101-111(1996).
//
RX   PubMed=12061867; DOI=10.1006/exnr.2002.7888;
RA   Lundberg C., Englund U., Trono D., Bjorklund A., Wictorin K.;
RT   "Differentiation of the RN33B cell line into forebrain projection
RT   neurons after transplantation into the neonatal rat brain.";
RL   Exp. Neurol. 175:370-387(2002).
//
RX   PubMed=12112642; DOI=10.1002/jgm.268;
RA   Rosenqvist N., Hard af Segerstad C., Samuelsson C., Johansen J.,
RA   Lundberg C.;
RT   "Activation of silenced transgene expression in neural precursor cell
RT   lines by inhibitors of histone deacetylation.";
RL   J. Gene Med. 4:248-257(2002).
//
RX   PubMed=15139013; DOI=10.1002/glia.20033;
RA   Wojciechowski A.B., Englund U., Lundberg C., Warfvinge K.;
RT   "Migratory capacity of the cell line RN33B and the host glial cell
RT   response after subretinal transplantation to normal adult rats.";
RL   Glia 47:58-67(2004).
//
RX   PubMed=31758567; DOI=10.1111/1348-0421.12761;
RA   Minato E., Kobayashi A., Aoshima K., Fukushi H., Kimura T.;
RT   "Susceptibility of rat immortalized neuronal cell line Rn33B
RT   expressing equine major histocompatibility class 1 to equine
RT   herpesvirus-1 infection is differentiation dependent.";
RL   Microbiol. Immunol. 64:123-132(2020).
//