ID   17CM98
AC   CVCL_0C82
DR   GEO; GSM1974774
DR   Wikidata; Q54582441
RX   PubMed=15965647;
RX   PubMed=22901430;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 22 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 42422; KIT; Simple; p.Val558_Glu560del (c.1673_1681delTTGTTGAGG); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231
ST   Dog FHC2054: 156
ST   Dog FHC2079: 271
ST   Dog PEZ1: 127
ST   Dog PEZ3: 121,131
ST   Dog PEZ5: 107
ST   Dog PEZ6: 176
ST   Dog PEZ8: 236,240
ST   Dog PEZ12: 270,274
ST   Dog PEZ20: 176
DI   NCIt; C185639; Canine oral melanoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 12
//
RX   PubMed=15965647; DOI=10.1007/s00262-005-0025-6;
RA   Alexander A.N., Huelsmeyer M.K., Mitzey A., Dubielzig R.R.,
RA   Kurzman I.D., MacEwen E.G., Vail D.M.;
RT   "Development of an allogeneic whole-cell tumor vaccine expressing
RT   xenogeneic gp100 and its implementation in a phase II clinical trial
RT   in canine patients with malignant melanoma.";
RL   Cancer Immunol. Immunother. 55:433-442(2006).
//
RX   PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001;
RA   Chon E., Thompson V., Schmid S., Stein T.J.;
RT   "Activation of the canonical Wnt/beta-catenin signalling pathway is
RT   rare in canine malignant melanoma tissue and cell lines.";
RL   J. Comp. Pathol. 148:178-187(2013).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//