ID   Hs 698.T
AC   CVCL_0855
SY   Hs-698-T; Hs698T; HS698T
DR   CLO; CLO_0004058
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-7435
DR   BioSample; SAMN03471499
DR   BioSample; SAMN10988478
DR   cancercelllines; CVCL_0855
DR   Cell_Model_Passport; SIDM01705
DR   ColonAtlas; Hs%20698.T
DR   DepMap; ACH-000850
DR   GEO; GSM887109
DR   GEO; GSM888180
DR   IARC_TP53; 30058
DR   LiGeA; CCLE_020
DR   PharmacoDB; Hs698_T_587_2019
DR   Progenetix; CVCL_0855
DR   Wikidata; Q54895900
RX   DOI=10.1101/166199;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Problematic cell line: Misclassified. Originally thought to be a colorectal carcinoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000850).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: South Asian.
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.32%; Native American=0%; East Asian, North=3.02%; East Asian, South=0%; South Asian=93.06%; European, North=0%; European, South=3.59% (PubMed=30894373).
CC   Caution: According to ATCC the ethnicity of the donor is Native American, but exome analysis finds it to be South Asian.
CC   Derived from site: In situ; Connective tissue; UBERON=UBERON_0002384.
CC   Cell type: Fibroblast; CL=CL_0000057.
ST   Source(s): ATCC=CRL-7435
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 11,12
ST   D16S539: 12
ST   D18S51: 15,18
ST   D19S433: 13,15.2
ST   D21S11: 32.2
ST   D2S1338: 20,21
ST   D3S1358: 15,16
ST   D5S818: 10,11
ST   D7S820: 8,10
ST   D8S1179: 11,13
ST   FGA: 19,23
ST   Penta D: 9,12
ST   Penta E: 16,17
ST   TH01: 8,9
ST   TPOX: 8,11
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   70Y
CA   Undefined cell line type
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
//
RX   DOI=10.1101/166199;
RA   de Weck A., Bitter H., Kauffmann A.;
RT   "Fibroblasts cell lines misclassified as cancer cell lines.";
RL   bioRxiv 2017:166199-166199(2017).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//