ID   Beta-TC-6
AC   CVCL_0605
SY   beta-TC-6; beta-TC6; beta TC6; BetaTC6; betaTC6
DR   BTO; BTO:0003428
DR   CLO; CLO_0001933
DR   ATCC; CRL-11506
DR   CCRID; 3101MOUSCSP5061
DR   CCRID; 3101MOUTCM34
DR   ChEMBL-Cells; CHEMBL3308358
DR   ChEMBL-Targets; CHEMBL614357
DR   CLS; 305181
DR   GEO; GSE70960
DR   IZSLER; BS TCL 222
DR   KCB; KCB 2010190YJ
DR   Lonza; 1688
DR   PubChem_Cell_line; CVCL_0605
DR   Wikidata; Q54796099
RX   Patent=US5773255;
RX   PubMed=7533732;
RX   PubMed=7958492;
RX   PubMed=8697299;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11506.
CC   Characteristics: Secretes insulin in response to glucose challenge. But this phenotype is unstable.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: ChIP-seq epigenome analysis.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: (C57BL/6J x DBA/2J)F2 transgenic RIP1Tag2.
DI   NCIt; C34053; Mouse insulinoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 19
//
RX   Patent=US5773255;
RA   Laurance M.E., Knaack D., Fiore D.M., Hegre O.D.;
RT   "Glucose responsive insulin secreting beta-cell lines and method for
RT   producing same.";
RL   Patent number US5773255, 30-Jun-1998.
//
RX   PubMed=7533732; DOI=10.2337/diab.44.3.306;
RA   Poitout V., Stout L.E., Armstrong M.B., Walseth T.F., Sorenson R.L.,
RA   Robertson R.P.;
RT   "Morphological and functional characterization of beta TC-6 cells --
RT   an insulin-secreting cell line derived from transgenic mice.";
RL   Diabetes 44:306-313(1995).
//
RX   PubMed=7958492; DOI=10.2337/diab.43.12.1413;
RA   Knaack D., Fiore D.M., Surana M., Leiser M., Laurance M.E.,
RA   Fusco-DeMane D., Hegre O.D., Fleischer N., Efrat S.;
RT   "Clonal insulinoma cell line that stably maintains correct glucose
RT   responsiveness.";
RL   Diabetes 43:1413-1417(1994).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//