ID   Jurkat Wurzburg
AC   CVCL_0584
SY   Wurzburg; Jurkat JR; JR
DR   MCCL; MCC:0000490
DR   cancercelllines; CVCL_0584
DR   Wikidata; Q54899145
RX   PubMed=7526398;
RX   PubMed=10468210;
CC   Population: Caucasian.
CC   Doubling time: 16.6 +- 2 hours (PubMed=10468210).
CC   Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0065 ! Jurkat
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=7526398; DOI=10.1073/pnas.91.24.11527; PMCID=PMC45264;
RA   Anderson, Michael T.
RA   Staal, Frank J.T.
RA   Gitler, Carlos
RA   Herzenberg, Leonard Arthur
RA   Herzenberg, Leonore Alderstein
RT   "Separation of oxidant-initiated and redox-regulated steps in the
RT   NF-kappa B signal transduction pathway.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11527-11531(1994).
//
RX   PubMed=10468210; DOI=10.1016/S0891-5849(99)00074-X;
RA   Schoene, Norberta W.
RA   Kamara, Kalatu S.
RT   "Population doubling time, phosphatase activity, and hydrogen peroxide
RT   generation in Jurkat cells.";
RL   Free Radic. Biol. Med. 27:364-369(1999).
//